ID   DRC5_MACFA              Reviewed;         501 AA.
AC   Q4R642;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Dynein regulatory complex subunit 5 {ECO:0000250|UniProtKB:A6H639};
DE   AltName: Full=T-complex-associated testis-expressed protein 1;
DE            Short=Tcte-1;
GN   Name=TCTE1; Synonyms=DRC5 {ECO:0000250|UniProtKB:A6H639};
GN   ORFNames=QtsA-19176;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. May play a role in the assembly of N-DRC.
CC       May be required for sperm motility. {ECO:0000250|UniProtKB:A6H639,
CC       ECO:0000250|UniProtKB:A8HMZ4}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       Interacts with FBXL13/DRC6, DRC3 and DRC7.
CC       {ECO:0000250|UniProtKB:A6H639}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A6H639}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8HMZ4}. Note=Detected along the length
CC       of the sperm flagellum. {ECO:0000250|UniProtKB:A6H639}.
CC   -!- SIMILARITY: Belongs to the DRC5 family. {ECO:0000305}.
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DR   EMBL; AB169348; BAE01433.1; -; mRNA.
DR   RefSeq; NP_001270339.1; NM_001283410.1.
DR   AlphaFoldDB; Q4R642; -.
DR   SMR; Q4R642; -.
DR   STRING; 9541.XP_005552907.1; -.
DR   GeneID; 101925424; -.
DR   CTD; 202500; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 5.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..501
FT                   /note="Dynein regulatory complex subunit 5"
FT                   /id="PRO_0000326526"
FT   REPEAT          308..321
FT                   /note="LRR 1"
FT   REPEAT          335..355
FT                   /note="LRR 2"
FT   REPEAT          363..383
FT                   /note="LRR 3"
FT   REPEAT          391..411
FT                   /note="LRR 4"
FT   REPEAT          419..439
FT                   /note="LRR 5"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  55600 MW;  954430774E21BB4C CRC64;
     MQETVTTSAL LDPSHSSVST QDKSSTGGHT SSTGPQPSKP SITPVSAKSR NPHPGANFHR
     MRRIIAEDPE WSLAIVPLLT ELCIQHIIRN FQNNPILKQM LPEHQQKVLN HLSPDLPLAV
     TSNLIDNENY WLRCCMQRWP VCHVAHHGGS WKRMFFERHL ENLLKHFIPG TTDPAVILDL
     LPLCRNYVRR VHVDQFLPPV QIPAQLRPGD QSDSGSEGEM EEPTVDHYQL GDLVAGLSHL
     EELDLVYDVK DCGMNFEWNL FLFTYRDCHS LAAAIKACHT LKIFKLTRSK VDDDKARIII
     RSLLDHPVLE ELDLSHNLIG DRGARGAAKL LNHSRLRVLN LANNQVRAPG AQSLAHALAH
     NTNLISLNLR LNCIEDEGGQ ALAHALQTNK CLTTLHLGGN ELSEPTATLL SQVLAINTTL
     TSINLSCNHI GLDGGKQLLE GMSDNKTLLE FDLRLSDVAQ ESEYLIGQAL YANREAARQR
     ALNPSHFMST ITANGPENSV G