ID   DRC10_PIG               Reviewed;         467 AA.
AC   F1RKB1;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2017, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Dynein regulatory complex protein 10;
DE   AltName: Full=IQ domain-containing protein D;
GN   Name=IQCD; Synonyms=DRC10;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc;
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH CFAP52.
RX   PubMed=33139725; DOI=10.1038/s41467-020-19113-0;
RA   Dougherty G.W., Mizuno K., Noethe-Menchen T., Ikawa Y., Boldt K.,
RA   Ta-Shma A., Aprea I., Minegishi K., Pang Y.P., Pennekamp P., Loges N.T.,
RA   Raidt J., Hjeij R., Wallmeier J., Mussaffi H., Perles Z., Elpeleg O.,
RA   Rabert F., Shiratori H., Letteboer S.J., Horn N., Young S., Struenker T.,
RA   Stumme F., Werner C., Olbrich H., Takaoka K., Ide T., Twan W.K.,
RA   Biebach L., Grosse-Onnebrink J., Klinkenbusch J.A., Praveen K.,
RA   Bracht D.C., Hoeben I.M., Junger K., Guetzlaff J., Cindric S., Aviram M.,
RA   Kaiser T., Memari Y., Dzeja P.P., Dworniczak B., Ueffing M., Roepman R.,
RA   Bartscherer K., Katsanis N., Davis E.E., Amirav I., Hamada H., Omran H.;
RT   "CFAP45 deficiency causes situs abnormalities and asthenospermia by
RT   disrupting an axonemal adenine nucleotide homeostasis module.";
RL   Nat. Commun. 11:5520-5520(2020).
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J0N6}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC) (By
CC       similarity). Interacts with CFAP52 (PubMed:33139725).
CC       {ECO:0000250|UniProtKB:A8J0N6, ECO:0000269|PubMed:33139725}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:A8J0N6}.
CC   -!- SIMILARITY: Belongs to the DRC10 family. {ECO:0000305}.
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DR   EMBL; AEMK02000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000010543; -.
DR   PaxDb; F1RKB1; -.
DR   PRIDE; F1RKB1; -.
DR   Ensembl; ENSSSCT00000047702; ENSSSCP00000040204; ENSSSCG00000009877.
DR   VGNC; VGNC:89187; IQCD.
DR   eggNOG; ENOG502QQS9; Eukaryota.
DR   GeneTree; ENSGT00730000111354; -.
DR   HOGENOM; CLU_637710_0_0_1; -.
DR   InParanoid; F1RKB1; -.
DR   OMA; FEDEAWF; -.
DR   OrthoDB; 1011316at2759; -.
DR   TreeFam; TF326203; -.
DR   Proteomes; UP000008227; Chromosome 14.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000009877; Expressed in testis and 40 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   InterPro; IPR042815; DRC10.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR31598; PTHR31598; 1.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..467
FT                   /note="Dynein regulatory complex protein 10"
FT                   /id="PRO_0000454208"
FT   DOMAIN          400..429
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          422..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          334..382
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        435..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   467 AA;  54393 MW;  DF22AF25D65614AE CRC64;
     MALDILAVAP LYQGPDINKI RLMAETTKKS TTPPKPLTPS RTKLTTIETK RIMSVLDETI
     HKVELVTLLS NVASSSQSLE GMLGEDIMKA VREHVDLCQT LLDHVNYLQE EEQRLQEEEG
     FEDEPWFRDL VFSIELQKSR LPPLRQQIRE STKNVLRLLL RNPQAASLLQ VQSLGRSEEA
     QSFIDSLVEL RGFLFEKLLT SPMEARDKTQ FIQDITRRNR RNQEIIDTLE NELAACMRNR
     DAEVEKENFV VQELKNHLHQ VLKFSENSLL RTKQEAEKQQ KADFRASQAR VAKIQQEILL
     LRSQFHNLVM ENREAEQALR KKKYKVETEI ENWIQKYDLE MSEKQDEYEE LDIIHKEEKL
     QLEELKQRHS VLVEEFSQIQ AEREIKAKER LEAEQEMVRM VRAATLIQAL WKGYLVRSML
     RSKKKKRNKG KVKDKEKGKG KEKGKGKGKE KGKGKEKGKG KKGKGKK