ID   DRAXI_CHICK             Reviewed;         349 AA.
AC   B6ZI38;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Draxin {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal inhibitory axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal repulsive axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060};
DE   Flags: Precursor;
GN   Name=DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=19150847; DOI=10.1126/science.1165187;
RA   Islam S.M., Shinmyo Y., Okafuji T., Su Y., Naser I.B., Ahmed G., Zhang S.,
RA   Chen S., Ohta K., Kiyonari H., Abe T., Tanaka S., Nishinakamura R.,
RA   Terashima T., Kitamura T., Tanaka H.;
RT   "Draxin, a repulsive guidance protein for spinal cord and forebrain
RT   commissures.";
RL   Science 323:388-393(2009).
CC   -!- FUNCTION: Chemorepulsive axon guidance protein required for the
CC       development of spinal cord and forebrain commissures. Acts as a
CC       chemorepulsive guidance protein for commissural axons during
CC       development. Able to inhibit or repel neurite outgrowth from dorsal
CC       spinal cord and cortical explants in vitro. Binds directly to the
CC       neurites and growth cones. {ECO:0000255|HAMAP-Rule:MF_03060,
CC       ECO:0000269|PubMed:19150847}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_03060,
CC       ECO:0000269|PubMed:19150847}.
CC   -!- DEVELOPMENTAL STAGE: Expressed transiently during development of the
CC       brain and spinal cord, especially in the roof plate and the dorsal lip
CC       of the dermomyotome. Also present at the dorsolateral basement membrane
CC       of the spinal cord (at protein level). {ECO:0000269|PubMed:19150847}.
CC   -!- SIMILARITY: Belongs to the draxin family. {ECO:0000255|HAMAP-
CC       Rule:MF_03060}.
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DR   EMBL; AB427147; BAH02787.1; -; mRNA.
DR   RefSeq; NP_001136320.1; NM_001142848.2.
DR   RefSeq; XP_015152402.1; XM_015296916.1.
DR   AlphaFoldDB; B6ZI38; -.
DR   SMR; B6ZI38; -.
DR   STRING; 9031.ENSGALP00000007370; -.
DR   PaxDb; B6ZI38; -.
DR   Ensembl; ENSGALT00000007382; ENSGALP00000007370; ENSGALG00000004631.
DR   GeneID; 419492; -.
DR   KEGG; gga:419492; -.
DR   CTD; 374946; -.
DR   VEuPathDB; HostDB:geneid_419492; -.
DR   eggNOG; ENOG502QUE0; Eukaryota.
DR   GeneTree; ENSGT00390000013828; -.
DR   HOGENOM; CLU_063473_0_0_1; -.
DR   InParanoid; B6ZI38; -.
DR   OMA; NGEQGSF; -.
DR   OrthoDB; 860902at2759; -.
DR   PhylomeDB; B6ZI38; -.
DR   PRO; PR:B6ZI38; -.
DR   Proteomes; UP000000539; Chromosome 21.
DR   Bgee; ENSGALG00000004631; Expressed in brain and 10 other tissues.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0007411; P:axon guidance; IDA:UniProtKB.
DR   GO; GO:0021528; P:commissural neuron differentiation in spinal cord; IDA:UniProtKB.
DR   GO; GO:0021516; P:dorsal spinal cord development; IDA:UniProtKB.
DR   GO; GO:0030900; P:forebrain development; IDA:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro.
DR   HAMAP; MF_03060; Draxin; 1.
DR   InterPro; IPR029094; Draxin.
DR   PANTHER; PTHR28610; PTHR28610; 1.
DR   Pfam; PF15550; Draxin; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
FT   CHAIN           26..349
FT                   /note="Draxin"
FT                   /id="PRO_0000365948"
FT   REGION          40..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..155
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        264
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
SQ   SEQUENCE   349 AA;  39119 MW;  2337B0E10836F592 CRC64;
     MAASSTFFSP SLFLCVLVLI DITLAVSLDT DMKLKSENNN HLQNQETWPQ QPRSGHHHKH
     GLAKKGRVLA LPVRGQPAGE EALRVGSGAP AMEELVPLGQ PAALKQDKDK DVFLGFELPH
     AERENQSPGS ERGKKQNREQ RRHSRRDRLK HHRGKTAVGP SSLYKKPESF EQQFQNLQAE
     EATSPTPTVL PFTALDLVVS TEEPPVLPAT SPRSQARLRQ DGDVMPTLDM ALFDWTDYED
     LKPEMWPSAK KKEKRRSKSS NGGNETSSAE GEPCDHHLDC LPGSCCDLRE HLCKPHNRGL
     NNKCYDDCMC TEGLRCYAKF HRNRRVTRRK GRCVEPESAN GEQGSFINV