DRC10_MOUSE
ID DRC10_MOUSE Reviewed; 458 AA.
AC Q9D3V1; Q497P6; Q8C5X0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Dynein regulatory complex protein 10 {ECO:0000250|UniProtKB:A8J0N6};
DE AltName: Full=IQ domain-containing protein D;
GN Name=Iqcd; Synonyms=Drc10 {ECO:0000250|UniProtKB:A8J0N6};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J0N6}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC Interacts with CFAP52 (By similarity). {ECO:0000250|UniProtKB:A8J0N6,
CC ECO:0000250|UniProtKB:F1RKB1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:A8J0N6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D3V1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D3V1-2; Sequence=VSP_024181;
CC -!- SIMILARITY: Belongs to the DRC10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC36556.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK017032; BAB30561.1; -; mRNA.
DR EMBL; AK076996; BAC36556.1; ALT_FRAME; mRNA.
DR EMBL; BC100441; AAI00442.1; ALT_TERM; mRNA.
DR EMBL; BC125429; AAI25430.1; -; mRNA.
DR CCDS; CCDS19621.1; -. [Q9D3V1-1]
DR RefSeq; NP_083684.1; NM_029408.2. [Q9D3V1-1]
DR RefSeq; XP_011246549.1; XM_011248247.2. [Q9D3V1-1]
DR AlphaFoldDB; Q9D3V1; -.
DR SMR; Q9D3V1; -.
DR STRING; 10090.ENSMUSP00000091955; -.
DR iPTMnet; Q9D3V1; -.
DR PhosphoSitePlus; Q9D3V1; -.
DR MaxQB; Q9D3V1; -.
DR PaxDb; Q9D3V1; -.
DR PRIDE; Q9D3V1; -.
DR ProteomicsDB; 267001; -. [Q9D3V1-1]
DR ProteomicsDB; 267002; -. [Q9D3V1-2]
DR Antibodypedia; 31238; 90 antibodies from 17 providers.
DR DNASU; 75732; -.
DR Ensembl; ENSMUST00000069259; ENSMUSP00000069167; ENSMUSG00000029601. [Q9D3V1-2]
DR Ensembl; ENSMUST00000094391; ENSMUSP00000091955; ENSMUSG00000029601. [Q9D3V1-1]
DR GeneID; 75732; -.
DR KEGG; mmu:75732; -.
DR UCSC; uc008zho.1; mouse. [Q9D3V1-1]
DR UCSC; uc012ecq.1; mouse. [Q9D3V1-2]
DR CTD; 115811; -.
DR MGI; MGI:1922982; Iqcd.
DR VEuPathDB; HostDB:ENSMUSG00000029601; -.
DR eggNOG; ENOG502QQS9; Eukaryota.
DR GeneTree; ENSGT00730000111354; -.
DR HOGENOM; CLU_637710_0_0_1; -.
DR InParanoid; Q9D3V1; -.
DR OMA; FEDEAWF; -.
DR PhylomeDB; Q9D3V1; -.
DR TreeFam; TF326203; -.
DR BioGRID-ORCS; 75732; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q9D3V1; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D3V1; protein.
DR Bgee; ENSMUSG00000029601; Expressed in seminiferous tubule of testis and 68 other tissues.
DR ExpressionAtlas; Q9D3V1; baseline and differential.
DR Genevisible; Q9D3V1; MM.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR InterPro; IPR042815; DRC10.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR31598; PTHR31598; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Flagellum; Reference proteome.
FT CHAIN 1..458
FT /note="Dynein regulatory complex protein 10"
FT /id="PRO_0000282550"
FT DOMAIN 397..426
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 419..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 96..137
FT /evidence="ECO:0000255"
FT COILED 209..255
FT /evidence="ECO:0000255"
FT COILED 285..379
FT /evidence="ECO:0000255"
FT COMPBIAS 432..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 286..318
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024181"
FT CONFLICT 324
FT /note="E -> A (in Ref. 1; BAC36556)"
FT /evidence="ECO:0000305"
FT CONFLICT 339..344
FT /note="GEKQDE -> CDNQPK (in Ref. 1; BAC36556)"
FT /evidence="ECO:0000305"
FT CONFLICT 431
FT /note="D -> G (in Ref. 1; BAC36556)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 458 AA; 53351 MW; 27A5D784FC01008E CRC64;
MALDQVSIPP SYHGLAIQRI PLRTGLVPAE PMKTLVPSKS KLNTIEAKRI MSVLDEAIHK
IELITLMSYM ESHPEALEDT LPEDFVRALR EHLDIGQTLV ERASILQRRH KKLEEEEEAE
ETRNQERLLS LELHKVNLLT LAHQFRDSTK TVLRLVLGEP QFTRLLQVQA PGRSPGAQCL
LDGLVELRGF LFEKLLTSPM EVREKNQFIQ DISRRSERNQ EVIDDLQAEL ANVLKNKESE
VEKENFVIQE LKNHLHQVFK FSENSLLRTK QEAEKQQKVD FRASQVRLAK TQQDILALRA
QYHNLVMENR EAEQALRKKK YKVETEIENW IQKYDMEMGE KQDEYEDLES IHKEEKLQLE
ELRERHAVLV EEFSQIRAES EINSKKRVEA EREMVRMVRA ATLIQAVWKG YLVRSILRSK
KKKRGKGKGK DKGKGKEKPK EEKAKEKKPK AKGKGKKK
