DRC1_DROME
ID DRC1_DROME Reviewed; 743 AA.
AC Q9W3J8;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Dynein regulatory complex protein 1 homolog;
GN ORFNames=CG10958;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the DRC1 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF46328.1; -; Genomic_DNA.
DR EMBL; AY051637; AAK93061.1; -; mRNA.
DR RefSeq; NP_572445.1; NM_132217.4.
DR AlphaFoldDB; Q9W3J8; -.
DR SMR; Q9W3J8; -.
DR BioGRID; 58204; 1.
DR IntAct; Q9W3J8; 7.
DR STRING; 7227.FBpp0071104; -.
DR PaxDb; Q9W3J8; -.
DR PRIDE; Q9W3J8; -.
DR DNASU; 31736; -.
DR EnsemblMetazoa; FBtr0071153; FBpp0071104; FBgn0030004.
DR GeneID; 31736; -.
DR KEGG; dme:Dmel_CG10958; -.
DR UCSC; CG10958-RA; d. melanogaster.
DR FlyBase; FBgn0030004; CG10958.
DR VEuPathDB; VectorBase:FBgn0030004; -.
DR eggNOG; ENOG502QQ2B; Eukaryota.
DR GeneTree; ENSGT00940000153804; -.
DR HOGENOM; CLU_012489_0_1_1; -.
DR InParanoid; Q9W3J8; -.
DR OMA; LEKSECY; -.
DR OrthoDB; 258073at2759; -.
DR PhylomeDB; Q9W3J8; -.
DR BioGRID-ORCS; 31736; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31736; -.
DR PRO; PR:Q9W3J8; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030004; Expressed in testis and 23 other tissues.
DR Genevisible; Q9W3J8; DM.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IBA:GO_Central.
DR GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR GO; GO:0003352; P:regulation of cilium movement; IBA:GO_Central.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR PANTHER; PTHR21625; PTHR21625; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..743
FT /note="Dynein regulatory complex protein 1 homolog"
FT /id="PRO_0000277886"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..332
FT /evidence="ECO:0000255"
FT COILED 395..416
FT /evidence="ECO:0000255"
FT COILED 715..742
FT /evidence="ECO:0000255"
FT COMPBIAS 1..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 88162 MW; 815DF77DD9202A73 CRC64;
MDDNEDELEE HQELVSDGSV EEEEEVEPDL GPVDSWESFN DRIDGLIFNE RCDKSVKKLD
ERRLAILNRV RQQFREAPKG VAERCQAQKS PIDQRLELSS ERLNELVRFG KELVTNVRVA
NERRELNRRL FEGAQKNQMH VKLQRESVET MARFENIKAR WTELEETNEP MLLWDQIEEQ
KKRIAEIMAR KDEMISACQA EVDRMNAKYE FDRERQAQDL CCLVERVDHQ VETLKEAYKE
HIQMLRQTIE EERQIFADNA VEKWRTFFDA MNANFDEKAN LVRAREQFYA RQTQQINESQ
EELTKSTRIR LEKECERLEL ELRRTRDNVL MNSEKLDYNY QVLQKRNEEN VIINNQQKRR
VARLHEAIGR TRRGLKNLYN TGKRNIARLS SDIYKLHSNI NDMESKAHQA RLNNREKFDR
IWEINYKELN LLVDRVYHID RIIHEQQLAM PWSSPVPPIP NINKAKKKRN NILEKFDMRI
GRVPKNRVMP NSGVNCKPDI KELPPDSLRL MRNLIRKLSD RGGFLIEERL LKILEPYSEE
EKCLVRIDNI FAALRIRHLR DVKELTKVFM PYTYCPNCQP QGLSPRKCAE VFMKDQKPNR
LQGAAGGQPD EKEHRSTGDT FLPKSEVAAK RCHNHYLVME PALCLHAMNL FTSKMHKKMY
EHEPGSILNA VNLIQITDAE IRNFWRQFSA CFPASKCKLW KTLEHGLNHY VEVLKMRVQY
DAEVVFLRRQ NEELRHLLQK FTV
