ID   DRC1_RAT                Reviewed;         754 AA.
AC   Q5XI65;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Dynein regulatory complex protein 1;
DE   AltName: Full=Coiled-coil domain-containing protein 164;
GN   Name=Drc1; Synonyms=Ccdc164;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. Plays a critical role in the assembly of N-
CC       DRC and also stabilizes the assembly of multiple inner dynein arms and
CC       radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold
CC       needed for assembly of the N-DRC and its attachment to the outer
CC       doublet microtubules. {ECO:0000250|UniProtKB:P0DL09,
CC       ECO:0000250|UniProtKB:Q96MC2}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       {ECO:0000250|UniProtKB:P0DL09}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:P0DL09}.
CC   -!- SIMILARITY: Belongs to the DRC1 family. {ECO:0000305}.
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DR   EMBL; BC083825; AAH83825.1; -; mRNA.
DR   RefSeq; NP_001007010.1; NM_001007009.1.
DR   AlphaFoldDB; Q5XI65; -.
DR   SMR; Q5XI65; -.
DR   STRING; 10116.ENSRNOP00000031362; -.
DR   iPTMnet; Q5XI65; -.
DR   PhosphoSitePlus; Q5XI65; -.
DR   PaxDb; Q5XI65; -.
DR   PRIDE; Q5XI65; -.
DR   Ensembl; ENSRNOT00000036815; ENSRNOP00000031362; ENSRNOG00000024905.
DR   GeneID; 362712; -.
DR   KEGG; rno:362712; -.
DR   CTD; 92749; -.
DR   RGD; 1359318; Drc1.
DR   eggNOG; ENOG502QQ2B; Eukaryota.
DR   GeneTree; ENSGT00940000153804; -.
DR   HOGENOM; CLU_012489_1_0_1; -.
DR   InParanoid; Q5XI65; -.
DR   OMA; LEKSECY; -.
DR   OrthoDB; 258073at2759; -.
DR   PhylomeDB; Q5XI65; -.
DR   TreeFam; TF324985; -.
DR   PRO; PR:Q5XI65; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000024905; Expressed in testis and 6 other tissues.
DR   Genevisible; Q5XI65; RN.
DR   GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR   GO; GO:0007507; P:heart development; ISO:RGD.
DR   GO; GO:0003352; P:regulation of cilium movement; IBA:GO_Central.
DR   InterPro; IPR039505; DRC1/2_N.
DR   InterPro; IPR039750; DRC1/DRC2.
DR   InterPro; IPR029440; DRC1_C.
DR   PANTHER; PTHR21625; PTHR21625; 1.
DR   Pfam; PF14772; NYD-SP28; 1.
DR   Pfam; PF14775; NYD-SP28_assoc; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..754
FT                   /note="Dynein regulatory complex protein 1"
FT                   /id="PRO_0000277884"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          55..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          98..388
FT                   /evidence="ECO:0000255"
FT   COILED          704..743
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   754 AA;  88310 MW;  085DF289B3268FB6 CRC64;
     MNPSGSIGVL EQNGEEHLAA PILGPSVNSD NPQERIQARR LRIAARQEAR RREALGEYLD
     GKKESEEEQS KSYKQKEESR LKLTKLLLCG TELVTNIQVA ADIREIHRRV EEEETKRQRL
     EKLENEVKTS QDKFDEITSK WEEGRQKRIP QELWEMLNNQ QVHCAGLVED KNKLISELQQ
     ELKIKDDQYV KDLKKQSEDI TVLLERMEEQ VKSVMKNFRQ ELNYIEKAFE SERQELLTTN
     KKKWERALQA HNAKELEYLI NRMKRVEDYE KQLNRQRVWD CEEYNSIKIK LEQDVQILEQ
     QLQQMKATYQ LNQEKLEYNF QVLKKRDEES TVIKSQQKRK LNRLHDILNN LRTKYSKQIK
     QFQEDNQSLT SDYKRLVTQF KDLQKAIRHF IIIDQDKFRE IWLMNEAEAK ELAQRAFDVD
     KIIHSQHLGL PWKIPNFWFL NNVGPISLQQ QQKSVTQILE ELLLQSEDEG TETAMSEDES
     YMDLPNQVSA KTTKKILVLL CDESGFLIES KLLSLLLPLE KSECYLLRLD AIFSALGIES
     EDDLYKMVNF FLRFKAHHLS SAQVSISTHS NAERTSLVSA LQHMSLMSQT DRRSSASKSD
     GDPTELEDQQ GSDNGSLMGR ELVEQEDLSS PMFIHPNDVL KILDAFVTGL KKPKDARPVQ
     RLKKDTRNNL KDTEYWESLA MVIPFSKQNL WDALFKALEK YYLVLTQRAK LLMENDSLEQ
     QNAEMQSLLQ QYLQAKVNLE LQVPPTQGFR MPSK