ID   DRC7_PANTR              Reviewed;         874 AA.
AC   G2HE57;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Dynein regulatory complex subunit 7;
DE   AltName: Full=Coiled-coil domain-containing protein 135;
DE   AltName: Full=Coiled-coil domain-containing protein lobo homolog;
GN   Name=DRC7; Synonyms=CCDC135;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
RA   Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
RA   Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S., Hashimoto K.,
RA   Kim D.S., Park H.S.;
RT   "Major chimpanzee-specific structural changes in sperm development-
RT   associated genes.";
RL   Funct. Integr. Genomics 11:507-517(2011).
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes (By similarity). Involved in the regulation
CC       of flagellar motility (By similarity). Essential for male fertility,
CC       sperm head morphogenesis and sperm flagellum formation (By similarity).
CC       {ECO:0000250|UniProtKB:A8JAM0, ECO:0000250|UniProtKB:Q6V3W6}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       Interacts with TCTE1/DRC5 (By similarity). Interacts with DRC3 and
CC       GAS8/DRC4 (By similarity). {ECO:0000250|UniProtKB:A8JAM0,
CC       ECO:0000250|UniProtKB:Q6V3W6}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8JAM0}. Note=Associated with the outer
CC       doublet microtubules (OD). {ECO:0000250|UniProtKB:A8JAM0}.
CC   -!- TISSUE SPECIFICITY: Expressed in the testis.
CC   -!- SIMILARITY: Belongs to the DRC7 family. {ECO:0000305}.
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DR   EMBL; AK305021; BAK62015.1; -; mRNA.
DR   RefSeq; NP_001267428.1; NM_001280499.1.
DR   RefSeq; XP_016783962.1; XM_016928473.1.
DR   RefSeq; XP_016783963.1; XM_016928474.1.
DR   AlphaFoldDB; G2HE57; -.
DR   SMR; G2HE57; -.
DR   PRIDE; G2HE57; -.
DR   Ensembl; ENSPTRT00000085363; ENSPTRP00000075558; ENSPTRG00000008165.
DR   GeneID; 454123; -.
DR   KEGG; ptr:454123; -.
DR   CTD; 84229; -.
DR   VGNC; VGNC:13700; DRC7.
DR   GeneTree; ENSGT00390000004913; -.
DR   InParanoid; G2HE57; -.
DR   OrthoDB; 535554at2759; -.
DR   Proteomes; UP000002277; Chromosome 16.
DR   Bgee; ENSPTRG00000008165; Expressed in testis and 8 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR033551; DRC7/lobo.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR35249; PTHR35249; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Differentiation; Flagellum; Reference proteome; Spermatogenesis.
FT   CHAIN           1..874
FT                   /note="Dynein regulatory complex subunit 7"
FT                   /id="PRO_0000415786"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..67
FT                   /evidence="ECO:0000255"
FT   COILED          257..297
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..403
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   874 AA;  103454 MW;  E430E104249B1FCB CRC64;
     MEVLREKVEE EEEAEREEAA ERAEWARMEK MMRPVEVRKE ENTLKQETLR DLEKKLSEIQ
     ITVSAELPAF TKDTIDISKL PVSYKTNTPK EEHLLQVADN FSCQYSHLCP DRVPLFLHPL
     NECEVPKFVS TTLRPTLMPY PELYNWDSCA QFVSDFLTMV PLPDPLKPPS HLYSSTTVLK
     YQKGNCFDFS TLLCSMLIGS GYDAYCVNGY GSLDLCHMDL TREVCPLTVK PKETIKKEEK
     VLPKKYTIKP PRDLCSRFEQ EQEVKKQQEI RAQEKKRLRE EEERLMEAEK AKPDALHGLR
     VHSWVLVLSG KREVPENFFI DPFTGHSYST QDEHFLGIES LWNHKNYWIN MQDCWNCCKD
     LIFDLGDPVR WEYMLLGTDK SQLSLTEEDD SGINDEDDVE NLGKEDEDKS FDMPHSWVEQ
     IEISPEAFET RCPNGKKVIQ YKRAKLEKWA PYLNSNGLVS RLTTYEDLQC TNILEIKEWY
     QNREDMLELK HINKTTDLKT DYFKPGHPQA LRVHSYKSMQ PEMDRVIEFY ETARVDGLMK
     REETPRTMTE YYQGRPDFLS YRHASFGPRV KKLTLSSAES NPRPIVKITE RFFRNPAKPA
     EEDVAERVFL VAEERIQLRY HCREDHITAS KREFLRRTEV DSKGNKIIMT PDMCISFEVE
     PMEHTKKLLY QYEAMMHLKR EEKLSRHQVW ESELEVLEIL KLREEEEAAH TLTISIYDTK
     RNEKSKEYRE AMERMMHEEH LRQVETQLDY LAPFLAQLPP GEKLTRWQAV RLKDECLSDF
     KQRLINKANL IQARFEKETQ ELQKKQQWYQ ENQVTLTPED EDLYLSYCSQ AMFRIRILEQ
     RLNRHKELAP LKYLALEEKL YKDPRLGELQ KIFA