DRD5_RAT
ID DRD5_RAT Reviewed; 475 AA.
AC P25115;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=D(1B) dopamine receptor;
DE AltName: Full=D(5) dopamine receptor;
DE AltName: Full=Dopamine D5 receptor;
GN Name=Drd5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=1831904; DOI=10.1073/pnas.88.17.7491;
RA Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N.,
RA Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.;
RT "Cloning, molecular characterization, and chromosomal assignment of a gene
RT encoding a second D1 dopamine receptor subtype: differential expression
RT pattern in rat brain compared with the D1A receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1991).
CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC which activate adenylyl cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Brain, in the lateral mammillary nuclei, the
CC anterior pretectal nuclei, and several layers of the hippocampus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M69118; AAA41072.1; -; Genomic_DNA.
DR PIR; A41271; A41271.
DR RefSeq; NP_036900.1; NM_012768.1.
DR AlphaFoldDB; P25115; -.
DR SMR; P25115; -.
DR BioGRID; 247243; 1.
DR STRING; 10116.ENSRNOP00000007074; -.
DR BindingDB; P25115; -.
DR ChEMBL; CHEMBL2281; -.
DR DrugCentral; P25115; -.
DR CarbonylDB; P25115; -.
DR GlyGen; P25115; 1 site.
DR PhosphoSitePlus; P25115; -.
DR PaxDb; P25115; -.
DR PRIDE; P25115; -.
DR GeneID; 25195; -.
DR KEGG; rno:25195; -.
DR CTD; 1816; -.
DR RGD; 2523; Drd5.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P25115; -.
DR OrthoDB; 1045889at2759; -.
DR PhylomeDB; P25115; -.
DR Reactome; R-RNO-390651; Dopamine receptors.
DR PRO; PR:P25115; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0030424; C:axon; IDA:RGD.
DR GO; GO:0031526; C:brush border membrane; IDA:RGD.
DR GO; GO:0060170; C:ciliary membrane; ISO:RGD.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0043197; C:dendritic spine; IDA:RGD.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IDA:SynGO.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0097730; C:non-motile cilium; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0035240; F:dopamine binding; ISO:RGD.
DR GO; GO:0004952; F:dopamine neurotransmitter receptor activity; IDA:MGI.
DR GO; GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IPI:RGD.
DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IMP:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0008306; P:associative learning; ISO:RGD.
DR GO; GO:0071870; P:cellular response to catecholamine stimulus; ISO:RGD.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; IDA:RGD.
DR GO; GO:0060292; P:long-term synaptic depression; ISO:RGD.
DR GO; GO:0007617; P:mating behavior; ISO:RGD.
DR GO; GO:0045776; P:negative regulation of blood pressure; ISO:RGD.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:RGD.
DR GO; GO:0033861; P:negative regulation of NAD(P)H oxidase activity; ISO:RGD.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IMP:RGD.
DR GO; GO:0001994; P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; ISO:RGD.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:RGD.
DR GO; GO:0045924; P:regulation of female receptivity; ISO:RGD.
DR GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; IDA:SynGO.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; ISO:RGD.
DR GO; GO:0001975; P:response to amphetamine; ISO:RGD.
DR GO; GO:0042220; P:response to cocaine; ISO:RGD.
DR GO; GO:0046960; P:sensitization; ISO:RGD.
DR GO; GO:0019226; P:transmission of nerve impulse; ISO:RGD.
DR GO; GO:0008542; P:visual learning; IMP:RGD.
DR GO; GO:0042060; P:wound healing; ISO:RGD.
DR InterPro; IPR000497; Dopamine_D5_rcpt.
DR InterPro; IPR000929; Dopamine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00566; DOPAMINED1BR.
DR PRINTS; PR00242; DOPAMINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..475
FT /note="D(1B) dopamine receptor"
FT /id="PRO_0000069408"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..102
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..317
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..357
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..475
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 415..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 370
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..211
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 475 AA; 52831 MW; 4B0C004539540D82 CRC64;
MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV WTLLGNVLVC
AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE VAGYWPFGTF CDIWVAFDIM
CSTASILNLC IISVDRYWAI SRPFRYERKM TQRVALVMVG LAWTLSILIS FIPVQLNWHR
DKAGSQGQEG LLSNGTPWEE GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT
RIYRIAQVQI RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV
CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN PIIYAFNADF
RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE IATAYVHMIP NAVSSGDREV
GEEEEEGPFD HMSQISPTTP DGDLAAESVW ELDCEEEVSL GKISPLTPNC FDKTA
