DRC6_CHLRE
ID DRC6_CHLRE Reviewed; 260 AA.
AC A8JHD7;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Dynein regulatory complex subunit 6 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
DE AltName: Full=Flagellar associated protein 169;
GN Name=DRC6 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
GN Synonyms=FAP169;
GN ORFNames=CHLRE_12g515200v5 {ECO:0000305}, CHLREDRAFT_160224;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=23427265; DOI=10.1091/mbc.e12-11-0801;
RA Bower R., Tritschler D., Vanderwaal K., Perrone C.A., Mueller J., Fox L.,
RA Sale W.S., Porter M.E.;
RT "The N-DRC forms a conserved biochemical complex that maintains outer
RT doublet alignment and limits microtubule sliding in motile axonemes.";
RL Mol. Biol. Cell 24:1134-1152(2013).
RN [3]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=25411337; DOI=10.1091/mbc.e14-09-1367;
RA Oda T., Yanagisawa H., Kikkawa M.;
RT "Detailed structural and biochemical characterization of the nexin-dynein
RT regulatory complex.";
RL Mol. Biol. Cell 26:294-304(2015).
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes (PubMed:23427265, PubMed:25411337).
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC),
CC composed of at least DRC1, DRC2, DRC3, DRC4, DRC5, DRC6, DRC7, DRC8,
CC DRC9, DRC10 and DRC11 (PubMed:23427265, PubMed:25411337).
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC -!- SIMILARITY: Belongs to the DRC6 family. {ECO:0000305}.
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DR EMBL; DS496190; EDO96755.1; -; Genomic_DNA.
DR EMBL; CM008973; PNW75157.1; -; Genomic_DNA.
DR RefSeq; XP_001703017.1; XM_001702965.1.
DR AlphaFoldDB; A8JHD7; -.
DR STRING; 3055.EDO96755; -.
DR PaxDb; A8JHD7; -.
DR PRIDE; A8JHD7; -.
DR EnsemblPlants; PNW75157; PNW75157; CHLRE_12g515200v5.
DR GeneID; 5728527; -.
DR Gramene; PNW75157; PNW75157; CHLRE_12g515200v5.
DR KEGG; cre:CHLRE_12g515200v5; -.
DR eggNOG; ENOG502SAJE; Eukaryota.
DR HOGENOM; CLU_1070999_0_0_1; -.
DR InParanoid; A8JHD7; -.
DR OMA; LPDANTW; -.
DR OrthoDB; 1152198at2759; -.
DR Proteomes; UP000006906; Chromosome 12.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome.
FT CHAIN 1..260
FT /note="Dynein regulatory complex subunit 6"
FT /id="PRO_0000444016"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 28485 MW; 6F3ADC2D602C48F7 CRC64;
MAPKKKGGGK KKKKDDGAEP PHDGSWERAV ESGTWEKPVT DLPDANTWPT WGALRERVLT
ACREIKINNT ASLRDAFANE LVKLSPPELT LIDLRGSSNL HNFNLSPMTT CPKLTDLDLS
ECAGLDYVLL QSQTVRSVNL RKNPAITKAL IHCPRLNKLS ITDCPALETL MLWTDELTEL
DLTGCNNLSV VKLQCPNLLD SKIPPLKVAP QHVKPSHPPI ASLLKENLTT AAHKAAADKE
ALAGVKDTSD SIIPHVFRPF
