ID   DRC9_CHLRE              Reviewed;         373 AA.
AC   A8HQ54;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Dynein regulatory complex protein 9 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
DE   AltName: Full=Flagellar associated protein 122;
GN   Name=DRC9 {ECO:0000303|PubMed:23427265, ECO:0000303|PubMed:25411337};
GN   Synonyms=FAP122; ORFNames=CHLREDRAFT_146448;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [2]
RP   FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=23427265; DOI=10.1091/mbc.e12-11-0801;
RA   Bower R., Tritschler D., Vanderwaal K., Perrone C.A., Mueller J., Fox L.,
RA   Sale W.S., Porter M.E.;
RT   "The N-DRC forms a conserved biochemical complex that maintains outer
RT   doublet alignment and limits microtubule sliding in motile axonemes.";
RL   Mol. Biol. Cell 24:1134-1152(2013).
RN   [3]
RP   FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=25411337; DOI=10.1091/mbc.e14-09-1367;
RA   Oda T., Yanagisawa H., Kikkawa M.;
RT   "Detailed structural and biochemical characterization of the nexin-dynein
RT   regulatory complex.";
RL   Mol. Biol. Cell 26:294-304(2015).
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes (PubMed:23427265, PubMed:25411337).
CC       {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC   -!- SUBUNIT: Component of the nexin-dynein regulatory complex (N-DRC),
CC       composed of at least DRC1, DRC2, DRC3, DRC4, DRC5, DRC6, DRC7, DRC8,
CC       DRC9, DRC10 and DRC11 (PubMed:23427265, PubMed:25411337).
CC       {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337}.
CC   -!- SIMILARITY: Belongs to the DRC9 family. {ECO:0000305}.
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DR   EMBL; DS496108; EDP09736.1; -; Genomic_DNA.
DR   RefSeq; XP_001689998.1; XM_001689946.1.
DR   AlphaFoldDB; A8HQ54; -.
DR   SMR; A8HQ54; -.
DR   STRING; 3055.EDP09736; -.
DR   PaxDb; A8HQ54; -.
DR   PRIDE; A8HQ54; -.
DR   GeneID; 5715282; -.
DR   eggNOG; ENOG502QQR7; Eukaryota.
DR   HOGENOM; CLU_742615_0_0_1; -.
DR   InParanoid; A8HQ54; -.
DR   OrthoDB; 1353340at2759; -.
DR   GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR042618; IQCG.
DR   PANTHER; PTHR14871; PTHR14871; 2.
DR   Pfam; PF00612; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum.
FT   CHAIN           1..373
FT                   /note="Dynein regulatory complex protein 9"
FT                   /id="PRO_0000444019"
FT   DOMAIN          336..365
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   COILED          145..200
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   373 AA;  42618 MW;  40C93E08F58C557D CRC64;
     MVGIDTGGKI PPEIMRQATE KTAQLAPLEG GHIYSILKQT LEKLALVGQL QVDPKVQAHE
     LTQSVGEEIS RMITEQKKLE SRFEELVALQ HVLRHQPNKT KLMENQVASE RQALQLLLSN
     CLNEIEVFGK VQPLVESVMA QQAAEQAMKE TIEREKNTTA AVRQLRNDLR EEKLDHEEKM
     KEKKKGLSTL KEQLKALKMD TAVSTRYLSK DLTAGNEHER RLQRTQLEDL LKDLGLVQQQ
     IDIEKAVHAT QAEFLRQIAA KMADDSSNWA SRHDGDLAAR EKELEMLKQQ HARDLIELKK
     AEEKFKMEQA LKKEREMKAT EERERAEFEE MRETRRAQAA VIIQAWWRGH KVRMVMSGGG
     KKGAKKGGAK KKK