ID   DRC7_BOVIN              Reviewed;         872 AA.
AC   Q2T9M4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Dynein regulatory complex subunit 7;
DE   AltName: Full=Coiled-coil domain-containing protein 135;
DE   AltName: Full=Coiled-coil domain-containing protein lobo homolog;
GN   Name=DRC7; Synonyms=CCDC135;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes (By similarity). Involved in the regulation
CC       of flagellar motility (By similarity). Essential for male fertility,
CC       sperm head morphogenesis and sperm flagellum formation (By similarity).
CC       {ECO:0000250|UniProtKB:A8JAM0, ECO:0000250|UniProtKB:Q6V3W6}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       Interacts with TCTE1/DRC5 (By similarity). Interacts with DRC3 and
CC       GAS8/DRC4 (By similarity). {ECO:0000250|UniProtKB:A8JAM0,
CC       ECO:0000250|UniProtKB:Q6V3W6}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8JAM0}. Note=Associated with the outer
CC       doublet microtubules (OD). {ECO:0000250|UniProtKB:A8JAM0}.
CC   -!- SIMILARITY: Belongs to the DRC7 family. {ECO:0000305}.
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DR   EMBL; BC111354; AAI11355.1; -; mRNA.
DR   RefSeq; NP_001033120.1; NM_001038031.2.
DR   AlphaFoldDB; Q2T9M4; -.
DR   SMR; Q2T9M4; -.
DR   STRING; 9913.ENSBTAP00000010526; -.
DR   PaxDb; Q2T9M4; -.
DR   PRIDE; Q2T9M4; -.
DR   Ensembl; ENSBTAT00000010526; ENSBTAP00000010526; ENSBTAG00000008005.
DR   GeneID; 504736; -.
DR   KEGG; bta:504736; -.
DR   CTD; 84229; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008005; -.
DR   VGNC; VGNC:28206; DRC7.
DR   eggNOG; ENOG502QRNZ; Eukaryota.
DR   GeneTree; ENSGT00390000004913; -.
DR   HOGENOM; CLU_016052_0_0_1; -.
DR   InParanoid; Q2T9M4; -.
DR   OMA; SETMFRI; -.
DR   OrthoDB; 535554at2759; -.
DR   TreeFam; TF323665; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000008005; Expressed in oocyte and 25 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR033551; DRC7/lobo.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR35249; PTHR35249; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Differentiation; Flagellum; Reference proteome; Spermatogenesis.
FT   CHAIN           1..872
FT                   /note="Dynein regulatory complex subunit 7"
FT                   /id="PRO_0000279433"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..64
FT                   /evidence="ECO:0000255"
FT   COILED          254..292
FT                   /evidence="ECO:0000255"
FT   COILED          676..706
FT                   /evidence="ECO:0000255"
FT   COILED          780..805
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        386..401
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   872 AA;  103168 MW;  2712B35030448B34 CRC64;
     MEVLKEKVEE EEAAEREEAA ERAERGEKTK RPMEVRREET TMTQEMLRDL ERKLSEIEVS
     VPEKLLAFTK DTIDTSKLPL SYQSNTLKEE HLLQVADNFS RQYSHLCPDR VPLFLHPLNE
     CEVPKFVSTT IRPTLMPYPE LYNWDTCAQF ISDFLSMVPL PDPLKPPLYL YSSTTVLKYQ
     KGNCFDFSTL LCSMLIGAGY DAYCVNGYGS QDLCHMDLTR EVCPLTMKPK ESVKEEEKAP
     PKKYAIKPPR DLTSRFEQEQ EMKRQEAIKA EEENRRKQEE ARLLEQENAK TDPLHGLRVH
     SWVLVLSGKR EVPESFFIDP FTARSYSTQD DHFLGIESLW NHKNYWVNMQ DCWNCCKDLV
     FDLGDPVRWE YLLLGTDKPF LSLTEEEDEG MNDDDDVENL GKEDEDKSFD MPPSWVEQIE
     ISPEAFETRC PNGKKVIQYK RAKLEKWAPY LNNNGLVCRL TTYEDLECTK TLEMKEWYQN
     REDMLELKHI NKITGLNVDY FKPGHPQALR VHSYKSMQPE MDRVMEFYET ARVDGLIKRE
     ETPKTMTEHY QGRPDFLSYR HVNFGPRMKK LALNSAESNP RPMVKITERF FRNPAKPADE
     DVAERVFLIA EERIQLRYHC RSDHITANKR EFLRRTEVDS KGNKIIMTPD MCISFEVEPM
     EHTKKLLYQY EAMMKLKNEE KLSRHQAWES ELEVLEILKL REEEEEAHTL TISIYDTKRN
     EKCKEYREAM ERVLHEEHLR QVEAQLDYLA PFLAQLPPGE KLTRWQAVRL KDECLNDFKQ
     RLIDKANLIQ ARFEKETQEL QKKQQWYQEN QVTLTPEDED LYLSYCSQAM FRIRILEQRL
     SRHKELAPLK YLALEEKLYK DPRLVELLKV FV