DRGX_HUMAN
ID DRGX_HUMAN Reviewed; 263 AA.
AC A6NNA5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Dorsal root ganglia homeobox protein;
DE AltName: Full=Paired-related homeobox protein-like 1;
GN Name=DRGX; Synonyms=PRRXL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor required for the formation of correct
CC projections from nociceptive sensory neurons to the dorsal horn of the
CC spinal cord and normal perception of pain. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RGMB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AC027674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471187; EAW93100.1; -; Genomic_DNA.
DR CCDS; CCDS44388.2; -.
DR RefSeq; NP_001263380.1; NM_001276451.1.
DR AlphaFoldDB; A6NNA5; -.
DR SMR; A6NNA5; -.
DR STRING; 9606.ENSP00000363254; -.
DR iPTMnet; A6NNA5; -.
DR PhosphoSitePlus; A6NNA5; -.
DR BioMuta; DRGX; -.
DR MassIVE; A6NNA5; -.
DR PaxDb; A6NNA5; -.
DR PeptideAtlas; A6NNA5; -.
DR PRIDE; A6NNA5; -.
DR ProteomicsDB; 1595; -.
DR Antibodypedia; 27592; 160 antibodies from 22 providers.
DR DNASU; 644168; -.
DR Ensembl; ENST00000374139.8; ENSP00000363254.1; ENSG00000165606.10.
DR GeneID; 644168; -.
DR KEGG; hsa:644168; -.
DR MANE-Select; ENST00000374139.8; ENSP00000363254.1; NM_001276451.2; NP_001263380.1.
DR UCSC; uc021pqd.2; human.
DR CTD; 644168; -.
DR DisGeNET; 644168; -.
DR GeneCards; DRGX; -.
DR HGNC; HGNC:21536; DRGX.
DR HPA; ENSG00000165606; Group enriched (adrenal gland, brain).
DR MIM; 606701; gene.
DR neXtProt; NX_A6NNA5; -.
DR OpenTargets; ENSG00000165606; -.
DR VEuPathDB; HostDB:ENSG00000165606; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000159008; -.
DR HOGENOM; CLU_079091_0_0_1; -.
DR InParanoid; A6NNA5; -.
DR OMA; FGNHAPT; -.
DR OrthoDB; 1097815at2759; -.
DR PhylomeDB; A6NNA5; -.
DR PathwayCommons; A6NNA5; -.
DR SignaLink; A6NNA5; -.
DR BioGRID-ORCS; 644168; 13 hits in 1089 CRISPR screens.
DR GenomeRNAi; 644168; -.
DR Pharos; A6NNA5; Tbio.
DR PRO; PR:A6NNA5; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; A6NNA5; protein.
DR Bgee; ENSG00000165606; Expressed in superior frontal gyrus and 30 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0009593; P:detection of chemical stimulus; IEA:Ensembl.
DR GO; GO:0016048; P:detection of temperature stimulus; IEA:Ensembl.
DR GO; GO:0021516; P:dorsal spinal cord development; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050954; P:sensory perception of mechanical stimulus; IEA:Ensembl.
DR GO; GO:0021559; P:trigeminal nerve development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..263
FT /note="Dorsal root ganglia homeobox protein"
FT /id="PRO_0000300814"
FT DNA_BIND 33..92
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 88..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 204..217
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
SQ SEQUENCE 263 AA; 28672 MW; 7FF77B9C4763EDE6 CRC64;
MFYFHCPPQL EGTATFGNHS SGDFDDGFLR RKQRRNRTTF TLQQLEALEA VFAQTHYPDV
FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP GAKEPMAEVT PPPVRNINSP
PPGDQARSKK EALEAQQSLG RTVGPAGPFF PSCLPGTLLN TATYAQALSH VASLKGGPLC
SCCVPDPMGL SFLPTYGCQS NRTASVATLR MKAREHSEAV LQSANLLPST SSSPGPVAKP
APPDGSQEKT SPTKEQSEAE KSV
