DRC1_DANRE
ID DRC1_DANRE Reviewed; 670 AA.
AC F1QRC1; B1WB57;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Dynein regulatory complex protein 1;
DE AltName: Full=Coiled-coil domain-containing protein 164;
GN Name=drc1; Synonyms=ccdc164; ORFNames=si:dkey-65b13.6;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. Plays a critical role in the assembly of N-
CC DRC and also stabilizes the assembly of multiple inner dynein arms and
CC radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold
CC needed for assembly of the N-DRC and its attachment to the outer
CC doublet microtubules. {ECO:0000250|UniProtKB:P0DL09,
CC ECO:0000250|UniProtKB:Q96MC2}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC {ECO:0000250|UniProtKB:P0DL09}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:P0DL09}.
CC -!- SIMILARITY: Belongs to the DRC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI21200.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL929220; CAI21200.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC161624; AAI61624.1; -; mRNA.
DR RefSeq; NP_001120940.1; NM_001127468.1.
DR AlphaFoldDB; F1QRC1; -.
DR SMR; F1QRC1; -.
DR STRING; 7955.ENSDARP00000061828; -.
DR PaxDb; F1QRC1; -.
DR PRIDE; F1QRC1; -.
DR Ensembl; ENSDART00000061829; ENSDARP00000061828; ENSDARG00000042182.
DR GeneID; 100034551; -.
DR KEGG; dre:100034551; -.
DR CTD; 92749; -.
DR ZFIN; ZDB-GENE-041001-218; drc1.
DR eggNOG; ENOG502QQ2B; Eukaryota.
DR GeneTree; ENSGT00940000153804; -.
DR HOGENOM; CLU_012489_0_0_1; -.
DR InParanoid; F1QRC1; -.
DR OMA; LEKSECY; -.
DR OrthoDB; 258073at2759; -.
DR PhylomeDB; F1QRC1; -.
DR TreeFam; TF324985; -.
DR PRO; PR:F1QRC1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000042182; Expressed in testis and 27 other tissues.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR GO; GO:0003352; P:regulation of cilium movement; IBA:GO_Central.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR PANTHER; PTHR21625; PTHR21625; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome.
FT CHAIN 1..670
FT /note="Dynein regulatory complex protein 1"
FT /id="PRO_0000421991"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 55..261
FT /evidence="ECO:0000255"
FT COILED 326..382
FT /evidence="ECO:0000255"
FT COMPBIAS 7..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 45
FT /note="K -> R (in Ref. 2; AAI61624)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="M -> I (in Ref. 2; AAI61624)"
FT /evidence="ECO:0000305"
FT CONFLICT 460
FT /note="E -> G (in Ref. 2; AAI61624)"
FT /evidence="ECO:0000305"
FT CONFLICT 586
FT /note="H -> Q (in Ref. 2; AAI61624)"
FT /evidence="ECO:0000305"
FT CONFLICT 606
FT /note="A -> V (in Ref. 2; AAI61624)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 670 AA; 78176 MW; FDE7E2DF4F810A18 CRC64;
MHQTEAFAAG EEAEELRPSV ESDKKEERIL ARRLRLAARK EAQTKQRLGE DDLGKEDVKE
ETRKSQKEVE HRERRMAKLK SDGLELVTNI QVAADARESD RRTELEEGHR LRREKLENEA
KSSQEKFEEI NRKWTDAKMK QTPLDLRDAL SSQQQLCEQI IADKNKLISE LQQELKASDD
RYVKDLKRQA KDIDLLVERM EEQISTLKKS YREDLHQIEN SLDEERRTLL TKHKKKWEHE
RKDRNEKELK NMMQSLSVME EYADLLQKLR VQTAEEYNID KIRMDTEVQK LRMKVQQTKF
NCHMNEEKLD YKYEVLKKKE EENAIIKSQL KRKIIRMQDV LNNLKSKLTK QEKQSKAGNQ
SLSNDYTRIS QQYKDMQKKA RHFAALDAER LEKLWLMCED EAKALTHRAL ETDRVIHEQQ
LGLEWASPPL PFMERSGAVQ QKTFRTATQA AADTLKGEPE GGLDEDTAAG LNKRTVKSIL
ELLCDEMGFL VESKLLMLLS PLEKNEQSLI KLDAIFSAIG IESEKDVYKM AEFFMNYRQH
ESKYTKDETA NGQGESAEEL SNLIHTEDLL AALKDFTAQF CRQDVHASHK SSILGLDMRD
DSEDAAYWES IANVMPESKL KLWDALDTAL NKYHAVLTER TELLMETQNI QQQNSELRQL
LHLYTTSKAQ
