ID   DRD5_MACMU              Reviewed;         147 AA.
AC   Q95195;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=D(1B) dopamine receptor;
DE   AltName: Full=D(5) dopamine receptor;
DE   AltName: Full=Dopamine D5 receptor;
DE   Flags: Fragment;
GN   Name=DRD5; Synonyms=DRD1B;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=7476036; DOI=10.1016/0169-328x(95)00038-t;
RA   Choi W.S., Machida C.A., Ronnekleiv O.K.;
RT   "Distribution of dopamine D1, D2, and D5 receptor mRNAs in the monkey
RT   brain: ribonuclease protection assay analysis.";
RL   Brain Res. Mol. Brain Res. 31:86-94(1995).
CC   -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC       which activate adenylyl cyclase.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U13758; AAB40359.1; -; mRNA.
DR   AlphaFoldDB; Q95195; -.
DR   SMR; Q95195; -.
DR   STRING; 9544.ENSMMUP00000003732; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   InParanoid; Q95195; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0099056; C:integral component of presynaptic membrane; IDA:SynGO.
DR   GO; GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007212; P:dopamine receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..>147
FT                   /note="D(1B) dopamine receptor"
FT                   /id="PRO_0000069406"
FT   TRANSMEM        <1..12
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        13..55
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..78
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..>147
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         147
SQ   SEQUENCE   147 AA;  16627 MW;  E3C35B15FA9A0F36 CRC64;
     SILISFPVQL NWHRDQAGSW GGLDLTNNLA NWTPWEEDVW EPDVRAENCD SSLNRTYAIS
     SSLVSFYIPV AIMIVTYTRI YRIAQVQIRR ISSLERAAEH AQSCRSSAAC APDTSLRASI
     KKETKVLKTL SVIMGVFVCC WLPFFIL