DRC11_MOUSE
ID DRC11_MOUSE Reviewed; 857 AA.
AC Q9CUL5; Q3UT65; Q9D4P1;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Dynein regulatory complex protein 11 {ECO:0000250|UniProtKB:A8IHT2};
DE AltName: Full=IQ and AAA domain-containing protein 1;
GN Name=Iqca1; Synonyms=Drc11 {ECO:0000250|UniProtKB:A8IHT2}, Iqca;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-353 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Egg, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. {ECO:0000250|UniProtKB:A8IHT2}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC {ECO:0000250|UniProtKB:A8IHT2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:A8IHT2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9CUL5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CUL5-2; Sequence=VSP_024334, VSP_024335;
CC Name=3;
CC IsoId=Q9CUL5-3; Sequence=VSP_024333, VSP_024336, VSP_024337;
CC -!- SIMILARITY: Belongs to the AAA ATPase family. DRC11 subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK015512; BAB29877.1; -; mRNA.
DR EMBL; AK016353; BAB30202.1; -; mRNA.
DR EMBL; AK139726; BAE24115.1; -; mRNA.
DR EMBL; AC110261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC124227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q9CUL5; -.
DR SMR; Q9CUL5; -.
DR BioGRID; 217079; 3.
DR STRING; 10090.ENSMUSP00000108717; -.
DR iPTMnet; Q9CUL5; -.
DR PhosphoSitePlus; Q9CUL5; -.
DR jPOST; Q9CUL5; -.
DR MaxQB; Q9CUL5; -.
DR PRIDE; Q9CUL5; -.
DR Antibodypedia; 34467; 87 antibodies from 15 providers.
DR Ensembl; ENSMUST00000212394; ENSMUSP00000148643; ENSMUSG00000026301. [Q9CUL5-1]
DR UCSC; uc007bzf.2; mouse. [Q9CUL5-3]
DR MGI; MGI:1922168; Iqca.
DR VEuPathDB; HostDB:ENSMUSG00000026301; -.
DR eggNOG; ENOG502QTPP; Eukaryota.
DR GeneTree; ENSGT00940000154067; -.
DR InParanoid; Q9CUL5; -.
DR PhylomeDB; Q9CUL5; -.
DR ChiTaRS; Iqca; mouse.
DR PRO; PR:Q9CUL5; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CUL5; protein.
DR Bgee; ENSMUSG00000026301; Expressed in animal zygote and 61 other tissues.
DR ExpressionAtlas; Q9CUL5; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Cell projection; Cilium; Cytoplasm;
KW Cytoskeleton; Flagellum; Nucleotide-binding; Reference proteome.
FT CHAIN 1..857
FT /note="Dynein regulatory complex protein 11"
FT /id="PRO_0000283573"
FT DOMAIN 206..235
FT /note="IQ"
FT REGION 348..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..373
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 598..605
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..394
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_024333"
FT VAR_SEQ 309..313
FT /note="NLTGT -> LGCCS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024334"
FT VAR_SEQ 314..857
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024335"
FT VAR_SEQ 480..516
FT /note="EQTIVFPREVFGNPRVALVSLHIRALWGISYLSFNNG -> KNKGRKGRRGK
FT RGKKEKDLTADR (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_024336"
FT VAR_SEQ 735..739
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_024337"
FT CONFLICT 189
FT /note="Q -> K (in Ref. 1; BAB30202)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="K -> R (in Ref. 1; BAB29877)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 857 AA; 99875 MW; 6DC624B6E5DBE875 CRC64;
MSNLMYNKMW HQTQEALNSL LDKEFQKMSE PQANKVLVFQ MLATFYINYV QIFRNMENVY
DQIVHPQKRM LIRKVLDGVM GRILELKNEM VELEMTEFHY FDDILQDLKL SPQQLDVPIP
RYFLKERLEV IKGREKILAR ILTECGLNLP VKYAAKSIAL EEAVKLIQIA ERARQGRLRA
LFMKQIFLQE CRAKEMKLLG HRLLDTKLAA LQIQKVWRGF HQCKKTVKER EEEMVFLGMK
PSPLFNEVSD AIVQSKQVTN LRDEVQLKHE QDYQEALVNI KEDLKMLEGP DIKEHLQDQI
RQWFIECRNL TGTFPDYPNE EDGGSALIFS NKTPEQVMGD IIATQEEEEK LKKKKKKEDK
ENKGKKGKKE KKEKKEKKVS LKEKAMKDED EEWKMSPSLF LQLMEEGNSL YKDIWLNKDE
SWNFPQDYDP ELIKEEKRKE LEMEIRVQVD ELMRQELKNL KLAVNREMEI PPRQKKGKKE
QTIVFPREVF GNPRVALVSL HIRALWGISY LSFNNGTIES LYQELVEKGL LIQALKVNLS
DYIGEYSYLG TTLRQVAIEP MPSLLDVRQL ITLYGILPLG SAEVHERAPL VKSLLLAGPS
GVGKKMLVHA ICTETGANLF NLSALNIAGK YPGKTGLQMM IHLVFKVARQ LQPSVVWIQD
TEKTFYKKVP QAEKRFEPKR LKRYLPKLLK LLKPDDRILI VGTTHRPFDA ELQPFCRVYQ
KIILVPRPDY ASRYGKFHEV LWKEIILRNG GKLTNSLNIS CLSKVTDGFT QGQIVQVIKD
VLTERRLRQQ AHKPLTAIEF ITMMTNMNPV YREEEESFKN WYAKTPLGKK RVLSLTVGNK
EKEKDKGKKG KRGKKKK
