ID   DRC1_XENLA              Reviewed;         690 AA.
AC   Q7T0Y4;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Dynein regulatory complex protein 1;
DE   AltName: Full=Coiled-coil domain-containing protein 164;
GN   Name=drc1; Synonyms=ccdc164;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. Plays a critical role in the assembly of N-
CC       DRC and also stabilizes the assembly of multiple inner dynein arms and
CC       radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold
CC       needed for assembly of the N-DRC and its attachment to the outer
CC       doublet microtubules. {ECO:0000250|UniProtKB:P0DL09,
CC       ECO:0000250|UniProtKB:Q96MC2}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       {ECO:0000250|UniProtKB:P0DL09}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:P0DL09}.
CC   -!- SIMILARITY: Belongs to the DRC1 family. {ECO:0000305}.
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DR   EMBL; BC055987; AAH55987.1; -; mRNA.
DR   RefSeq; NP_001079840.1; NM_001086371.1.
DR   AlphaFoldDB; Q7T0Y4; -.
DR   SMR; Q7T0Y4; -.
DR   DNASU; 379530; -.
DR   GeneID; 379530; -.
DR   KEGG; xla:379530; -.
DR   CTD; 379530; -.
DR   Xenbase; XB-GENE-5967074; drc1.L.
DR   OrthoDB; 258073at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 379530; Expressed in testis and 16 other tissues.
DR   GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR   InterPro; IPR039505; DRC1/2_N.
DR   InterPro; IPR039750; DRC1/DRC2.
DR   InterPro; IPR029440; DRC1_C.
DR   PANTHER; PTHR21625; PTHR21625; 1.
DR   Pfam; PF14772; NYD-SP28; 1.
DR   Pfam; PF14775; NYD-SP28_assoc; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..690
FT                   /note="Dynein regulatory complex protein 1"
FT                   /id="PRO_0000277885"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          49..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          451..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          92..419
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        451..470
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  81076 MW;  D2A5F5835F541C6B CRC64;
     MSLYERESEE SAVAGPSLDS EDQQQRIEAR RLRIVTRIEA KRREALGEDL KILKKKTEEP
     RKSHKQTEDS RQRLGKLVND GSQLVTNIQI ATDARETQRR GEEEELKRLR REKLDNEAKS
     SLEKFEEITK RWTLDKAKQV PQKMWEILNT QQQQCAQLIE DKNNLISDLQ KELRRKDDQY
     VKDLKKQAED IDLLVERMEE QIKNLIKTYR QELLQIEKVF ELERRELLTA NRNTWEQGMQ
     GRRDKELESL MSRMKKVEEY ENQLKQLRVQ DGEEYNMIKI KLETDVQILQ QQLQQMKATY
     QLNQEKLEYN YQVLKKRDEE NTITKSQQKR KITRLQDVLN NLRLKQAKQV KQYKEENQSL
     MDDYKRIVEQ YKELQKKMRH FSAVDAKMFQ DIWLMNEEEM KQLVQKALEA DQVIQEQQLG
     MCWEPPDLCF MDNVGPLLGK LKDQKSAMSL AQEVMSSHAP GDQSSASEGE TDGRQCREVS
     AETVKHILEL LCDESGFLIE NKLTRLLSPL ERDERSLIKL DSIFGALGVT VEEDVYKLVE
     FLCRYKREPE EEGDAGGSLE PGSKAHGLIH SNDVLRAVKA FVMDFQKPRG KVSRLRLMEE
     RDSREDTEYW AAAAKAIPES RFRVWDALES ALEKYYDVLG SRGQLITETV SLRQQNTELR
     TLLHQYLNSK INVELEIPPT QMMQGEYPHT