ID   DRC2_BOVIN              Reviewed;         498 AA.
AC   Q2TA16;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Dynein regulatory complex subunit 2 {ECO:0000250|UniProtKB:Q8IXS2};
DE   AltName: Full=Coiled-coil domain-containing protein 65;
GN   Name=CCDC65; Synonyms=DRC2 {ECO:0000250|UniProtKB:Q8IXS2};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. Plays a critical role in the assembly of N-
CC       DRC and also stabilizes the assembly of multiple inner dynein arms and
CC       radial spokes. Coassembles with DRC1 to form a central scaffold needed
CC       for assembly of the N-DRC and its attachment to the outer doublet
CC       microtubules. {ECO:0000250|UniProtKB:A8JB22,
CC       ECO:0000250|UniProtKB:Q8IXS2}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       {ECO:0000250|UniProtKB:A8JB22}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body
CC       {ECO:0000250|UniProtKB:A8JB22}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8JB22}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8JB22}.
CC   -!- SIMILARITY: Belongs to the DRC2 family.
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DR   EMBL; BC111168; AAI11169.1; -; mRNA.
DR   RefSeq; NP_001033255.1; NM_001038166.2.
DR   AlphaFoldDB; Q2TA16; -.
DR   SMR; Q2TA16; -.
DR   STRING; 9913.ENSBTAP00000021022; -.
DR   PaxDb; Q2TA16; -.
DR   Ensembl; ENSBTAT00000021022; ENSBTAP00000021022; ENSBTAG00000015825.
DR   GeneID; 535207; -.
DR   KEGG; bta:535207; -.
DR   CTD; 85478; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015825; -.
DR   VGNC; VGNC:26908; CCDC65.
DR   eggNOG; ENOG502QQDD; Eukaryota.
DR   GeneTree; ENSGT00940000153804; -.
DR   HOGENOM; CLU_026536_1_0_1; -.
DR   InParanoid; Q2TA16; -.
DR   OMA; QNHERDV; -.
DR   OrthoDB; 815240at2759; -.
DR   TreeFam; TF326074; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000015825; Expressed in oviduct epithelium and 74 other tissues.
DR   GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IBA:GO_Central.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR   GO; GO:0003352; P:regulation of cilium movement; IBA:GO_Central.
DR   InterPro; IPR039505; DRC1/2_N.
DR   InterPro; IPR039750; DRC1/DRC2.
DR   PANTHER; PTHR21625; PTHR21625; 1.
DR   Pfam; PF14772; NYD-SP28; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..498
FT                   /note="Dynein regulatory complex subunit 2"
FT                   /id="PRO_0000284777"
FT   COILED          98..160
FT                   /evidence="ECO:0000255"
FT   COILED          250..311
FT                   /evidence="ECO:0000255"
FT   COILED          417..441
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  58814 MW;  82B2FBBB5A20D388 CRC64;
     MSKKGKKAKV PLSDEEQLLL FQQKLLAEEE MAKKKERLLN QFLKDKLAKE EHNSALNLNK
     INTQWRTVLR EIKTRELHKD IEILSQTFER VVDCKDSVIK SLAKDLSEAE EQHAHALRSH
     LHSIDQLLAL QRCRLNLLEE NYNMELEALT KEFETERKTI IDQHEKEIHY LQDVFMAMEQ
     NYIDSEYESK LEFQSMWDDL KNKNLEEKHF LRLQLENIVE DLWRRFQDAL KNYTDATEDR
     KIAFETLKVK DEKSSREIEA QMKKIQKLQD SIIIFKGKIL VHSRESEEQN QDIREDKELV
     LVQLRKLKAQ RTQARGIAQE NLVKLTLESS ATLKALREIV DKGEKILKLA EICRKFETEE
     EKVLPFYSSV LTPKEQEEIE TMDLEEFNEE LGKVIMDYKG MENFWKRYNK VKLEQLSLRH
     RRAQLLEINE KLREMLRQYL DGISVSDEVL SQLNPLFIVN HRSNLPQLLP MPTAQPGDKK
     PPATYNIIEA AHVVSHTL