DRC10_RAT
ID DRC10_RAT Reviewed; 457 AA.
AC Q5XIR6;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Dynein regulatory complex protein 10 {ECO:0000250|UniProtKB:A8J0N6};
DE AltName: Full=IQ domain-containing protein D;
GN Name=Iqcd; Synonyms=Drc10 {ECO:0000250|UniProtKB:A8J0N6};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J0N6}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC Interacts with CFAP52 (By similarity). {ECO:0000250|UniProtKB:A8J0N6,
CC ECO:0000250|UniProtKB:F1RKB1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:A8J0N6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5XIR6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5XIR6-2; Sequence=VSP_024182, VSP_024183;
CC -!- SIMILARITY: Belongs to the DRC10 family. {ECO:0000305}.
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DR EMBL; AABR03082200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC083607; AAH83607.1; -; mRNA.
DR AlphaFoldDB; Q5XIR6; -.
DR SMR; Q5XIR6; -.
DR STRING; 10116.ENSRNOP00000001860; -.
DR PaxDb; Q5XIR6; -.
DR PRIDE; Q5XIR6; -.
DR Ensembl; ENSRNOT00000112938; ENSRNOP00000079683; ENSRNOG00000001377. [Q5XIR6-2]
DR RGD; 1560757; Iqcd.
DR VEuPathDB; HostDB:ENSRNOG00000001377; -.
DR eggNOG; ENOG502QQS9; Eukaryota.
DR GeneTree; ENSGT00550000075100; -.
DR HOGENOM; CLU_637710_0_0_1; -.
DR InParanoid; Q5XIR6; -.
DR OMA; FEDEAWF; -.
DR PhylomeDB; Q5XIR6; -.
DR TreeFam; TF326203; -.
DR PRO; PR:Q5XIR6; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000001378; Expressed in testis and 6 other tissues.
DR GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR InterPro; IPR042815; DRC10.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR31598; PTHR31598; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Flagellum; Reference proteome.
FT CHAIN 1..457
FT /note="Dynein regulatory complex protein 10"
FT /id="PRO_0000282551"
FT DOMAIN 397..426
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 419..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 101..127
FT /evidence="ECO:0000255"
FT COILED 209..258
FT /evidence="ECO:0000255"
FT COILED 292..381
FT /evidence="ECO:0000255"
FT COMPBIAS 432..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 319..334
FT /note="KKYKVETEIENWIQKY -> VLSSISSNHMVAHSHP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024182"
FT VAR_SEQ 335..457
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024183"
SQ SEQUENCE 457 AA; 53256 MW; A13996C4EE95FEAB CRC64;
MALNLLSIPP SYHGLIIQRI PLKTGLVPAE PLKTLAPSKS KLNTIEAKRI MSVLDEAINK
VELITLMSYL ESHPEALEDA LPENFVEAIR EHLDIGQALV EKASILQRKQ KELEKGEEAE
EDWDQERLLS IELHKTNLWP LTHQFRDSTK TILRLLINEP QLTRLLHTQA PGRSPGAQCL
LTSLVELRGF LFEKLLTSPM EVREKNQFIQ DISRRSKRNQ EIIDALQAEL AEVLKNKEAE
VEKENFVIQE LKNHLHQVFK FSENSLLRTK QEAEKQQKVD YRASQARQAK TQQDILALRA
QYHNLVMENR EAEQALRKKK YKVETEIENW IQKYDMEMNE KQEEYEDLET IHKEEKLQLE
ELKERHAVLV EEFSQIRAES EINSKKRVEA EREMVRMVRA ATLIQAMWKG YLVRSMLRSR
KKKRVKSKGK DKGKGKEKPK EEKGKEKKAK GKGKGKK
