ID   DRC3_MACFA              Reviewed;         523 AA.
AC   Q4R6X9;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Dynein regulatory complex subunit 3;
DE   AltName: Full=Leucine-rich repeat-containing protein 48;
GN   Name=DRC3; Synonyms=LRRC48; ORFNames=QtsA-16881;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. {ECO:0000250|UniProtKB:A8IVX2}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       Interacts with TCTE1/DRC5 (By similarity). Interacts with DRC7 (By
CC       similarity). {ECO:0000250|UniProtKB:A8IVX2,
CC       ECO:0000250|UniProtKB:Q9D5E4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q9H069}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9H069}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8IVX2}. Cell projection, cilium,
CC       flagellum {ECO:0000250|UniProtKB:Q9D5E4}.
CC   -!- SIMILARITY: Belongs to the DRC3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB169051; BAE01145.1; -; mRNA.
DR   RefSeq; NP_001306335.1; NM_001319406.1.
DR   AlphaFoldDB; Q4R6X9; -.
DR   SMR; Q4R6X9; -.
DR   GeneID; 101865756; -.
DR   CTD; 83450; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..523
FT                   /note="Dynein regulatory complex subunit 3"
FT                   /id="PRO_0000227775"
FT   REPEAT          44..65
FT                   /note="LRR 1"
FT   REPEAT          66..87
FT                   /note="LRR 2"
FT   REPEAT          88..109
FT                   /note="LRR 3"
FT   REPEAT          110..131
FT                   /note="LRR 4"
FT   REPEAT          132..153
FT                   /note="LRR 5"
FT   DOMAIN          166..206
FT                   /note="LRRCT"
FT   COILED          358..391
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   523 AA;  61101 MW;  26669D7D67C3A459 CRC64;
     MNRLCDSMEP KVMDDDMLKL AVGEQGPQEE AGQLAKQEGI LFKDVLSLQL DFRNILRIDN
     LWQFENLRKL QLDNNIIEKI GGLENLTHLV WLDLSFNNIE TIEGLDTLVN LEDLSLFNNR
     ISKIDSLDAL VKLQVLSLGN NQIDNMMNIV YLRRFQCLRT LSLSGNPISE AEDYKMFICA
     YLPDLVYLDF RRIDDHTKEL AEAKHQYSID ELKHRENLMQ VRLQDERARQ EELEKHKTAF
     VEHLNGSFLF DSMYAEDSEG NKLSYLPGVS ELLEAYKDKF VIICMNIFEY GLKQQEKRKI
     ELDTFSECVH EAIQENQEQG KRKIAQFEEK HLSSLSAIRE ESELPNIEKM ILECSADVSE
     LFNELMMLEM QLVEQLEETI NMFERNIVDM VGLFIENVQS LMAQCRDLEN HHHEKLLEIS
     ISTLEKIVKG DLDEDLPDDL RALFVDKDTI VNAVGASHDI HLLKIDNRED ELVTRINSWC
     TRLVDKIHKD EIMRNRKRVK EINQYIDHMQ SELDNLEYSD ILD