ID   DRC10_MACFA             Reviewed;         426 AA.
AC   Q4R8Y5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Dynein regulatory complex protein 10 {ECO:0000250|UniProtKB:A8J0N6};
DE   AltName: Full=IQ domain-containing protein D;
GN   Name=IQCD; Synonyms=DRC10 {ECO:0000250|UniProtKB:A8J0N6};
GN   ORFNames=QtsA-11128;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J0N6}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       Interacts with CFAP52 (By similarity). {ECO:0000250|UniProtKB:A8J0N6,
CC       ECO:0000250|UniProtKB:F1RKB1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:A8J0N6}.
CC   -!- SIMILARITY: Belongs to the DRC10 family. {ECO:0000305}.
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DR   EMBL; AB168312; BAE00436.1; -; mRNA.
DR   RefSeq; NP_001270694.1; NM_001283765.1.
DR   AlphaFoldDB; Q4R8Y5; -.
DR   SMR; Q4R8Y5; -.
DR   STRING; 9541.XP_005572378.1; -.
DR   Ensembl; ENSMFAT00000022132; ENSMFAP00000003472; ENSMFAG00000001483.
DR   GeneID; 101925980; -.
DR   CTD; 115811; -.
DR   eggNOG; ENOG502QQS9; Eukaryota.
DR   GeneTree; ENSGT00730000111354; -.
DR   Proteomes; UP000233100; Chromosome 11.
DR   Bgee; ENSMFAG00000001483; Expressed in bone marrow and 3 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   InterPro; IPR042815; DRC10.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR31598; PTHR31598; 1.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..426
FT                   /note="Dynein regulatory complex protein 10"
FT                   /id="PRO_0000282549"
FT   DOMAIN          377..406
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          18..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   426 AA;  49480 MW;  DAAE8CF1B930DFD2 CRC64;
     MALDILAMAP LYQAPAITRI GPKTDPSKRP ADPLKPLVPS RTKLTTIEAK RIMSILDEAI
     NKVELVTLLS YVASNREDVE GVLGEDIMRA VREHEEEAEE EGWLRDRLLS IELQKSSLSP
     LTQQIKDSTK NVLRLLLSNP QAARLLQMQT QSRSAEAQNF IDSLIELRGF LFEKLVTSPM
     EARDKAQFIQ DINRQNSNNQ QIIDTLENEL AERMKKRNAE VEKENFVIQE LKNHLHQVLK
     FSENSLLRTK QEAEKQQKAD FRASQARVAK IQQEILQLQS QFYNLVMENR EAEQALRKKK
     YKVETEIENW IQKYDTEMGE KQEELEDLEA VHKEEKIALE ELKRRHKVLV EEFVQIREER
     EINSKKRMEA EQEMVRMVRA ATLIQAFWKG YLVRSLLRSK KKRGKGKAKG KEKGKQKGKE
     KGKGKK