ID   DRD1_XENLA              Reviewed;         451 AA.
AC   P42289;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=D(1A) dopamine receptor;
DE   AltName: Full=Dopamine D1 receptor;
GN   Name=drd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7937989; DOI=10.1073/pnas.91.22.10536;
RA   Sugamori K.S., Demchyshyn L.L., Chung M., Niznik H.B.;
RT   "D1A, D1B, and D1C dopamine receptors from Xenopus laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:10536-10540(1994).
CC   -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC       which activate adenylyl cyclase.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U07863; AAA50828.1; -; Genomic_DNA.
DR   PIR; I51659; I51659.
DR   RefSeq; XP_018107188.1; XM_018251699.1.
DR   AlphaFoldDB; P42289; -.
DR   SMR; P42289; -.
DR   GeneID; 108710578; -.
DR   KEGG; xla:108710578; -.
DR   CTD; 108710578; -.
DR   Xenbase; XB-GENE-6500264; drd1.L.
DR   OMA; MDCQQPE; -.
DR   OrthoDB; 1045889at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 108710578; Expressed in camera-type eye and 1 other tissue.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0004952; F:dopamine neurotransmitter receptor activity; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0042311; P:vasodilation; IEA:InterPro.
DR   InterPro; IPR001413; Dopamine_D1_rcpt.
DR   InterPro; IPR000929; Dopamine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00565; DOPAMINED1AR.
DR   PRINTS; PR00242; DOPAMINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..451
FT                   /note="D(1A) dopamine receptor"
FT                   /id="PRO_0000069380"
FT   TOPO_DOM        1..22
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..95
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..298
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..315
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..340
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        341..451
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   LIPID           350
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..185
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   451 AA;  50550 MW;  3A0F8AB36C166687 CRC64;
     MTFNITSMDE DVLLTERESS FRVLTGCFLS VLILSTLLGN TLVCAAVIRF RHLRSKVTNF
     FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGTFCNIWVA FDIMCSTASI LNLCVISVDR
     YWAISSPFRY ERKMTPKVAF IMIGVAWTLS VLISFIPVQL NWHKAKTTSF FDLNITLHDR
     TMDNCDSSLN RTYAISSSLI SFYIPVAIMI VTYTRIYRIA AKQIRRISAL ERAAVHAKNC
     QNSTSNRNSL DCQQPESSLK TSFKRETKVL KTLSVIMGVF VCCWLPFFIL NCIVPFCDPS
     LTTSGTEPFC ISSTTFDVFV WFGWANSSLN PIIYAFNADF RKAFSNLLGC YRLCPTSNNI
     IETVSINNNG AVVYSCQQEP KGSIPNECNL VYLIPHAIIC PEDEVLKKED ESGLSKSLEK
     MSPAFSGILD YDADVSLEKI NPITQNGQPK T