DRC10_CHLRE
ID DRC10_CHLRE Reviewed; 356 AA.
AC A8J0N6;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Dynein regulatory complex protein 10 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
DE AltName: Full=Flagellar associated protein 84;
GN Name=DRC10 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
GN Synonyms=FAP84;
GN ORFNames=CHLRE_02g141350v5 {ECO:0000305}, CHLREDRAFT_184245;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=23427265; DOI=10.1091/mbc.e12-11-0801;
RA Bower R., Tritschler D., Vanderwaal K., Perrone C.A., Mueller J., Fox L.,
RA Sale W.S., Porter M.E.;
RT "The N-DRC forms a conserved biochemical complex that maintains outer
RT doublet alignment and limits microtubule sliding in motile axonemes.";
RL Mol. Biol. Cell 24:1134-1152(2013).
RN [3]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=25411337; DOI=10.1091/mbc.e14-09-1367;
RA Oda T., Yanagisawa H., Kikkawa M.;
RT "Detailed structural and biochemical characterization of the nexin-dynein
RT regulatory complex.";
RL Mol. Biol. Cell 26:294-304(2015).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes (PubMed:23427265, PubMed:25411337).
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC),
CC composed of at least DRC1, DRC2, DRC3, DRC4, DRC5, DRC6, DRC7, DRC8,
CC DRC9, DRC10 and DRC11 (PubMed:23427265, PubMed:25411337).
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SIMILARITY: Belongs to the DRC10 family. {ECO:0000305}.
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DR EMBL; DS496131; EDP01996.1; -; Genomic_DNA.
DR EMBL; CM008963; PNW87558.1; -; Genomic_DNA.
DR RefSeq; XP_001694844.1; XM_001694792.1.
DR AlphaFoldDB; A8J0N6; -.
DR SMR; A8J0N6; -.
DR STRING; 3055.EDP01996; -.
DR PaxDb; A8J0N6; -.
DR PRIDE; A8J0N6; -.
DR EnsemblPlants; PNW87558; PNW87558; CHLRE_02g141350v5.
DR GeneID; 5720431; -.
DR Gramene; PNW87558; PNW87558; CHLRE_02g141350v5.
DR KEGG; cre:CHLRE_02g141350v5; -.
DR HOGENOM; CLU_779290_0_0_1; -.
DR InParanoid; A8J0N6; -.
DR OMA; SEMYQER; -.
DR OrthoDB; 1570934at2759; -.
DR Proteomes; UP000006906; Chromosome 2.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR InterPro; IPR042815; DRC10.
DR PANTHER; PTHR31598; PTHR31598; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome.
FT CHAIN 1..356
FT /note="Dynein regulatory complex protein 10"
FT /id="PRO_0000444020"
FT DOMAIN 319..348
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 173..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 126..167
FT /evidence="ECO:0000255"
FT COILED 197..287
FT /evidence="ECO:0000255"
FT COMPBIAS 178..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 40926 MW; 0444028A66A5C831 CRC64;
MNSLEAGRVL SVLDEALEGI RLISYVTQDV LDTAEQLRDM LGEDLANALI KHRQLIQSAK
STLNNDQVQA STLELVRLLK KSPSAQRLQV LPYERTYGIL QTLQYFEQLR QFAQKRLTTT
VEEDSSNREF FEEVRDREER AVAEQEQLKQ KLKLQRVELQ KAAGTIQVSE DRARGEVSEV
QSSTQQSRAA IEGSARAQSE ADKSSFQSDL DQVTKELAAA RAELARLRQE HKDNEALLRK
ARKRAEQDVE VQIGEYDADV GAKEEELGKA RAEYEEVLRQ LQEYNSGWSE MYQERLEYEE
RERRLADQRF QAALLAVRQN HAARVIQSYW RGFKKAREAA KKKAKKLEKA KAAKKK
