ID   DRC10_BOVIN             Reviewed;         444 AA.
AC   Q17QH9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Dynein regulatory complex protein 10 {ECO:0000250|UniProtKB:A8J0N6};
DE   AltName: Full=IQ domain-containing protein D;
GN   Name=IQCD; Synonyms=DRC10 {ECO:0000250|UniProtKB:A8J0N6};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J0N6}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       Interacts with CFAP52 (By similarity). {ECO:0000250|UniProtKB:A8J0N6,
CC       ECO:0000250|UniProtKB:F1RKB1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:A8J0N6}.
CC   -!- SIMILARITY: Belongs to the DRC10 family. {ECO:0000305}.
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DR   EMBL; BC118347; AAI18348.1; -; mRNA.
DR   RefSeq; NP_001069074.1; NM_001075606.1.
DR   RefSeq; XP_005217869.1; XM_005217812.3.
DR   RefSeq; XP_015330951.1; XM_015475465.1.
DR   AlphaFoldDB; Q17QH9; -.
DR   SMR; Q17QH9; -.
DR   STRING; 9913.ENSBTAP00000029526; -.
DR   PaxDb; Q17QH9; -.
DR   PRIDE; Q17QH9; -.
DR   Ensembl; ENSBTAT00000029527; ENSBTAP00000029526; ENSBTAG00000001806.
DR   GeneID; 513272; -.
DR   KEGG; bta:513272; -.
DR   CTD; 115811; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001806; -.
DR   VGNC; VGNC:30252; IQCD.
DR   eggNOG; ENOG502QQS9; Eukaryota.
DR   GeneTree; ENSGT00730000111354; -.
DR   HOGENOM; CLU_637710_0_0_1; -.
DR   InParanoid; Q17QH9; -.
DR   OMA; FEDEAWF; -.
DR   OrthoDB; 1011316at2759; -.
DR   TreeFam; TF326203; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000001806; Expressed in pons and 93 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   InterPro; IPR042815; DRC10.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR31598; PTHR31598; 1.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..444
FT                   /note="Dynein regulatory complex protein 10"
FT                   /id="PRO_0000282547"
FT   DOMAIN          400..429
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          421..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          212..246
FT                   /evidence="ECO:0000255"
FT   COILED          325..397
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   444 AA;  51623 MW;  5E7B7138CC2B6123 CRC64;
     MALDVLTVAP LYQGPDINKI RLIAQTTKKS TIPPKALTPA RSKLTTIETK RIMSVLDETI
     HKVELVSLLS HAASESKTSE GMLGPDIAKA VREHEDLCQA LLDRVSYLQE EERKLQEAED
     FEDEAWFRER LFAMDLQKSQ LPPLMQEIKE STKNVVRLLL SNPQAASLLQ AQTLGRSKEA
     QCFIDSLVEL RGFLFEKLLT SPMEARDKIQ FIQDITRRNR RHQEIIDTLE NELAACVRNR
     NAEVEKENFV IQELKNHLHQ VLRFSENSLL RTKQEAEKQQ KADFRASQAR VATVQQEILV
     LQSQFYNLVM ENRDTEQALR KKKYKVETEI ENWIQKYDSE MSEKQDEYEE LDIIHKEEQL
     QLEELKKRHD VLVEEFSQIQ AEREILTKKR LEDEQEMVRM VRAATLIQAL WKGYLVRSML
     KSKKKKRGKG KGEKKGKGKG KGKK