DRC7_MACFA
ID DRC7_MACFA Reviewed; 874 AA.
AC Q95JL1; G7Q187; Q8WNU2; Q8WNU3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 3.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Dynein regulatory complex subunit 7;
DE AltName: Full=Coiled-coil domain-containing protein 135;
DE AltName: Full=Coiled-coil domain-containing protein lobo homolog;
GN Name=DRC7; Synonyms=CCDC135; ORFNames=QtsA-13114, QtsA-13183, QtsA-15805;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 323-874 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-874 (ISOFORM 2).
RC TISSUE=Testis;
RA Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K.,
RA Suzuki Y., Sugano S.;
RT "Isolation of novel full-length cDNA clones from macaque testis cDNA
RT libraries.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes (By similarity). Involved in the regulation
CC of flagellar motility (By similarity). Essential for male fertility,
CC sperm head morphogenesis and sperm flagellum formation (By similarity).
CC {ECO:0000250|UniProtKB:A8JAM0, ECO:0000250|UniProtKB:Q6V3W6}.
CC -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC Interacts with TCTE1/DRC5 (By similarity). Interacts with DRC3 and
CC GAS8/DRC4 (By similarity). {ECO:0000250|UniProtKB:A8JAM0,
CC ECO:0000250|UniProtKB:Q6V3W6}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:A8JAM0}. Note=Associated with the outer
CC doublet microtubules (OD). {ECO:0000250|UniProtKB:A8JAM0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q95JL1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q95JL1-2; Sequence=VSP_023439;
CC -!- SIMILARITY: Belongs to the DRC7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB84027.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB84028.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB070170; BAB63115.1; -; mRNA.
DR EMBL; CM001295; EHH60425.1; -; Genomic_DNA.
DR EMBL; AB066552; BAB84027.1; ALT_INIT; mRNA.
DR EMBL; AB066553; BAB84028.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q95JL1; -.
DR SMR; Q95JL1; -.
DR STRING; 9541.XP_005592115.1; -.
DR PRIDE; Q95JL1; -.
DR Ensembl; ENSMFAT00000012452; ENSMFAP00000038197; ENSMFAG00000038450. [Q95JL1-1]
DR Ensembl; ENSMFAT00000075614; ENSMFAP00000049085; ENSMFAG00000038450. [Q95JL1-2]
DR eggNOG; ENOG502QRNZ; Eukaryota.
DR GeneTree; ENSGT00390000004913; -.
DR Proteomes; UP000009130; Chromosome 20.
DR Proteomes; UP000233100; Chromosome 20.
DR Bgee; ENSMFAG00000038450; Expressed in multicellular organism.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR033551; DRC7/lobo.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR35249; PTHR35249; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Differentiation; Flagellum; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..874
FT /note="Dynein regulatory complex subunit 7"
FT /id="PRO_0000279435"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..60
FT /evidence="ECO:0000255"
FT COILED 257..297
FT /evidence="ECO:0000255"
FT COILED 688..711
FT /evidence="ECO:0000255"
FT COILED 781..807
FT /evidence="ECO:0000255"
FT COMPBIAS 389..403
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 658..694
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_023439"
FT CONFLICT 508
FT /note="P -> S (in Ref. 3; BAB84028)"
FT /evidence="ECO:0000305"
FT CONFLICT 510
FT /note="A -> T (in Ref. 1; BAB63115)"
FT /evidence="ECO:0000305"
FT CONFLICT 513
FT /note="V -> M (in Ref. 3; BAB84027)"
FT /evidence="ECO:0000305"
FT CONFLICT 791
FT /note="I -> T (in Ref. 1; BAB63115)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 874 AA; 103464 MW; 79940FD33A20E12E CRC64;
MEVLREKVEE EEEAEREEAA KRAEWARTEK MMRPVEVRKE ETTLTQEMLR DLEKKLSEIQ
IPISAELPAF TKDTIDISKL PVSYKTNTPK EEHLLQVADN FSRQYSHLCP DRVPLFLHPL
NECEVPKFVS TTLRPTLMPY PELYNWDSCA QFVSDFLTMV PLPDPLKPPS HLYSSTTVLN
YQKGNCFDFS TMLCSMLIGS GYDAYCVNGY GSLDLCHMDL TREVCPLTVK PKETVQKEEK
VLPKKYTIRP PRDLCSRFEQ EQEVKKQQEI RAQEKKQLRE EEERLMEAEK AKPDALHGLR
VHSWVLVLSG KREVPENFFI DAFTGHSYST QDERFLGIES LWNHKNYWIN MQDCWNCCKD
LIFDLGDPVR WEYMLLGTDK SQLSLTEEDD SGINDEDDVE NLGKEDEDKS FDMPHSWVEQ
IEISPEAFET RCPNGKKVIQ YKRAKLEKWA PYLNSNGLVS RLTTYEDLEC TNILEIKEWY
QNREDMLELK HINKTTDLKI DYFKPGHPQA LRVHSYKSMQ PEMDRVIEFY ETARVDGLIK
REETARTMTE YYQGRPDFLS YRHANFRPRV KKLALSSAES NPRPIVKITE QFFRNPAKPA
EEDVAERVFL LAEERIQLRY HCRDDHITAS KREFLRRTEV DSKGNKIIMT PDMCISFEVE
PMEHTKKLLY QYEAMMHLKR EEKLSRHQVW ESELEVLEIL KLREEEEAAH TLTISIYDTK
RNEKSKEYRE AMERVMHEEH LRQVETQLDY LAPFLAQLPP GEKLTRWQAV RLKDECLSDF
KQRLINKANL IQARFEKETQ ELQKKQQWYQ ENQVTLTPED EDLYLSYCSQ AMFRIRILEQ
RLNRHKELAP LKYLALEEKL YKDPRLGELQ KIFA
