ID   DRC2_RAT                Reviewed;         502 AA.
AC   Q5XIJ8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Dynein regulatory complex subunit 2 {ECO:0000250|UniProtKB:Q8IXS2};
DE   AltName: Full=Coiled-coil domain-containing protein 65;
GN   Name=Ccdc65; Synonyms=Drc2 {ECO:0000250|UniProtKB:Q8IXS2};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. Plays a critical role in the assembly of N-
CC       DRC and also stabilizes the assembly of multiple inner dynein arms and
CC       radial spokes. Coassembles with DRC1 to form a central scaffold needed
CC       for assembly of the N-DRC and its attachment to the outer doublet
CC       microtubules. {ECO:0000250|UniProtKB:A8JB22,
CC       ECO:0000250|UniProtKB:Q8IXS2}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       {ECO:0000250|UniProtKB:A8JB22}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body
CC       {ECO:0000250|UniProtKB:A8JB22}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8JB22}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8JB22}.
CC   -!- SIMILARITY: Belongs to the DRC2 family.
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DR   EMBL; BC083683; AAH83683.1; -; mRNA.
DR   RefSeq; NP_001014225.1; NM_001014203.1.
DR   AlphaFoldDB; Q5XIJ8; -.
DR   SMR; Q5XIJ8; -.
DR   STRING; 10116.ENSRNOP00000050912; -.
DR   PaxDb; Q5XIJ8; -.
DR   PRIDE; Q5XIJ8; -.
DR   Ensembl; ENSRNOT00000090760; ENSRNOP00000071850; ENSRNOG00000058916.
DR   GeneID; 362994; -.
DR   KEGG; rno:362994; -.
DR   UCSC; RGD:1595842; rat.
DR   CTD; 85478; -.
DR   RGD; 1595842; Ccdc65.
DR   eggNOG; ENOG502QQDD; Eukaryota.
DR   GeneTree; ENSGT00940000153804; -.
DR   HOGENOM; CLU_026536_1_0_1; -.
DR   InParanoid; Q5XIJ8; -.
DR   OMA; QNHERDV; -.
DR   OrthoDB; 815240at2759; -.
DR   PhylomeDB; Q5XIJ8; -.
DR   TreeFam; TF326074; -.
DR   PRO; PR:Q5XIJ8; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000058916; Expressed in testis and 19 other tissues.
DR   Genevisible; Q5XIJ8; RN.
DR   GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR   GO; GO:0003352; P:regulation of cilium movement; ISO:RGD.
DR   InterPro; IPR039505; DRC1/2_N.
DR   InterPro; IPR039750; DRC1/DRC2.
DR   PANTHER; PTHR21625; PTHR21625; 1.
DR   Pfam; PF14772; NYD-SP28; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..502
FT                   /note="Dynein regulatory complex subunit 2"
FT                   /id="PRO_0000284781"
FT   COILED          96..160
FT                   /evidence="ECO:0000255"
FT   COILED          252..285
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   502 AA;  59004 MW;  0EF92278761B5026 CRC64;
     MPKKGKKPKL PLTDEEQLIL FQQKLLADEE AAKKKERLLT QFLKDKLAKE EHNSSLNLNK
     INTQWRTVLR EVKTRELHKD IEILSQIFER VVDCKDSVIK SLARDLTEAE EQYAHALRGH
     LHNVDQLLTL QRRRLSLLEE NYNMELEVLT KEFETERKAI LDHHDKEIHY LHDVFMAMEQ
     NYVDSEYESK LEFQSMWDDL KNKNLEEKHF LRLQLENVVE DLWRRFQDAL KNYTDATEDR
     KIAFETLKVK DEKSSKEIEV QMKKIQRLQE AISALKGKIV AHSREGEWQN QCIRNDKELV
     HVQLRKLKIQ RTQARTESQE NLVKLTLESN ATLKALKKVV EKGEKILKLA EICRKFETEE
     EKVLPFYSSA LTPEEQEEVE IQSQEEITED LAKIMMDYLG MENFWKRYNK VKLEVLSLQH
     RRLQLLDISS KLREMLKQYL DGISVSDEVL SRLNPLFIVN HKSNLPQLPP SAAQPGGDRG
     PGGDRRLTYN VIEAAHIASH IL