DRD1_RAT
ID DRD1_RAT Reviewed; 446 AA.
AC P18901; P21669;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=D(1A) dopamine receptor;
DE AltName: Full=Dopamine D1 receptor;
GN Name=Drd1; Synonyms=Drd1a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=2168556; DOI=10.1073/pnas.87.17.6723;
RA Monsma F.J. Jr., Mahan L.C., McVittie L.D., Gerfen C.R., Sibley D.R.;
RT "Molecular cloning and expression of a D1 dopamine receptor linked to
RT adenylyl cyclase activation.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:6723-6727(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2168520; DOI=10.1038/347076a0;
RA Zhou Q.-Y., Grandy D.K., Thambi L., Kushner J.A., van Tol H.H.M., Cone R.,
RA Pribnow D., Salon J., Bunzow J.R., Civelli O.;
RT "Cloning and expression of human and rat D1 dopamine receptors.";
RL Nature 347:76-80(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1402930; DOI=10.1111/j.1471-4159.1992.tb11023.x;
RA Zhou Q.Y., Li C., Civelli O.;
RT "Characterization of gene organization and promoter region of the rat
RT dopamine D1 receptor gene.";
RL J. Neurochem. 59:1875-1883(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 114-263.
RC TISSUE=Corpus striatum;
RX PubMed=2138567; DOI=10.1016/0014-5793(90)80140-e;
RA O'Dowd B.F., Nguyen T., Tirpak A., Jarvie K.R., Israel Y., Seeman P.,
RA Niznik H.B.;
RT "Cloning of two additional catecholamine receptors from rat brain.";
RL FEBS Lett. 262:8-12(1990).
RN [5]
RP INTERACTION WITH DNAJC14, GLYCOSYLATION, MUTAGENESIS OF PHE-333; PHE-337
RP AND PHE-341, AND SUBCELLULAR LOCATION.
RX PubMed=11331877; DOI=10.1038/35074561;
RA Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.;
RT "Regulation of transport of the dopamine D1 receptor by a new membrane-
RT associated ER protein.";
RL Nat. Cell Biol. 3:492-498(2001).
CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC which activate adenylyl cyclase.
CC -!- SUBUNIT: Interacts with DNAJC14 via its C-terminus (PubMed:11331877).
CC Interacts with DRD2 (By similarity). {ECO:0000250|UniProtKB:Q61616,
CC ECO:0000269|PubMed:11331877}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11331877};
CC Multi-pass membrane protein {ECO:0000269|PubMed:11331877}. Endoplasmic
CC reticulum membrane {ECO:0000269|PubMed:11331877}; Multi-pass membrane
CC protein {ECO:0000269|PubMed:11331877}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q61616}. Cell projection, dendritic spine
CC {ECO:0000250|UniProtKB:Q61616}. Note=Transport from the endoplasmic
CC reticulum to the cell surface is regulated by interaction with DNAJC14.
CC {ECO:0000269|PubMed:11331877}.
CC -!- TISSUE SPECIFICITY: Brain, in the striatum, the nucleus accumbens, and
CC the olfactory tubercle.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:11331877}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M35077; AAA70428.1; -; mRNA.
DR EMBL; S46131; AAB23803.1; -; Genomic_DNA.
DR PIR; A36049; DYRTD1.
DR AlphaFoldDB; P18901; -.
DR SMR; P18901; -.
DR BioGRID; 246496; 5.
DR CORUM; P18901; -.
DR DIP; DIP-49024N; -.
DR IntAct; P18901; 2.
DR STRING; 10116.ENSRNOP00000034820; -.
DR BindingDB; P18901; -.
DR ChEMBL; CHEMBL265; -.
DR DrugCentral; P18901; -.
DR GuidetoPHARMACOLOGY; 214; -.
DR GlyGen; P18901; 1 site.
DR iPTMnet; P18901; -.
DR PhosphoSitePlus; P18901; -.
DR PaxDb; P18901; -.
DR RGD; 2518; Drd1.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P18901; -.
DR PhylomeDB; P18901; -.
DR PRO; PR:P18901; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IDA:RGD.
DR GO; GO:0043679; C:axon terminus; IDA:RGD.
DR GO; GO:0005901; C:caveola; IDA:RGD.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0060170; C:ciliary membrane; ISO:RGD.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0043198; C:dendritic shaft; IDA:RGD.
DR GO; GO:0043197; C:dendritic spine; IDA:RGD.
DR GO; GO:0044327; C:dendritic spine head; IDA:RGD.
DR GO; GO:0044326; C:dendritic spine neck; IDA:RGD.
DR GO; GO:0012505; C:endomembrane system; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098982; C:GABA-ergic synapse; ISO:RGD.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0016021; C:integral component of membrane; IDA:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO.
DR GO; GO:0099056; C:integral component of presynaptic membrane; IDA:SynGO.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0097730; C:non-motile cilium; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
DR GO; GO:0031701; F:angiotensin receptor binding; IPI:RGD.
DR GO; GO:0051117; F:ATPase binding; IPI:RGD.
DR GO; GO:0031750; F:D3 dopamine receptor binding; IPI:RGD.
DR GO; GO:0035240; F:dopamine binding; IMP:RGD.
DR GO; GO:0004952; F:dopamine neurotransmitter receptor activity; ISO:RGD.
DR GO; GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IDA:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:RGD.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IPI:RGD.
DR GO; GO:1901363; F:heterocyclic compound binding; IPI:RGD.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0019903; F:protein phosphatase binding; IPI:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
DR GO; GO:0005102; F:signaling receptor binding; IPI:RGD.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; ISO:RGD.
DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:BHF-UCL.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007628; P:adult walking behavior; ISO:RGD.
DR GO; GO:0008306; P:associative learning; IMP:RGD.
DR GO; GO:0014002; P:astrocyte development; ISO:RGD.
DR GO; GO:0001662; P:behavioral fear response; ISO:RGD.
DR GO; GO:0048148; P:behavioral response to cocaine; IMP:RGD.
DR GO; GO:0019722; P:calcium-mediated signaling; IDA:RGD.
DR GO; GO:0071870; P:cellular response to catecholamine stimulus; ISO:RGD.
DR GO; GO:1903351; P:cellular response to dopamine; ISO:RGD.
DR GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
DR GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; ISO:RGD.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0001661; P:conditioned taste aversion; ISO:RGD.
DR GO; GO:0021542; P:dentate gyrus development; ISO:RGD.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; ISO:RGD.
DR GO; GO:0015872; P:dopamine transport; ISO:RGD.
DR GO; GO:0042755; P:eating behavior; IDA:RGD.
DR GO; GO:0007631; P:feeding behavior; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; ISO:RGD.
DR GO; GO:0046323; P:glucose import; ISO:RGD.
DR GO; GO:0007625; P:grooming behavior; IDA:RGD.
DR GO; GO:0046959; P:habituation; ISO:RGD.
DR GO; GO:0021766; P:hippocampus development; ISO:RGD.
DR GO; GO:0043987; P:histone H3-S10 phosphorylation; ISO:RGD.
DR GO; GO:0006886; P:intracellular protein transport; IMP:RGD.
DR GO; GO:0007612; P:learning; ISO:RGD.
DR GO; GO:0007626; P:locomotory behavior; IMP:RGD.
DR GO; GO:0060292; P:long-term synaptic depression; ISO:RGD.
DR GO; GO:0060291; P:long-term synaptic potentiation; ISO:RGD.
DR GO; GO:0042711; P:maternal behavior; ISO:RGD.
DR GO; GO:0007617; P:mating behavior; ISO:RGD.
DR GO; GO:0007613; P:memory; ISO:RGD.
DR GO; GO:0099010; P:modification of postsynaptic structure; ISO:RGD.
DR GO; GO:0006936; P:muscle contraction; ISO:RGD.
DR GO; GO:0060548; P:negative regulation of cell death; IDA:RGD.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:RGD.
DR GO; GO:0042321; P:negative regulation of circadian sleep/wake cycle, sleep; IDA:RGD.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IMP:RGD.
DR GO; GO:0050805; P:negative regulation of synaptic transmission; IDA:RGD.
DR GO; GO:0019228; P:neuronal action potential; ISO:RGD.
DR GO; GO:0035106; P:operant conditioning; IMP:RGD.
DR GO; GO:0021769; P:orbitofrontal cortex development; IEP:RGD.
DR GO; GO:0030432; P:peristalsis; ISO:RGD.
DR GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; ISO:RGD.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISO:RGD.
DR GO; GO:2000253; P:positive regulation of feeding behavior; IMP:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:1900273; P:positive regulation of long-term synaptic potentiation; IMP:RGD.
DR GO; GO:0045838; P:positive regulation of membrane potential; IMP:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISO:RGD.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISO:RGD.
DR GO; GO:0099170; P:postsynaptic modulation of chemical synaptic transmission; IDA:SynGO.
DR GO; GO:0006606; P:protein import into nucleus; ISO:RGD.
DR GO; GO:0042053; P:regulation of dopamine metabolic process; ISO:RGD.
DR GO; GO:0043269; P:regulation of ion transport; IDA:RGD.
DR GO; GO:0001932; P:regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISO:RGD.
DR GO; GO:0019229; P:regulation of vasoconstriction; IMP:RGD.
DR GO; GO:0014823; P:response to activity; IEP:RGD.
DR GO; GO:0043200; P:response to amino acid; IEP:RGD.
DR GO; GO:0001975; P:response to amphetamine; IEP:RGD.
DR GO; GO:0042220; P:response to cocaine; ISO:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0032094; P:response to food; IEP:RGD.
DR GO; GO:0043278; P:response to morphine; IEP:RGD.
DR GO; GO:0035094; P:response to nicotine; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
DR GO; GO:0032526; P:response to retinoic acid; IEP:RGD.
DR GO; GO:0048545; P:response to steroid hormone; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0046960; P:sensitization; ISO:RGD.
DR GO; GO:0035176; P:social behavior; IMP:RGD.
DR GO; GO:0021756; P:striatum development; IEP:RGD.
DR GO; GO:0007416; P:synapse assembly; IEP:BHF-UCL.
DR GO; GO:0001963; P:synaptic transmission, dopaminergic; ISO:RGD.
DR GO; GO:0001659; P:temperature homeostasis; ISO:RGD.
DR GO; GO:0019226; P:transmission of nerve impulse; ISO:RGD.
DR GO; GO:0042311; P:vasodilation; IEA:InterPro.
DR GO; GO:0008542; P:visual learning; ISO:RGD.
DR InterPro; IPR001413; Dopamine_D1_rcpt.
DR InterPro; IPR000929; Dopamine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00565; DOPAMINED1AR.
DR PRINTS; PR00242; DOPAMINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Disulfide bond; Endoplasmic reticulum;
KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW Receptor; Reference proteome; Synapse; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..446
FT /note="D(1A) dopamine receptor"
FT /id="PRO_0000069378"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..299
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..312
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..337
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..446
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 347
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 351
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT MUTAGEN 333
FT /note="F->A: Loss of interaction with DNAJC14. Abolishes
FT transport to the cell surface."
FT /evidence="ECO:0000269|PubMed:11331877"
FT MUTAGEN 337
FT /note="F->A: Loss of interaction with DNAJC14. Abolishes
FT transport to the cell surface."
FT /evidence="ECO:0000269|PubMed:11331877"
FT MUTAGEN 341
FT /note="F->A: Loss of interaction with DNAJC14. Abolishes
FT transport to the cell surface."
FT /evidence="ECO:0000269|PubMed:11331877"
FT CONFLICT 91
FT /note="L -> F (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="P -> S (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="A -> T (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="L -> F (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="R -> G (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="C -> W (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 49428 MW; 0380042E8590F470 CRC64;
MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF RHLRSKVTNF
FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA FDIMCSTASI LNLCVISVDR
YWAISSPFQY ERKMTPKAAF ILISVAWTLS VLISFIPVQL SWHKAKPTWP LDGNFTSLED
TEDDNCDTRL SRTYAISSSL ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN
CQTTAGNGNP VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL CPTTNNAIET
VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED LKKEEAGGIA KPLEKLSPAL
SVILDYDTDV SLEKIQPVTH SGQHST
