ID   DRGX_RAT                Reviewed;         263 AA.
AC   Q62798;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 133.
DE   RecName: Full=Dorsal root ganglia homeobox protein;
DE   AltName: Full=Dorsal root ganglion 11;
DE   AltName: Full=Homeobox protein DRG11;
DE   AltName: Full=Paired-related homeobox protein-like 1;
GN   Name=Drgx; Synonyms=Drg11, Prrxl1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Spinal ganglion;
RX   PubMed=7496632; DOI=10.1006/mcne.1995.1022;
RA   Saito T., Greenwood A., Sun Q., Anderson D.J.;
RT   "Identification by differential RT-PCR of a novel paired homeodomain
RT   protein specifically expressed in sensory neurons and a subset of their CNS
RT   targets.";
RL   Mol. Cell. Neurosci. 6:280-292(1995).
CC   -!- FUNCTION: Transcription factor required for the formation of correct
CC       projections from nociceptive sensory neurons to the dorsal horn of the
CC       spinal cord and normal perception of pain. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RGMB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- TISSUE SPECIFICITY: Expressed in most sensory neurons but not in
CC       autonomic neurons. Also expressed in the dorsal horn of the spinal
CC       cord.
CC   -!- DEVELOPMENTAL STAGE: First detected at E12.5 in the nervous system and
CC       in the dorsal root ganglia of the trunk region. By E15.5, strong
CC       expression in trunk and dorsal spinal cord and at E17.5 expression
CC       increases in the dorsal horns.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; U29174; AAA87203.1; -; mRNA.
DR   RefSeq; NP_665710.1; NM_145767.1.
DR   AlphaFoldDB; Q62798; -.
DR   SMR; Q62798; -.
DR   STRING; 10116.ENSRNOP00000027186; -.
DR   PhosphoSitePlus; Q62798; -.
DR   PaxDb; Q62798; -.
DR   GeneID; 252880; -.
DR   KEGG; rno:252880; -.
DR   UCSC; RGD:628616; rat.
DR   CTD; 644168; -.
DR   RGD; 628616; Drgx.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q62798; -.
DR   OrthoDB; 1097815at2759; -.
DR   PhylomeDB; Q62798; -.
DR   PRO; PR:Q62798; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0007411; P:axon guidance; ISO:RGD.
DR   GO; GO:0007409; P:axonogenesis; ISO:RGD.
DR   GO; GO:0009593; P:detection of chemical stimulus; ISO:RGD.
DR   GO; GO:0016048; P:detection of temperature stimulus; ISO:RGD.
DR   GO; GO:0021516; P:dorsal spinal cord development; ISO:RGD.
DR   GO; GO:0007399; P:nervous system development; ISO:RGD.
DR   GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR   GO; GO:0001764; P:neuron migration; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0050954; P:sensory perception of mechanical stimulus; ISO:RGD.
DR   GO; GO:0021559; P:trigeminal nerve development; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..263
FT                   /note="Dorsal root ganglia homeobox protein"
FT                   /id="PRO_0000049258"
FT   DNA_BIND        33..92
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          88..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           204..217
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        222..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  28621 MW;  195DBB44D5953D6F CRC64;
     MFYFHCPPQL EGTAPFGNHS TGDFDDGFLR RKQRRNRTTF ALQQLEALEA VFAQTHYPDV
     FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP GAKEPMAEVT PPPVRNINSP
     PPGDQARGKK EALEAQQSLG RTVGPAGPFF PSCLPGTLLN TATYAQALSH VASLKGGPLC
     SCCVPDPMGL SFLPTYGCQS NRTASVAALR MKAREHSEAV LQSANLLPST SSSPGPASKQ
     VPPEGSQDKP SPTKEQSEGE KSV