DRC1_MACFA
ID DRC1_MACFA Reviewed; 740 AA.
AC Q95JM8; G7PLT7; Q95JJ7; Q95JM0; Q95JQ2; Q95K05; Q9N029;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 2.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Dynein regulatory complex protein 1;
DE AltName: Full=Coiled-coil domain-containing protein 164;
GN Name=DRC1; Synonyms=CCDC164;
GN ORFNames=QccE-11935, QtsA-11540, QtsA-14589, QtsA-15139, QtsA-15601,
GN QtsA-16686;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-740 (ISOFORM 1).
RC TISSUE=Brain cortex;
RX PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT chromosomes.";
RL Gene 275:31-37(2001).
RN [4]
RP ERRATUM OF PUBMED:11574149.
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL Gene 278:267-267(2001).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. Plays a critical role in the assembly of N-
CC DRC and also stabilizes the assembly of multiple inner dynein arms and
CC radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold
CC needed for assembly of the N-DRC and its attachment to the outer
CC doublet microtubules. {ECO:0000250|UniProtKB:P0DL09,
CC ECO:0000250|UniProtKB:Q96MC2}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC {ECO:0000250|UniProtKB:P0DL09}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:P0DL09}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q95JM8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q95JM8-2; Sequence=VSP_023122, VSP_023123;
CC -!- SIMILARITY: Belongs to the DRC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB01685.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB63073.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=EHH55432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB070022; BAB62967.1; -; mRNA.
DR EMBL; AB070128; BAB63073.1; ALT_SEQ; mRNA.
DR EMBL; AB070153; BAB63098.1; -; mRNA.
DR EMBL; AB070161; BAB63106.1; -; mRNA.
DR EMBL; AB070184; BAB63129.1; -; mRNA.
DR EMBL; CM001288; EHH55432.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB046103; BAB01685.1; ALT_FRAME; mRNA.
DR AlphaFoldDB; Q95JM8; -.
DR SMR; Q95JM8; -.
DR STRING; 9541.XP_005576748.1; -.
DR eggNOG; ENOG502QQ2B; Eukaryota.
DR Proteomes; UP000009130; Chromosome 13.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR PANTHER; PTHR21625; PTHR21625; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Flagellum; Reference proteome.
FT CHAIN 1..740
FT /note="Dynein regulatory complex protein 1"
FT /id="PRO_0000277882"
FT REGION 56..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 101..387
FT /evidence="ECO:0000255"
FT COILED 691..724
FT /evidence="ECO:0000255"
FT VAR_SEQ 700..706
FT /note="ENSSLEQ -> ELQRPMC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_023122"
FT VAR_SEQ 707..740
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_023123"
FT CONFLICT 49
FT /note="P -> A (in Ref. 1; BAB63129/BAB62967/BAB63098/
FT BAB63106/BAB63073)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="Y -> C (in Ref. 1; BAB63129)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="F -> S (in Ref. 3; BAB01685)"
FT /evidence="ECO:0000305"
FT CONFLICT 487
FT /note="V -> I (in Ref. 1; BAB63129/BAB62967/BAB63098/
FT BAB63106)"
FT /evidence="ECO:0000305"
FT CONFLICT 698
FT /note="L -> P (in Ref. 1; BAB63106)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="R -> W (in Ref. 1; BAB63129/BAB63098/BAB63106)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 740 AA; 87010 MW; BD469870D2E96349 CRC64;
MNPPGSLAGL DPNLDEHLST QILAPSVHSD NPQERIQARR LRIAARLEPR RREALGEYLD
GKKESEEDQS KSYKQKEESR LKLAKLLLCG TELVTNIQVA IDIREIHRRV EEEEIKRQRI
EKLENEVKTS QDKFDEITSK WEEGKQKRIP QELWEMLNTQ QLHCAGLLED KNKLISELQQ
ELKTKDDQYV KDLKKQSDDI CLLLERMEEQ VKNVMKTFRE ELYNIEKAFE VERQELLASN
KKKWERALQA HNAKELEYLT NRMKKVEDYE KQLNRQRIWD CEEYNTIKIK LEQDVQILEQ
QLQQRKAIYQ LNQEKLEYNL QVLKKRDEES TVIKSQQKRK INRLHDILNN LRSKYAKQIK
QFQEENQSLT LDYKRLVLQF KELQKAMRHF ALIDDEKFRE IWLMNEEEAK DLIARAFDVD
RIIHTHHLGL PWTAPDFWFL KNVGPISQQP QKSATQIVEE MLMHTEEEEA EEAASEPESY
LDLPKQVSEK TTKKILMLLC DESGFLIESK LLSLLLPLEQ NECYLLRLDA IFSALGIESE
DDLYKLVNFF LKYRAHRLSS SLQIKSCSQA SMEKASMEET SMGSELELAE QTEMEGAKEE
SLVEGEKEEE EETPPSPWDI HPNDVLKILE AFVMGLKKPR DSRAPPRVQK NMRNNSKDSE
YWQALTTVIP SSKQNLWDAL YTALEKYHIV LTQRAKLLLE NSSLEQRNTE LQALLQQYLN
SKINSELQVP PTQVLRVPTK
