DRC10_HUMAN
ID DRC10_HUMAN Reviewed; 449 AA.
AC Q96DY2; Q6ZSU0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Dynein regulatory complex protein 10 {ECO:0000250|UniProtKB:A8J0N6};
DE AltName: Full=IQ domain-containing protein D;
GN Name=IQCD; Synonyms=DRC10 {ECO:0000250|UniProtKB:A8J0N6};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J0N6}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC Interacts with CFAP52 (By similarity). {ECO:0000250|UniProtKB:A8J0N6,
CC ECO:0000250|UniProtKB:F1RKB1}.
CC -!- INTERACTION:
CC Q96DY2-2; Q9Y6A5: TACC3; NbExp=3; IntAct=EBI-23670573, EBI-2554984;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:A8J0N6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96DY2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96DY2-2; Sequence=VSP_024178;
CC Name=3;
CC IsoId=Q96DY2-3; Sequence=VSP_024179, VSP_024180;
CC -!- SIMILARITY: Belongs to the DRC10 family. {ECO:0000305}.
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DR EMBL; AK127152; BAC86856.1; -; mRNA.
DR EMBL; AC089999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013151; AAH13151.1; -; mRNA.
DR CCDS; CCDS81743.1; -. [Q96DY2-1]
DR CCDS; CCDS9167.1; -. [Q96DY2-2]
DR RefSeq; NP_001317381.1; NM_001330452.1. [Q96DY2-1]
DR RefSeq; NP_612460.1; NM_138451.2. [Q96DY2-2]
DR RefSeq; XP_005253890.1; XM_005253833.4. [Q96DY2-1]
DR RefSeq; XP_011536164.1; XM_011537862.2. [Q96DY2-1]
DR RefSeq; XP_011536165.1; XM_011537863.2. [Q96DY2-1]
DR AlphaFoldDB; Q96DY2; -.
DR SMR; Q96DY2; -.
DR BioGRID; 125456; 6.
DR IntAct; Q96DY2; 2.
DR iPTMnet; Q96DY2; -.
DR PhosphoSitePlus; Q96DY2; -.
DR BioMuta; IQCD; -.
DR DMDM; 143340095; -.
DR EPD; Q96DY2; -.
DR MassIVE; Q96DY2; -.
DR MaxQB; Q96DY2; -.
DR PaxDb; Q96DY2; -.
DR PeptideAtlas; Q96DY2; -.
DR PRIDE; Q96DY2; -.
DR Antibodypedia; 31238; 90 antibodies from 17 providers.
DR DNASU; 115811; -.
DR Ensembl; ENST00000299732.6; ENSP00000299732.2; ENSG00000166578.10. [Q96DY2-2]
DR Ensembl; ENST00000416617.3; ENSP00000400669.2; ENSG00000166578.10. [Q96DY2-1]
DR GeneID; 115811; -.
DR KEGG; hsa:115811; -.
DR MANE-Select; ENST00000416617.3; ENSP00000400669.2; NM_001330452.2; NP_001317381.1.
DR UCSC; uc001tuu.4; human. [Q96DY2-1]
DR CTD; 115811; -.
DR DisGeNET; 115811; -.
DR GeneCards; IQCD; -.
DR HGNC; HGNC:25168; IQCD.
DR HPA; ENSG00000166578; Group enriched (fallopian tube, testis).
DR neXtProt; NX_Q96DY2; -.
DR OpenTargets; ENSG00000166578; -.
DR PharmGKB; PA134901058; -.
DR VEuPathDB; HostDB:ENSG00000166578; -.
DR eggNOG; ENOG502QQS9; Eukaryota.
DR GeneTree; ENSGT00730000111354; -.
DR HOGENOM; CLU_637710_0_0_1; -.
DR InParanoid; Q96DY2; -.
DR OMA; FEDEAWF; -.
DR OrthoDB; 1011316at2759; -.
DR PhylomeDB; Q96DY2; -.
DR TreeFam; TF326203; -.
DR PathwayCommons; Q96DY2; -.
DR SignaLink; Q96DY2; -.
DR BioGRID-ORCS; 115811; 12 hits in 1066 CRISPR screens.
DR ChiTaRS; IQCD; human.
DR GenomeRNAi; 115811; -.
DR Pharos; Q96DY2; Tbio.
DR PRO; PR:Q96DY2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q96DY2; protein.
DR Bgee; ENSG00000166578; Expressed in left testis and 104 other tissues.
DR ExpressionAtlas; Q96DY2; baseline and differential.
DR Genevisible; Q96DY2; HS.
DR GO; GO:0036064; C:ciliary basal body; IDA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR InterPro; IPR042815; DRC10.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR31598; PTHR31598; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Flagellum; Reference proteome.
FT CHAIN 1..449
FT /note="Dynein regulatory complex protein 10"
FT /id="PRO_0000282548"
FT DOMAIN 400..429
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 422..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..125
FT /evidence="ECO:0000255"
FT VAR_SEQ 244..345
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024178"
FT VAR_SEQ 244..327
FT /note="VEKENFVIQELKNHLHQVLKFSENSLVRTKQEAEKQQKADFRASQARVAKIQ
FT QEILQLQSQFYNLVMENREAEQALRKKKYKVE -> VLFHSIAEITEEATQIFCWLGFS
FT SMIDFFFKMESRSVVQTRVQWCNLDSLQPLPPRFKRFSHHSLPSSWDYRRMPPRPANFL
FT YF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024179"
FT VAR_SEQ 328..449
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024180"
FT VARIANT 136
FT /note="L -> V (in dbSNP:rs7966313)"
FT /id="VAR_056921"
SQ SEQUENCE 449 AA; 52359 MW; 559F1BD39CB8CB11 CRC64;
MALDILAMAP LYQAPAINRI GPKTDPSKRP ADPLKPLVLS RTKLTTIEAK RIMSILDEAI
YKVELVTLLS YVASNREDME GMLGEDVMRA VREHEDLCQV LLENVRCLKE KERQLQEQKE
AEEEGWLRDR LLSIELQKSS LSPLMQQIKD STKNVLRLLL SNPQAARLLQ MQTQGRSAEA
QNFIDSLIEL RGFLFEKLLT SPMEARDKAQ FLQDISRQNS NNQQIIDTLE KELAERMKNR
NAEVEKENFV IQELKNHLHQ VLKFSENSLV RTKQEAEKQQ KADFRASQAR VAKIQQEILQ
LQSQFYNLVM ENREAEQALR KKKYKVETEI ENWIQKYDTE MGEKQEELED LDAVHREEKI
SLEELRRRHK VLVGEFAQIR EEREINSKKR MEAEQEMVRM VRAATLIQAL WKGYLVRSLL
RSKKKRGKGK AKDKEKGKQK GKEKGKGKK
