DRC1_BOVIN
ID DRC1_BOVIN Reviewed; 712 AA.
AC Q32KY1; Q0V7L5;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Dynein regulatory complex protein 1;
DE AltName: Full=Coiled-coil domain-containing protein 164;
GN Name=DRC1; Synonyms=CCDC164;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. Plays a critical role in the assembly of N-
CC DRC and also stabilizes the assembly of multiple inner dynein arms and
CC radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold
CC needed for assembly of the N-DRC and its attachment to the outer
CC doublet microtubules. {ECO:0000250|UniProtKB:P0DL09,
CC ECO:0000250|UniProtKB:Q96MC2}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC {ECO:0000250|UniProtKB:P0DL09}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:P0DL09}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q32KY1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q32KY1-2; Sequence=VSP_023121;
CC -!- SIMILARITY: Belongs to the DRC1 family. {ECO:0000305}.
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DR EMBL; BT026555; ABH06342.1; -; mRNA.
DR EMBL; BC109861; AAI09862.1; -; mRNA.
DR RefSeq; NP_001032680.1; NM_001037591.1. [Q32KY1-1]
DR AlphaFoldDB; Q32KY1; -.
DR SMR; Q32KY1; -.
DR STRING; 9913.ENSBTAP00000012714; -.
DR PaxDb; Q32KY1; -.
DR PRIDE; Q32KY1; -.
DR Ensembl; ENSBTAT00000012714; ENSBTAP00000012714; ENSBTAG00000009649. [Q32KY1-1]
DR Ensembl; ENSBTAT00000044033; ENSBTAP00000041552; ENSBTAG00000009649. [Q32KY1-2]
DR GeneID; 509524; -.
DR KEGG; bta:509524; -.
DR CTD; 92749; -.
DR VEuPathDB; HostDB:ENSBTAG00000009649; -.
DR eggNOG; ENOG502QQ2B; Eukaryota.
DR GeneTree; ENSGT00940000153804; -.
DR HOGENOM; CLU_012489_1_0_1; -.
DR InParanoid; Q32KY1; -.
DR OMA; LEKSECY; -.
DR OrthoDB; 258073at2759; -.
DR TreeFam; TF324985; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000009649; Expressed in oviduct epithelium and 74 other tissues.
DR ExpressionAtlas; Q32KY1; baseline.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IMP:UniProtKB.
DR GO; GO:0060285; P:cilium-dependent cell motility; IMP:UniProtKB.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0003352; P:regulation of cilium movement; IBA:GO_Central.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR PANTHER; PTHR21625; PTHR21625; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Flagellum; Reference proteome.
FT CHAIN 1..712
FT /note="Dynein regulatory complex protein 1"
FT /id="PRO_0000277880"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..388
FT /evidence="ECO:0000255"
FT COILED 663..698
FT /evidence="ECO:0000255"
FT COMPBIAS 563..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 227..296
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_023121"
FT CONFLICT 344
FT /note="L -> P (in Ref. 1; ABH06342)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 712 AA; 84070 MW; B508E33F1CD311E3 CRC64;
MNPPGSLGVL EEKEEEHLAP PILGPSIHSD NPQERIQARR LRIAARLEAR RREALGEYLD
GKKESEEDQS KSYKQKEESR LKLAKLLLCG TELVTNIQVA ADIREIHRRV EEEEIKRQRL
EKLENEVKTS QDKFDEITVK WEEGKQRRIP QELWEMLNAQ QVHCAGLIED KNKLISELQQ
ELKMKDDQYV KDLKKQSDDI CLLLERMEEQ VKNVMKTFRQ ELQNIEKAFE VERQELLTSN
KKKWERALQA HNAKELEYLM NRIKKVEDYE KQLNKQRIWD CEEYNTIKIK LEQDVQILEQ
QLQQMKATYQ LNQEKLEYNF QVLKKRDEES TVIKSQQKRK INRLHDVLNN LRSKYNKQVK
QFQEENQSLT SDYKRLVLQF KELQKAMRHF ALIDDKRFRE IWLMNEEEAK DLINRAFDVD
RIISTHHLGL PWMAPDFWFL KNVGPISQQQ QKSATQILEE VLMEAEKEGA DEDSSESETY
LDLPKQVSAR TTRKILMLLC DESGFLIESK LLSLLLPLEK NECYLLRLDA VFSALGIENE
DDLYKLVNFF LKYQTHHSPS SQEPLDLRAE KERSLVDGKS QEKEPPPSPK LIHPNDVLKI
LEAFVMSLRK PRDFWVPVKL LKAVRDDSKD SEYWEALTTV IPATTLNLWD ALYTALEKYH
LVLTQRAELL IENSSLERQN TELQQLLQQY LDTKINSELQ VPPTQVFRVP TK
