ID   DRK_DROSI               Reviewed;         211 AA.
AC   Q6YKA8;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein E(sev)2B;
DE   AltName: Full=Downstream of receptor kinase;
DE   AltName: Full=Protein enhancer of sevenless 2B;
DE   AltName: Full=SH2-SH3 adapter protein drk;
GN   Name=drk; Synonyms=E(sev)2B;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SIM31;
RX   PubMed=12694293; DOI=10.1046/j.1365-294x.2003.01741.x;
RA   Riley R.M., Jin W., Gibson G.;
RT   "Contrasting selection pressures on components of the Ras-mediated signal
RT   transduction pathway in Drosophila.";
RL   Mol. Ecol. 12:1315-1323(2003).
CC   -!- FUNCTION: Required for proper signaling by sevenless. May act to
CC       stimulate the ability of Sos to catalyze Ras1 activation by linking
CC       sevenless and Sos in a signaling complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with autophosphorylated sev via SH2 domain and Sos
CC       and Dab via SH3 domains. Binds to tyrosine phosphorylated Dab via the
CC       SH2 domain (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
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DR   EMBL; AY135137; AAN17586.1; -; Genomic_DNA.
DR   EMBL; AY135136; AAN17586.1; JOINED; Genomic_DNA.
DR   RefSeq; XP_016027399.1; XM_016182127.1.
DR   RefSeq; XP_016027400.1; XM_016182128.1.
DR   AlphaFoldDB; Q6YKA8; -.
DR   SMR; Q6YKA8; -.
DR   EnsemblMetazoa; FBtr0358051; FBpp0322090; FBgn0063984.
DR   EnsemblMetazoa; FBtr0359196; FBpp0323130; FBgn0063984.
DR   GeneID; 6734328; -.
DR   ChiTaRS; drk; fly.
DR   Bgee; FBgn0063984; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0098793; C:presynapse; IEA:EnsemblMetazoa.
DR   GO; GO:0032991; C:protein-containing complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:EnsemblMetazoa.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:EnsemblMetazoa.
DR   GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
DR   GO; GO:0005118; F:sevenless binding; IEA:EnsemblMetazoa.
DR   GO; GO:0030159; F:signaling receptor complex adaptor activity; ISS:UniProtKB.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0007427; P:epithelial cell migration, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0051179; P:localization; IEA:UniProt.
DR   GO; GO:0008355; P:olfactory learning; IEA:EnsemblMetazoa.
DR   GO; GO:0030707; P:ovarian follicle cell development; IEA:EnsemblMetazoa.
DR   GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:EnsemblMetazoa.
DR   GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0007265; P:Ras protein signal transduction; IEA:EnsemblMetazoa.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:EnsemblMetazoa.
DR   GO; GO:0045500; P:sevenless signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007614; P:short-term memory; IEA:EnsemblMetazoa.
DR   GO; GO:0008293; P:torso signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0007426; P:tracheal outgrowth, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR030219; Grb2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR19969:SF19; PTHR19969:SF19; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF50044; SSF50044; 2.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   3: Inferred from homology;
KW   Membrane; Repeat; SH2 domain; SH3 domain; Transducer.
FT   CHAIN           1..211
FT                   /note="Protein E(sev)2B"
FT                   /id="PRO_0000088211"
FT   DOMAIN          1..58
FT                   /note="SH3 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          60..151
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   DOMAIN          152..211
FT                   /note="SH3 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
SQ   SEQUENCE   211 AA;  24435 MW;  A1D0614AF358F3C0 CRC64;
     MEAIAKHDFS ATADDELSFR KTQILKILNM EDDSNWYRAE LDGKEGLIPS NYIEMKNHDW
     YYGRITRADA EKLLSNKHEG AFLIRISESS PGDFSLSVKC PDGVQHFKVL RDAQSKFFLW
     VVKFNSLNEL VEYHRTASVS RSQDVKLRDM IPEEMLVQAL YDFVPQESGE LDFRRGDVIT
     VTDRSDENWW NGEIGNRKGI FPATYVTPYH S