DRC11_CHLRE
ID DRC11_CHLRE Reviewed; 555 AA.
AC A8IHT2;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Dynein regulatory complex protein 11 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
DE AltName: Full=Flagellar-associated protein 82;
GN Name=DRC11 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
GN Synonyms=FAP82; ORFNames=CHLREDRAFT_169559;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH DRC5, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=23427265; DOI=10.1091/mbc.e12-11-0801;
RA Bower R., Tritschler D., Vanderwaal K., Perrone C.A., Mueller J., Fox L.,
RA Sale W.S., Porter M.E.;
RT "The N-DRC forms a conserved biochemical complex that maintains outer
RT doublet alignment and limits microtubule sliding in motile axonemes.";
RL Mol. Biol. Cell 24:1134-1152(2013).
RN [3]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=25411337; DOI=10.1091/mbc.e14-09-1367;
RA Oda T., Yanagisawa H., Kikkawa M.;
RT "Detailed structural and biochemical characterization of the nexin-dynein
RT regulatory complex.";
RL Mol. Biol. Cell 26:294-304(2015).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes (PubMed:25411337, PubMed:23427265).
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC),
CC composed of at least DRC1, DRC2, DRC3, DRC4, DRC5, DRC6, DRC7, DRC8,
CC DRC9, DRC10 and DRC11 (PubMed:25411337, PubMed:23427265). Interacts
CC with DRC5 (PubMed:23427265). {ECO:0000269|PubMed:23427265,
CC ECO:0000269|PubMed:25411337}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. DRC11 subfamily.
CC {ECO:0000305}.
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DR EMBL; DS496117; EDP05924.1; -; Genomic_DNA.
DR RefSeq; XP_001690665.1; XM_001690613.1.
DR AlphaFoldDB; A8IHT2; -.
DR SMR; A8IHT2; -.
DR STRING; 3055.EDP05924; -.
DR PaxDb; A8IHT2; -.
DR PRIDE; A8IHT2; -.
DR EnsemblPlants; PNW80688; PNW80688; CHLRE_07g325762v5.
DR GeneID; 5716259; -.
DR Gramene; PNW80688; PNW80688; CHLRE_07g325762v5.
DR eggNOG; KOG0740; Eukaryota.
DR HOGENOM; CLU_005923_0_0_1; -.
DR InParanoid; A8IHT2; -.
DR OrthoDB; 127946at2759; -.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 2.
DR PROSITE; PS50096; IQ; 2.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum.
FT CHAIN 1..555
FT /note="Dynein regulatory complex protein 11"
FT /id="PRO_0000444021"
FT DOMAIN 154..183
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 199..226
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 232..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 62729 MW; 7E0917ADC8C53695 CRC64;
MWREAMMELL DQLEAENPED PALAPKDLSE WACIYIKYLQ IMRKLETAYD QMVHPQKRQD
MRKALEACIG RMLEIRHWMV KLNRGLDFIN LDDILVDLKL GPEVLEVPVP KYFIEDRAKE
LDDRDKFLEA LIEKYNVKGP AASPIIRIGA PLGEDEAILM IQKNERGRQA RERARLAAIT
KRQRQIEDRR VRLGVTLSHE EAARKIQAAI RGFLWRRRIK KEADKELMFI GMKPKPRDPK
RDPQMGEAKN LMRRKRVQLE HGREYDEAIV NLKGKVRELE GQDMRETIQD KVNAWFVEKR
NPDTGEYPDF PDPDDGGSRA ILNPPPPSLA SLLEDAAGDG KGKGKDGKGD AKKDAKKDPK
KDKKGGGDEP QAEEQKIGAV FIPAIEAAVQ EFVAKWQDRD EADNFHQKYD AELVKDELRP
IVFEEIRLQV DGEMRVLLQN LKDLVEAERA AKLGKKGKKK KGKKKEPFSR IKKELLKEAK
TLAPGERVLV LGNSREPYLC AKKDEKDAAG DGKGKGKDGK GGGKPGTAGS KPGTADKKKK
GGKKKSLCSD WSCGA
