DRC5_HUMAN
ID DRC5_HUMAN Reviewed; 501 AA.
AC Q5JU00; B4DX59; Q8IYS6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Dynein regulatory complex subunit 5 {ECO:0000250|UniProtKB:A6H639};
DE AltName: Full=T-complex-associated testis-expressed protein 1;
DE Short=Tcte-1;
GN Name=TCTE1; Synonyms=DRC5 {ECO:0000250|UniProtKB:A6H639};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-35.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-35 AND ARG-53.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. May play a role in the assembly of N-DRC.
CC May be required for sperm motility. {ECO:0000250|UniProtKB:A6H639,
CC ECO:0000250|UniProtKB:A8HMZ4}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC Interacts with FBXL13/DRC6, DRC3 and DRC7.
CC {ECO:0000250|UniProtKB:A6H639}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:A6H639}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:A8HMZ4}. Note=Detected along the length
CC of the sperm flagellum. {ECO:0000250|UniProtKB:A6H639}.
CC -!- SIMILARITY: Belongs to the DRC5 family. {ECO:0000305}.
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DR EMBL; AK301825; BAG63271.1; -; mRNA.
DR EMBL; AL353588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035022; AAH35022.1; -; mRNA.
DR CCDS; CCDS4910.1; -.
DR RefSeq; NP_872345.2; NM_182539.3.
DR RefSeq; XP_005248929.1; XM_005248872.1.
DR RefSeq; XP_011512638.1; XM_011514336.2.
DR RefSeq; XP_011512640.1; XM_011514338.2.
DR AlphaFoldDB; Q5JU00; -.
DR SMR; Q5JU00; -.
DR IntAct; Q5JU00; 80.
DR STRING; 9606.ENSP00000360560; -.
DR iPTMnet; Q5JU00; -.
DR PhosphoSitePlus; Q5JU00; -.
DR BioMuta; TCTE1; -.
DR DMDM; 74755678; -.
DR MassIVE; Q5JU00; -.
DR PaxDb; Q5JU00; -.
DR PeptideAtlas; Q5JU00; -.
DR PRIDE; Q5JU00; -.
DR Antibodypedia; 30669; 80 antibodies from 19 providers.
DR DNASU; 202500; -.
DR Ensembl; ENST00000371505.5; ENSP00000360560.4; ENSG00000146221.10.
DR GeneID; 202500; -.
DR KEGG; hsa:202500; -.
DR MANE-Select; ENST00000371505.5; ENSP00000360560.4; NM_182539.4; NP_872345.2.
DR UCSC; uc003oxi.3; human.
DR CTD; 202500; -.
DR DisGeNET; 202500; -.
DR GeneCards; TCTE1; -.
DR HGNC; HGNC:11693; TCTE1.
DR HPA; ENSG00000146221; Tissue enhanced (fallopian tube, testis).
DR MIM; 186975; gene.
DR neXtProt; NX_Q5JU00; -.
DR OpenTargets; ENSG00000146221; -.
DR PharmGKB; PA36413; -.
DR VEuPathDB; HostDB:ENSG00000146221; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159341; -.
DR HOGENOM; CLU_029623_1_0_1; -.
DR InParanoid; Q5JU00; -.
DR OMA; WINIYME; -.
DR OrthoDB; 519026at2759; -.
DR PhylomeDB; Q5JU00; -.
DR TreeFam; TF325870; -.
DR PathwayCommons; Q5JU00; -.
DR SignaLink; Q5JU00; -.
DR BioGRID-ORCS; 202500; 22 hits in 1060 CRISPR screens.
DR GenomeRNAi; 202500; -.
DR Pharos; Q5JU00; Tbio.
DR PRO; PR:Q5JU00; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5JU00; protein.
DR Bgee; ENSG00000146221; Expressed in right uterine tube and 89 other tissues.
DR ExpressionAtlas; Q5JU00; baseline and differential.
DR Genevisible; Q5JU00; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 5.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..501
FT /note="Dynein regulatory complex subunit 5"
FT /id="PRO_0000326525"
FT REPEAT 308..321
FT /note="LRR 1"
FT REPEAT 335..355
FT /note="LRR 2"
FT REPEAT 363..383
FT /note="LRR 3"
FT REPEAT 391..411
FT /note="LRR 4"
FT REPEAT 419..439
FT /note="LRR 5"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 35
FT /note="P -> L (in dbSNP:rs324146)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_040073"
FT VARIANT 53
FT /note="H -> R (in dbSNP:rs17853373)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_040074"
FT VARIANT 261
FT /note="F -> S (in dbSNP:rs2297336)"
FT /id="VAR_040075"
SQ SEQUENCE 501 AA; 55632 MW; D0948B190076A8A8 CRC64;
MQDTVTTSAL LDPSHSSVST QDNSSTGGHT SSTSPQLSKP SITPVPAKSR NPHPRANIRR
MRRIIAEDPE WSLAIVPLLT ELCIQHIIRN FQKNPILKQM LPEHQQKVLN HLSPDLPLAV
TANLIDSENY WLRCCMHRWP VCHVAHHGGS WKRMFFERHL ENLLKHFIPG TTDPAVILDL
LPLCRNYVRR VHVDQFLPPV QLPAQLRPGD QSDSGSEGEM EEPTVDHYQL GDLVAGLSHL
EELDLVYDVK DCGMNFEWNL FLFTYRDCLS LAAAIKACHT LKIFKLTRSK VDDDKARIII
RSLLDHPVLE ELDLSQNLIG DRGARGAAKL LSHSRLRVLN LANNQVRAPG AQSLAHALAH
NTNLISLNLR LNCIEDEGGQ ALAHALQTNK CLTTLHLGGN ELSEPTATLL SQVLAINTTL
TSINLSCNHI GLDGGKQLLE GMSDNKTLLE FDLRLSDVAQ ESEYLIGQAL YANREAARQR
ALNPSHFMST ITANGPENSV G
