DRD5_BOVIN
ID DRD5_BOVIN Reviewed; 174 AA.
AC Q95137;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=D(1B) dopamine receptor;
DE AltName: Full=D(5) dopamine receptor;
DE AltName: Full=Dopamine D5 receptor;
DE Flags: Fragment;
GN Name=DRD5; Synonyms=DRD1B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9406867; DOI=10.1016/s0304-3940(97)00783-0;
RA Versaux-Botteri C., Gibert J.-M., Nguyen-Legros J., Vernier P.;
RT "Molecular identification of a dopamine D1b receptor in bovine retinal
RT pigment epithelium.";
RL Neurosci. Lett. 237:9-12(1997).
CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC which activate adenylyl cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U73043; AAB17282.1; -; Genomic_DNA.
DR AlphaFoldDB; Q95137; -.
DR SMR; Q95137; -.
DR STRING; 9913.ENSBTAP00000052946; -.
DR BindingDB; Q95137; -.
DR PaxDb; Q95137; -.
DR PRIDE; Q95137; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q95137; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN <1..>174
FT /note="D(1B) dopamine receptor"
FT /id="PRO_0000069404"
FT TRANSMEM <1..10
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 11..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..54
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..119
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..>174
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REGION 64..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 174
SQ SEQUENCE 174 AA; 19589 MW; C48E4F04966EE577 CRC64;
SILNLCIISV DRYWAISRPF CYERKMTQRV ALVMVGLAWT LSILISFIPV QLHWHRDKVG
SRDGLDPPSN LANGTPWEEA GESDRSAENC DSSLNRTYAI SSSLISFYIP VAIMIVTYTR
IYRIAQVQIR RISSLERAAE HAQSCRSREA CAPDSGLRAS IKKETKVLKT LSVI
