ID   DRC3_RAT                Reviewed;         523 AA.
AC   Q5XI54;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Dynein regulatory complex subunit 3;
DE   AltName: Full=Leucine-rich repeat-containing protein 48;
GN   Name=Drc3; Synonyms=Lrrc48;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. {ECO:0000250|UniProtKB:A8IVX2}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       Interacts with TCTE1/DRC5 (By similarity). Interacts with DRC7 (By
CC       similarity). {ECO:0000250|UniProtKB:A8IVX2,
CC       ECO:0000250|UniProtKB:Q9D5E4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q9H069}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9H069}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8IVX2}. Cell projection, cilium,
CC       flagellum {ECO:0000250|UniProtKB:Q9D5E4}.
CC   -!- SIMILARITY: Belongs to the DRC3 family. {ECO:0000305}.
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DR   EMBL; BC083838; AAH83838.1; -; mRNA.
DR   RefSeq; NP_001013879.1; NM_001013857.1.
DR   RefSeq; XP_006246524.1; XM_006246462.3.
DR   RefSeq; XP_006246525.1; XM_006246463.3.
DR   RefSeq; XP_006246526.1; XM_006246464.3.
DR   RefSeq; XP_006246527.1; XM_006246465.3.
DR   RefSeq; XP_008766005.1; XM_008767783.2.
DR   RefSeq; XP_008766006.1; XM_008767784.2.
DR   AlphaFoldDB; Q5XI54; -.
DR   SMR; Q5XI54; -.
DR   STRING; 10116.ENSRNOP00000038778; -.
DR   PaxDb; Q5XI54; -.
DR   Ensembl; ENSRNOT00000032685; ENSRNOP00000038778; ENSRNOG00000021303.
DR   GeneID; 287371; -.
DR   KEGG; rno:287371; -.
DR   UCSC; RGD:1309150; rat.
DR   CTD; 83450; -.
DR   RGD; 1309150; Drc3.
DR   eggNOG; KOG0531; Eukaryota.
DR   GeneTree; ENSGT00940000159298; -.
DR   HOGENOM; CLU_026827_0_0_1; -.
DR   InParanoid; Q5XI54; -.
DR   OMA; NSFMEMM; -.
DR   OrthoDB; 568015at2759; -.
DR   PhylomeDB; Q5XI54; -.
DR   TreeFam; TF323974; -.
DR   PRO; PR:Q5XI54; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000021303; Expressed in testis and 19 other tissues.
DR   Genevisible; Q5XI54; RN.
DR   GO; GO:0005930; C:axoneme; ISO:RGD.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SMART; SM00369; LRR_TYP; 3.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..523
FT                   /note="Dynein regulatory complex subunit 3"
FT                   /id="PRO_0000227777"
FT   REPEAT          44..65
FT                   /note="LRR 1"
FT   REPEAT          66..87
FT                   /note="LRR 2"
FT   REPEAT          88..109
FT                   /note="LRR 3"
FT   REPEAT          110..131
FT                   /note="LRR 4"
FT   REPEAT          132..153
FT                   /note="LRR 5"
FT   DOMAIN          166..204
FT                   /note="LRRCT"
FT   COILED          369..393
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   523 AA;  60798 MW;  7DA36B06D0D405C5 CRC64;
     MSRPYDSMEP KVMDDDMLKV AVGEQGPQEE AGQLAKQEGI LFKDVLALQL DFQNILRIDN
     LWQFENLRKL QLNNNIIERI EGLENLTHLV WLDLSFNNIE AIEGLDTLVN LEDLSLSHNR
     ISKIDSLDPL VNLQVLSLGN NQINNMMNII YLRRFPCLRT LSLSGNPVSE AEEYKVFIYA
     YLPDLVYLDF RRVDEQAREV AKMKHQYSID ELKHREALMQ IRLEEEQAKQ QKLAEHKMAF
     VEHLNGPFLF DSMYSDDVEG NKLSYLPGVG ELLEAYKDKF VIICLNIFEY GLSQQEKRKI
     ELDTFNECIQ EAIQENQDQG KLKIAKFEEK HLLNLNAIRE ESDLFTMEQK LTECNESITE
     LFNTLMILEM QLVEQLEETI NVFERNITDL VGLFIENVQS LIAQCRDLEN HHHEKLLEIA
     INTLEKILKG EMDEDLPDDV RALFVDKDTI VNAVGASHDI HLLKIDNRED ELVTGVNSWC
     AHLVDKIHKD EIMRNRKRVK EINQFVDHMQ SELDNLECGD IID