DRB3_ARATH
ID DRB3_ARATH Reviewed; 359 AA.
AC Q9LJF5; Q2V3S2;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Double-stranded RNA-binding protein 3;
DE AltName: Full=dsRNA-binding protein 3;
DE Short=AtDRB3;
GN Name=DRB3; OrderedLocusNames=At3g26932; ORFNames=MQP17.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18625233; DOI=10.1016/j.febslet.2008.07.004;
RA Curtin S.J., Watson J.M., Smith N.A., Eamens A.L., Blanchard C.L.,
RA Waterhouse P.M.;
RT "The roles of plant dsRNA-binding proteins in RNAi-like pathways.";
RL FEBS Lett. 582:2753-2760(2008).
CC -!- FUNCTION: Binds double-stranded RNA. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9LJF5; Q9ZVD5: AGO4; NbExp=2; IntAct=EBI-10815073, EBI-2352199;
CC Q9LJF5; Q9LXW7: DCL3; NbExp=2; IntAct=EBI-10815073, EBI-632737;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:18625233}.
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DR EMBL; BT012284; AAS76771.1; -; mRNA.
DR EMBL; AP000602; BAB01188.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77245.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77246.1; -; Genomic_DNA.
DR EMBL; AK222128; BAD95129.1; -; mRNA.
DR RefSeq; NP_001030779.2; NM_001035702.3.
DR RefSeq; NP_189329.3; NM_113606.5.
DR AlphaFoldDB; Q9LJF5; -.
DR SMR; Q9LJF5; -.
DR IntAct; Q9LJF5; 2.
DR MINT; Q9LJF5; -.
DR STRING; 3702.AT3G26932.1; -.
DR PaxDb; Q9LJF5; -.
DR PRIDE; Q9LJF5; -.
DR ProteomicsDB; 241259; -.
DR EnsemblPlants; AT3G26932.1; AT3G26932.1; AT3G26932.
DR EnsemblPlants; AT3G26932.2; AT3G26932.2; AT3G26932.
DR GeneID; 822310; -.
DR Gramene; AT3G26932.1; AT3G26932.1; AT3G26932.
DR Gramene; AT3G26932.2; AT3G26932.2; AT3G26932.
DR KEGG; ath:AT3G26932; -.
DR Araport; AT3G26932; -.
DR TAIR; locus:2829928; AT3G26932.
DR eggNOG; ENOG502QTBA; Eukaryota.
DR HOGENOM; CLU_038996_0_0_1; -.
DR InParanoid; Q9LJF5; -.
DR OrthoDB; 1031431at2759; -.
DR PhylomeDB; Q9LJF5; -.
DR PRO; PR:Q9LJF5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJF5; baseline and differential.
DR Genevisible; Q9LJF5; AT.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR CDD; cd19907; DSRM_AtDRB-like_rpt1; 1.
DR CDD; cd19908; DSRM_AtDRB-like_rpt2; 1.
DR InterPro; IPR044450; AtDRB-like_DSRM_1.
DR InterPro; IPR044451; AtDRB-like_DSRM_2.
DR InterPro; IPR014720; dsRBD_dom.
DR Pfam; PF00035; dsrm; 2.
DR SMART; SM00358; DSRM; 2.
DR PROSITE; PS50137; DS_RBD; 2.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..359
FT /note="Double-stranded RNA-binding protein 3"
FT /id="PRO_0000404654"
FT DOMAIN 1..70
FT /note="DRBM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT DOMAIN 87..155
FT /note="DRBM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT REGION 266..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 40074 MW; AD6DE573EF9C0605 CRC64;
MYKNQLQELA QRSCFSLPSY TCTREGPDHA PRFKASVNFN GEIFESPTYC STLRQAEHSA
AEVALSALSS KGPSKSLTAR VLDETGIYKN LLQETAHRAG LDLPVYTSVR SGPGHIPTFS
CTVELAGMSF NGESAKTKKQ AEKNAAIAAW FSLRKMPRLD PLRGEEKEQE IVARVLSRFR
PKEVKRREPN QSRRRTVIRT IRQNTTTTTT TTGDLLCEKL RSINLYTNEA SSSSPPPQRF
WPSRTNLTQE QSKVKSLLEK CQEYAEKKQS LDDPKPEMRI KTSSPSPLSS SVERNCYSKL
LPFPSFVLNH QKLAPAVHIR SVIPVCSAPP PKPNPNPNSS PFITRELGNG SQEKKSLPN
