ID   DRC2_MACFA              Reviewed;         484 AA.
AC   Q4R7G7; Q95JX0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Dynein regulatory complex subunit 2 {ECO:0000250|UniProtKB:Q8IXS2};
DE   AltName: Full=Coiled-coil domain-containing protein 65;
GN   Name=CCDC65; Synonyms=DRC2 {ECO:0000250|UniProtKB:Q8IXS2};
GN   ORFNames=QtsA-12866, QtsA-15372;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 171-484.
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. Plays a critical role in the assembly of N-
CC       DRC and also stabilizes the assembly of multiple inner dynein arms and
CC       radial spokes. Coassembles with DRC1 to form a central scaffold needed
CC       for assembly of the N-DRC and its attachment to the outer doublet
CC       microtubules. {ECO:0000250|UniProtKB:A8JB22,
CC       ECO:0000250|UniProtKB:Q8IXS2}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       {ECO:0000250|UniProtKB:A8JB22}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body
CC       {ECO:0000250|UniProtKB:A8JB22}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8JB22}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8JB22}.
CC   -!- SIMILARITY: Belongs to the DRC2 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB63002.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB168851; BAE00955.1; -; mRNA.
DR   EMBL; AB070057; BAB63002.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q4R7G7; -.
DR   SMR; Q4R7G7; -.
DR   STRING; 9541.XP_005570789.1; -.
DR   eggNOG; ENOG502QQDD; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IEA:InterPro.
DR   InterPro; IPR039505; DRC1/2_N.
DR   InterPro; IPR039750; DRC1/DRC2.
DR   PANTHER; PTHR21625; PTHR21625; 1.
DR   Pfam; PF14772; NYD-SP28; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..484
FT                   /note="Dynein regulatory complex subunit 2"
FT                   /id="PRO_0000284779"
FT   COILED          92..160
FT                   /evidence="ECO:0000255"
FT   COILED          374..403
FT                   /evidence="ECO:0000255"
FT   CONFLICT        484
FT                   /note="T -> A (in Ref. 2; BAB63002)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   484 AA;  57131 MW;  6EEDA86F720B06F0 CRC64;
     MPKKEKKAKT PLSDEEQLLL FQQKLLTEEE MAKKKERLLS QFLKDKLAKE EHNSALNLNK
     INTQWRTVLR EVKTRELHKD IEILSQTFER VVDCKDNVIK SLAKDLSEAE EQYARALRSH
     LHSVDQLLAL QRHRLSLLEE SYNMELEALT KEFETERKTI IDQHEKEIHY LQDIFMAMEQ
     NYIDSEYESK LEFQSMWNDL KNMNLEEKHF LRLHLENIVE DLWRKFQDVL KNYTDATEDR
     KAAFETLQVK DEKSSKEIEV QMKKIQKLQD AITISKGKIM IHSRESEDEN RYIRNDKELV
     LVQLRKLKAQ RTQARAASQK NLVKLTLESN ATLKALRKIV DKGEKILKLA EICRKFETEE
     EKVLPFYSSV LTPKEQEGIE ENNLEELTEE LAKVMVDYTG MENFWKRYNK VKLEQLSLQH
     RRAQLLDING KLREMLKQYL DGISVSDEVL SQLNPLFIVN YQSNLPQPLS IPIAHPGDKQ
     HPTT