ID   DRG2_DICDI              Reviewed;         364 AA.
AC   Q54WT4;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Developmentally-regulated GTP-binding protein 2 homolog;
DE            Short=DRG-2;
GN   Name=drg2; ORFNames=DDB_G0279451;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. {ECO:0000255|PROSITE-ProRule:PRU01047}.
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DR   EMBL; AAFI02000031; EAL67664.1; -; Genomic_DNA.
DR   RefSeq; XP_641633.1; XM_636541.1.
DR   AlphaFoldDB; Q54WT4; -.
DR   SMR; Q54WT4; -.
DR   STRING; 44689.DDB0205772; -.
DR   PaxDb; Q54WT4; -.
DR   EnsemblProtists; EAL67664; EAL67664; DDB_G0279451.
DR   GeneID; 8622039; -.
DR   KEGG; ddi:DDB_G0279451; -.
DR   dictyBase; DDB_G0279451; drg2.
DR   eggNOG; KOG1486; Eukaryota.
DR   HOGENOM; CLU_044997_0_0_1; -.
DR   InParanoid; Q54WT4; -.
DR   OMA; VCDQVHR; -.
DR   PhylomeDB; Q54WT4; -.
DR   PRO; PR:Q54WT4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   CDD; cd01896; DRG; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR045001; DRG.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR031662; GTP-binding_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   PANTHER; PTHR43127; PTHR43127; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF16897; MMR_HSR1_Xtn; 1.
DR   Pfam; PF02824; TGS; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81271; SSF81271; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51710; G_OBG; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..364
FT                   /note="Developmentally-regulated GTP-binding protein 2
FT                   homolog"
FT                   /id="PRO_0000351221"
FT   DOMAIN          63..288
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   DOMAIN          288..363
FT                   /note="TGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01228"
FT   BINDING         69..76
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         115..119
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         246..249
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ   SEQUENCE   364 AA;  40716 MW;  C75AEED9F5D500FA CRC64;
     MGILEKIKDI EAEMSRTQKN KATEYHLGLL KAKLARLRQQ LLDPPKSSGK GGDGFEVLKS
     GDARVALIGF PSVGKSTILT KLTETKSLAA AYEFTTLTCI PGVIQHKGAR IQLLDTPGII
     EGASQGRGRG RQVIAVARTA DLILMMLDAN KGEIQKRLLQ EELESIGIRL NSQPPNIYFK
     LKSAGGVNLT ATQTLTKITE KLAKSILHEY KIFNCDLVIR CDPTVDELID AIEGRRSYIR
     CLYVYNKMDH MSMEDVDRLS RQPNSVVISC NMNLNLDFLL DKIWDYLNLV RVYTKLRGAS
     PDFNDAIILR EGATMEDICR FLHKELVSQF KYGIVWGVSA KHCPQRVGIS HALEDEDVIQ
     IVKK