ID   DRE2C_ARATH             Reviewed;         341 AA.
AC   Q8LFR2; Q0V7R5; Q8S8E2; Q9S7X4;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Dehydration-responsive element-binding protein 2C;
DE            Short=Protein DREB2C;
GN   Name=DREB2C; Synonyms=ERF048; OrderedLocusNames=At2g40340;
GN   ORFNames=T07M07.24, T3G21.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10207155;
RA   Wang M.L., Belmonte S., Kim U., Dolan M., Morris J.W., Goodman H.M.;
RT   "A cluster of ABA-regulated genes on Arabidopsis thaliana BAC T07M07.";
RL   Genome Res. 9:325-333(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY, FUNCTION, AND INDUCTION.
RX   PubMed=11798174; DOI=10.1006/bbrc.2001.6299;
RA   Sakuma Y., Liu Q., Dubouzet J.G., Abe H., Shinozaki K.,
RA   Yamaguchi-Shinozaki K.;
RT   "DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs,
RT   transcription factors involved in dehydration- and cold-inducible gene
RT   expression.";
RL   Biochem. Biophys. Res. Commun. 290:998-1009(2002).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16407444; DOI=10.1104/pp.105.073783;
RA   Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT   "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL   Plant Physiol. 140:411-432(2006).
CC   -!- FUNCTION: Transcriptional activator that binds specifically to the DNA
CC       sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates
CC       high salinity- and abscisic acid-inducible transcription.
CC       {ECO:0000269|PubMed:11798174}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: By high-salt stress and abscisic acid (ABA) treatment.
CC       {ECO:0000269|PubMed:11798174}.
CC   -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD25951.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF085279; AAD25951.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC007020; AAD25669.2; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09816.1; -; Genomic_DNA.
DR   EMBL; BT026505; ABH04612.1; -; mRNA.
DR   EMBL; AY084695; AAM61256.1; -; mRNA.
DR   PIR; C84828; C84828.
DR   RefSeq; NP_001325151.1; NM_001336831.1.
DR   RefSeq; NP_001325152.1; NM_001336832.1.
DR   RefSeq; NP_001325154.1; NM_001336829.1.
DR   RefSeq; NP_565929.1; NM_129594.3.
DR   AlphaFoldDB; Q8LFR2; -.
DR   SMR; Q8LFR2; -.
DR   BioGRID; 3965; 5.
DR   IntAct; Q8LFR2; 2.
DR   STRING; 3702.AT2G40340.1; -.
DR   PaxDb; Q8LFR2; -.
DR   PRIDE; Q8LFR2; -.
DR   ProteomicsDB; 242294; -.
DR   EnsemblPlants; AT2G40340.1; AT2G40340.1; AT2G40340.
DR   GeneID; 818627; -.
DR   Gramene; AT2G40340.1; AT2G40340.1; AT2G40340.
DR   KEGG; ath:AT2G40340; -.
DR   Araport; AT2G40340; -.
DR   TAIR; locus:2063073; AT2G40340.
DR   eggNOG; ENOG502QTBU; Eukaryota.
DR   HOGENOM; CLU_046486_0_0_1; -.
DR   InParanoid; Q8LFR2; -.
DR   OMA; WREDNEI; -.
DR   PhylomeDB; Q8LFR2; -.
DR   PRO; PR:Q8LFR2; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8LFR2; baseline and differential.
DR   Genevisible; Q8LFR2; AT.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0010286; P:heat acclimation; IEP:TAIR.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR   CDD; cd00018; AP2; 1.
DR   Gene3D; 3.30.730.10; -; 1.
DR   InterPro; IPR001471; AP2/ERF_dom.
DR   InterPro; IPR036955; AP2/ERF_dom_sf.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   Pfam; PF00847; AP2; 1.
DR   PRINTS; PR00367; ETHRSPELEMNT.
DR   SMART; SM00380; AP2; 1.
DR   SUPFAM; SSF54171; SSF54171; 1.
DR   PROSITE; PS51032; AP2_ERF; 1.
PE   2: Evidence at transcript level;
KW   Abscisic acid signaling pathway; Activator; DNA-binding; Nucleus;
KW   Reference proteome; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Dehydration-responsive element-binding protein 2C"
FT                   /id="PRO_0000112536"
FT   DNA_BIND        71..128
FT                   /note="AP2/ERF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT   REGION          36..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           8..48
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        74
FT                   /note="G -> E (in Ref. 4; AAM61256)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   341 AA;  37830 MW;  3B854E8B86A05D3C CRC64;
     MPSEIVDRKR KSRGTRDVAE ILRQWREYNE QIEAESCIDG GGPKSIRKPP PKGSRKGCMK
     GKGGPENGIC DYRGVRQRRW GKWVAEIREP DGGARLWLGT FSSSYEAALA YDEAAKAIYG
     QSARLNLPEI TNRSSSTAAT ATVSGSVTAF SDESEVCARE DTNASSGFGQ VKLEDCSDEY
     VLLDSSQCIK EELKGKEEVR EEHNLAVGFG IGQDSKRETL DAWLMGNGNE QEPLEFGVDE
     TFDINELLGI LNDNNVSGQE TMQYQVDRHP NFSYQTQFPN SNLLGSLNPM EIAQPGVDYG
     CPYVQPSDME NYGIDLDHRR FNDLDIQDLD FGGDKDVHGS T