DRIC1_HUMAN
ID DRIC1_HUMAN Reviewed; 229 AA.
AC Q6PGQ1; Q6ICJ8; Q6P4I3; Q9NU31;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Aspartate-rich protein 1;
GN Name=DRICH1; Synonyms=C22orf43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6PGQ1; P48730: CSNK1D; NbExp=3; IntAct=EBI-10253641, EBI-751621;
CC Q6PGQ1; Q9Y6M4-3: CSNK1G3; NbExp=3; IntAct=EBI-10253641, EBI-11045281;
CC Q6PGQ1; Q9NPC6: MYOZ2; NbExp=3; IntAct=EBI-10253641, EBI-746712;
CC Q6PGQ1; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10253641, EBI-10313866;
CC Q6PGQ1; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10253641, EBI-11955083;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB75693.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; CR456370; CAG30256.1; -; mRNA.
DR EMBL; AL080197; CAB75693.1; ALT_SEQ; mRNA.
DR EMBL; AP000346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC056888; AAH56888.1; -; mRNA.
DR CCDS; CCDS42985.1; -.
DR RefSeq; NP_057533.2; NM_016449.3.
DR AlphaFoldDB; Q6PGQ1; -.
DR BioGRID; 119396; 11.
DR IntAct; Q6PGQ1; 8.
DR STRING; 9606.ENSP00000316137; -.
DR GlyGen; Q6PGQ1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6PGQ1; -.
DR PhosphoSitePlus; Q6PGQ1; -.
DR BioMuta; DRICH1; -.
DR DMDM; 74737656; -.
DR MassIVE; Q6PGQ1; -.
DR PaxDb; Q6PGQ1; -.
DR PeptideAtlas; Q6PGQ1; -.
DR PRIDE; Q6PGQ1; -.
DR ProteomicsDB; 67119; -.
DR Antibodypedia; 5253; 40 antibodies from 8 providers.
DR DNASU; 51233; -.
DR Ensembl; ENST00000317749.9; ENSP00000316137.5; ENSG00000189269.12.
DR Ensembl; ENST00000614553.1; ENSP00000483208.1; ENSG00000189269.12.
DR GeneID; 51233; -.
DR KEGG; hsa:51233; -.
DR MANE-Select; ENST00000317749.9; ENSP00000316137.5; NM_016449.4; NP_057533.2.
DR UCSC; uc002zxf.3; human.
DR CTD; 51233; -.
DR DisGeNET; 51233; -.
DR GeneCards; DRICH1; -.
DR HGNC; HGNC:28031; DRICH1.
DR HPA; ENSG00000189269; Tissue enhanced (epididymis, testis).
DR neXtProt; NX_Q6PGQ1; -.
DR OpenTargets; ENSG00000189269; -.
DR PharmGKB; PA164717092; -.
DR VEuPathDB; HostDB:ENSG00000189269; -.
DR eggNOG; ENOG502TEMG; Eukaryota.
DR GeneTree; ENSGT00520000056310; -.
DR HOGENOM; CLU_1389796_0_0_1; -.
DR InParanoid; Q6PGQ1; -.
DR OMA; SNCGWPR; -.
DR OrthoDB; 990299at2759; -.
DR PhylomeDB; Q6PGQ1; -.
DR TreeFam; TF340710; -.
DR PathwayCommons; Q6PGQ1; -.
DR SignaLink; Q6PGQ1; -.
DR BioGRID-ORCS; 51233; 15 hits in 1012 CRISPR screens.
DR ChiTaRS; DRICH1; human.
DR GenomeRNAi; 51233; -.
DR Pharos; Q6PGQ1; Tdark.
DR PRO; PR:Q6PGQ1; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6PGQ1; protein.
DR Bgee; ENSG00000189269; Expressed in sperm and 92 other tissues.
DR Genevisible; Q6PGQ1; HS.
DR InterPro; IPR042865; DRICH1-like.
DR PANTHER; PTHR15880; PTHR15880; 2.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..229
FT /note="Aspartate-rich protein 1"
FT /id="PRO_0000319592"
FT REGION 84..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 4
FT /note="I -> T (in dbSNP:rs3827318)"
FT /id="VAR_039014"
FT CONFLICT 120
FT /note="Missing (in Ref. 1; CAG30256)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 229 AA; 25064 MW; BB7B6F201690A1F2 CRC64;
MGNILTCCIN SHCGWPRGKD APCYESDTDI YETVAAATSE STTVEPGKLD VGATEGQDLQ
HISNQKMPTG PPEDRLSLKF LPSSEEDNDD AKILPSPVQG SSEDNLSLVC LPRSEDDDCD
DDDDDDAQIL PSRVQGGCYR FDSSSCSSED NLSLVCLPRS EDDDCDDDDD DAQILPSPVQ
ACSEDSLFLR CSLRHKDEEE EDDDDIHITA RIESDLTLES LSDEEIHPG
