ID   DRAXI_BOVIN             Reviewed;         337 AA.
AC   P0C8S2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Draxin {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal inhibitory axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal repulsive axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060};
DE   Flags: Precursor;
GN   Name=DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
CC   -!- FUNCTION: Chemorepulsive axon guidance protein required for the
CC       development of spinal cord and forebrain commissures. Acts as a
CC       chemorepulsive guidance protein for commissural axons during
CC       development. Able to inhibit or repel neurite outgrowth from dorsal
CC       spinal cord. Inhibits the stabilization of cytosolic beta-catenin
CC       (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist
CC       of Wnt signaling pathway. {ECO:0000255|HAMAP-Rule:MF_03060}.
CC   -!- SUBUNIT: Interacts with LRP6. {ECO:0000255|HAMAP-Rule:MF_03060}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_03060}.
CC   -!- SIMILARITY: Belongs to the draxin family. {ECO:0000255|HAMAP-
CC       Rule:MF_03060}.
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DR   EMBL; AAFC03122053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03122054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001181941.1; NM_001195012.1.
DR   AlphaFoldDB; P0C8S2; -.
DR   SMR; P0C8S2; -.
DR   STRING; 9913.ENSBTAP00000019092; -.
DR   PaxDb; P0C8S2; -.
DR   GeneID; 506110; -.
DR   KEGG; bta:506110; -.
DR   CTD; 374946; -.
DR   eggNOG; ENOG502QUE0; Eukaryota.
DR   HOGENOM; CLU_063473_0_0_1; -.
DR   InParanoid; P0C8S2; -.
DR   OrthoDB; 860902at2759; -.
DR   TreeFam; TF333255; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0007411; P:axon guidance; ISS:UniProtKB.
DR   GO; GO:0021528; P:commissural neuron differentiation in spinal cord; ISS:UniProtKB.
DR   GO; GO:0021516; P:dorsal spinal cord development; ISS:UniProtKB.
DR   GO; GO:0030900; P:forebrain development; ISS:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   HAMAP; MF_03060; Draxin; 1.
DR   InterPro; IPR029094; Draxin.
DR   PANTHER; PTHR28610; PTHR28610; 1.
DR   Pfam; PF15550; Draxin; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal;
KW   Wnt signaling pathway.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
FT   CHAIN           25..337
FT                   /note="Draxin"
FT                   /id="PRO_0000365947"
FT   REGION          36..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
SQ   SEQUENCE   337 AA;  37314 MW;  EE0C22AD55B2C27E CRC64;
     MLLLALLLLL ELSLAGSLGP GSSAQNLPEN HIDLSGPALW TPQASHHRRR GLGKKERGPG
     TPGWTQDGAV VTATRQASRL PGAEGLLHGS SPAGLLQDKG LLRGLTRPYP EKETQAPGSE
     RVKKRGREHK RRKERLRLHR GRALVRGPSS LMKKAELSED QSPDALMEES STSLAPTILY
     LTTFEAPATE ESLILPVTSL WPQAHPRPDG EVMPTLDMAL FDWTDYEDLK PEVWPSTRKK
     EKHRGKLSSD GNETSPAKGE PCDHHQDCLP GTCCDLREHL CTPHNRGLNN KCFDDCMCVE
     GLRCYAKFHR NRRVTRRKGR CVEPETANGD QGSFINV