ID   DRC7_XENTR              Reviewed;         856 AA.
AC   Q0V9S9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Dynein regulatory complex subunit 7;
DE   AltName: Full=Coiled-coil domain-containing protein 135;
DE   AltName: Full=Coiled-coil domain-containing protein lobo homolog;
GN   Name=drc7; Synonyms=ccdc135;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes (By similarity). Involved in the regulation
CC       of flagellar motility (By similarity). Essential for male fertility,
CC       sperm head morphogenesis and sperm flagellum formation (By similarity).
CC       {ECO:0000250|UniProtKB:A8JAM0, ECO:0000250|UniProtKB:Q6V3W6}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC).
CC       {ECO:0000250|UniProtKB:A8JAM0}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:A8JAM0}. Note=Associated with the outer
CC       doublet microtubules (OD). {ECO:0000250|UniProtKB:A8JAM0}.
CC   -!- SIMILARITY: Belongs to the DRC7 family. {ECO:0000305}.
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DR   EMBL; BC121408; AAI21409.1; -; mRNA.
DR   RefSeq; NP_001072331.1; NM_001078863.1.
DR   RefSeq; XP_012816760.1; XM_012961306.2.
DR   RefSeq; XP_012816761.1; XM_012961307.2.
DR   AlphaFoldDB; Q0V9S9; -.
DR   SMR; Q0V9S9; -.
DR   PaxDb; Q0V9S9; -.
DR   DNASU; 779784; -.
DR   GeneID; 779784; -.
DR   KEGG; xtr:779784; -.
DR   CTD; 84229; -.
DR   Xenbase; XB-GENE-959992; drc7.
DR   eggNOG; ENOG502QRNZ; Eukaryota.
DR   InParanoid; Q0V9S9; -.
DR   OrthoDB; 535554at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013759; Expressed in testis and 11 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR033551; DRC7/lobo.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR35249; PTHR35249; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Differentiation; Flagellum; Reference proteome; Spermatogenesis.
FT   CHAIN           1..856
FT                   /note="Dynein regulatory complex subunit 7"
FT                   /id="PRO_0000279437"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          245..276
FT                   /evidence="ECO:0000255"
FT   COILED          661..733
FT                   /evidence="ECO:0000255"
FT   COILED          764..790
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        15..30
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   856 AA;  100419 MW;  9616FA9C076BD0AB CRC64;
     MEYLEDNKTE TFEEEDKERE EDQVLDSDEV LDSNELNDMQ ECLSQTDLSN IDNNRAIQQL
     SLGSMEFPSY TTNSEKEEML LGLADNFWHQ YTHLYPDRKP LFMCPRNECG VEKFVCTTLH
     PTLLPYSDLY DWDQSAKFVS EYLTMEPLNP PLELPRSLFS STSVLQKQSG NCFDFSVLLC
     SLLLGAGYDA YCVSGYATRE MCLMDEKRNI CPLLNKVEES SWEIPQKPLK KYTVKPPRQL
     ISKFAVQQEA KKQAKMEEAL RNEQEEETRL KEDAEKPGPD NLHGLRVHCW VLVLSGKREV
     PENFFIDALT GKSYATISEP FLGVESVWNH EDYWVNMQDC RNGCKDMKFD LGDPVCWEYL
     LQGGSKPLLL IPDEEDEEEL NGETIQENKT IFQMPPSWVL PIVIRPKEFE TRCPQGRKIL
     QYKKAKHEKW APYLKRDGHV SRLTGYLDTE CTQEVKIQDC FQNRKDKLDL REQNKIEQVT
     TEYFIPGRAD SLKVHEYRSL APETERSMMF YSEARLDGLQ RRDEKPVEMT EIYQGRADFL
     YYRHIVFGKR PKKVAIAGGP TEANPRPILK ITERFNRNKE KPANEDVAER TFLLTEDRIQ
     LRCHRKDDHI TTSYWEFLKP ANLGEKDTPI VLTPETCISY QVEPSEKFSK QLYVYETLVT
     LQQAEQNSKD NVRKSETEVR EILATRAQEE ADPQLTISIY DTERNEKSKE KREAMERAIQ
     EERQRRAVQE LDYLAPFLAQ LGDPEKLTLW QAQKVKEDCL SDMKQRLIEK ANLIQARFEK
     ETQELQKKQQ WYHQNQMSMS KEDEEAYLDY CSEAMFRIHI LETRLNRHKD LAPQKYLALE
     DRLNKDPRLR EPFLTS