ID   DRI_STRPU               Reviewed;         490 AA.
AC   Q8MQH7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Protein dead ringer homolog;
DE   AltName: Full=Deadringer-like protein;
DE   AltName: Full=Spdeadringer;
DE            Short=Spdri;
GN   Name=dri;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=12941621; DOI=10.1016/s0012-1606(03)00278-1;
RA   Amore G., Yavrouian R.G., Peterson K.J., Ransick A., McClay D.R.,
RA   Davidson E.H.;
RT   "Spdeadringer, a sea urchin embryo gene required separately in skeletogenic
RT   and oral ectoderm gene regulatory networks.";
RL   Dev. Biol. 261:55-81(2003).
CC   -!- FUNCTION: Transcription factor involved in skeletogenesis and oral
CC       ectoderm patterning. {ECO:0000269|PubMed:12941621}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the precursors of the skeletogenic or
CC       primary mesenchyme cells of the early to mid blastula, and thereafter
CC       in the presumptive and then definitive oral ectoderm. In the post-
CC       gastrular embryo, expressed in apical plate and ciliary band.
CC       {ECO:0000269|PubMed:12941621}.
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DR   EMBL; AY130972; AAM81746.1; -; mRNA.
DR   RefSeq; NP_999799.1; NM_214634.2.
DR   AlphaFoldDB; Q8MQH7; -.
DR   SMR; Q8MQH7; -.
DR   STRING; 7668.SPU_005718-tr; -.
DR   PRIDE; Q8MQH7; -.
DR   GeneID; 373505; -.
DR   CTD; 373505; -.
DR   eggNOG; KOG2744; Eukaryota.
DR   HOGENOM; CLU_026952_0_2_1; -.
DR   InParanoid; Q8MQH7; -.
DR   OrthoDB; 1347369at2759; -.
DR   PhylomeDB; Q8MQH7; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.150.60; -; 1.
DR   InterPro; IPR045147; ARI3A/B/C.
DR   InterPro; IPR001606; ARID_dom.
DR   InterPro; IPR036431; ARID_dom_sf.
DR   InterPro; IPR023334; REKLES_domain.
DR   PANTHER; PTHR15348; PTHR15348; 1.
DR   Pfam; PF01388; ARID; 1.
DR   SMART; SM00501; BRIGHT; 1.
DR   SUPFAM; SSF46774; SSF46774; 1.
DR   PROSITE; PS51011; ARID; 1.
DR   PROSITE; PS51486; REKLES; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..490
FT                   /note="Protein dead ringer homolog"
FT                   /id="PRO_0000295165"
FT   DOMAIN          202..294
FT                   /note="ARID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT   DOMAIN          389..479
FT                   /note="REKLES"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00819"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..53
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..364
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  56206 MW;  B9CA954BF96E8161 CRC64;
     MVEDQRRQLM EEEDEERRLI LEEQRRRMMR ADRDEEEEEE EEEEEEEREE DDGRRSEDEM
     REDEPPGRRE TSHAHIDLNM MRANAHLKEM MDKNRRFVST RLEEPITQSP PLTNGSNHDN
     DHDPYLSHRA AHGGSPDLPH SYMKAAHPLI KKEDGIAKME MDIGLKDEMK MGAGLEDRDG
     DKPQTEWSFE EQFKQLYELS TDSKRKEFLD DLFSYMQKRG TPVNRIPIMA KQVLDLYELY
     NLVVAKGGLV EVINKKQWRE ITKGLNLPAS ITSAAFTLRT QYMKYLYPYE CEKKGLSSPS
     ELQSAIDGNR REGRRPSYHS PHMHPRGPSL AYHHGLDLHT PSGSPPPTMI PHPSRIPTLP
     PRLSPSTSPI EDDHPVPLGF PRQGTLSHAA MLAELAERGS IPPPSKRSLL AEEHHHRLLQ
     LQQQHLVMPT AHLKVSSARA HPENGMPLFE MRGDNSLVMS IELNSVLYQG VLYPRGGTRS
     SLDRDTSTPV