ID   DRGA_SYNY3              Reviewed;         210 AA.
AC   Q55233; P73850;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Protein DrgA;
GN   Name=drgA; OrderedLocusNames=slr1719;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9654132; DOI=10.1016/s0014-5793(98)00528-6;
RA   Elanskaya I.V., Chesnavichene E.A., Vernotte C., Astier C.;
RT   "Resistance to nitrophenolic herbicides and metronidazole in the
RT   cyanobacterium Synechocystis sp. PCC 6803 as a result of the inactivation
RT   of a nitroreductase-like protein encoded by drgA gene.";
RL   FEBS Lett. 428:188-192(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-17.
RX   PubMed=9298645; DOI=10.1002/elps.1150180806;
RA   Sazuka T., Ohara O.;
RT   "Towards a proteome project of cyanobacterium Synechocystis sp. strain
RT   PCC6803: linking 130 protein spots with their respective genes.";
RL   Electrophoresis 18:1252-1258(1997).
CC   -!- FUNCTION: Controls resistance to the herbicide Dinoseb and
CC       metronidazole. Involved in detoxification of Dinoseb via the reduction
CC       of the nitro group(s) and this process is accompanied by the formation
CC       of toxic superoxide anions.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; L29426; AAA91952.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA17909.1; -; Genomic_DNA.
DR   PIR; S75047; S75047.
DR   AlphaFoldDB; Q55233; -.
DR   SMR; Q55233; -.
DR   IntAct; Q55233; 1.
DR   STRING; 1148.1652992; -.
DR   EnsemblBacteria; BAA17909; BAA17909; BAA17909.
DR   KEGG; syn:slr1719; -.
DR   eggNOG; COG0778; Bacteria.
DR   InParanoid; Q55233; -.
DR   PhylomeDB; Q55233; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0009635; P:response to herbicide; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Flavoprotein; FMN; Herbicide resistance; NAD;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Protein DrgA"
FT                   /id="PRO_0000072722"
FT   CONFLICT        31
FT                   /note="H -> L (in Ref. 2; BAA17909)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        45
FT                   /note="L -> H (in Ref. 2; BAA17909)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        183..210
FT                   /note="PGKRRSNSPGRIPLGKLLCLTKVWCLAI -> RAKGGQTPLEELVWENSF
FT                   (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  23703 MW;  C29A1293996EBB95 CRC64;
     MDTFDAIYQR RSVKHFDPDH RLTAEEERKL HEAAIQAPTS FNIQLWRFLI IRDPQLRQTI
     REKYGNQAQM TDASLLILVA ADVNAWDKDP ARYWRNAPRE VANYLVGAIA SFYGGKPQLQ
     RDEAQRSIGM AMQNLMLAAK AMGYDSCPMI GFDLQKVAEL VKLPADYAIG PMVAIGKRTE
     DAPGKRRSNS PGRIPLGKLL CLTKVWCLAI