DRL12_ARATH
ID DRL12_ARATH Reviewed; 870 AA.
AC Q9LQ54; F4ID11; Q9SLT7;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable disease resistance protein At1g59620;
DE AltName: Full=CW9;
GN OrderedLocusNames=At1g59620; ORFNames=T30E16.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=10548732; DOI=10.1016/s0378-1119(99)00403-5;
RA Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.;
RT "Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana
RT genomic region located around the 100 map unit of chromosome 1.";
RL Gene 239:309-316(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LQ54-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LQ54-2; Sequence=VSP_042239, VSP_042240, VSP_042241;
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79754.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB028231; BAA87956.1; -; mRNA.
DR EMBL; AC009317; AAF79754.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; T52429; T52429.
DR AlphaFoldDB; Q9LQ54; -.
DR SMR; Q9LQ54; -.
DR BioGRID; 27477; 1.
DR STRING; 3702.AT1G59620.1; -.
DR PRIDE; Q9LQ54; -.
DR ProteomicsDB; 224309; -. [Q9LQ54-1]
DR Araport; AT1G59620; -.
DR eggNOG; KOG4658; Eukaryota.
DR InParanoid; Q9LQ54; -.
DR OrthoDB; 164862at2759; -.
DR PRO; PR:Q9LQ54; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LQ54; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..870
FT /note="Probable disease resistance protein At1g59620"
FT /id="PRO_0000212744"
FT DOMAIN 123..432
FT /note="NB-ARC"
FT REPEAT 543..567
FT /note="LRR 1"
FT REPEAT 568..590
FT /note="LRR 2"
FT REPEAT 703..726
FT /note="LRR 3"
FT REPEAT 735..758
FT /note="LRR 4"
FT REPEAT 759..786
FT /note="LRR 5"
FT REPEAT 808..833
FT /note="LRR 6"
FT BINDING 167..174
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 462..496
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10548732"
FT /id="VSP_042239"
FT VAR_SEQ 725..730
FT /note="MPRLPD -> SFLMSF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10548732"
FT /id="VSP_042240"
FT VAR_SEQ 731..870
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10548732"
FT /id="VSP_042241"
SQ SEQUENCE 870 AA; 101033 MW; DC93C2B61357A6D7 CRC64;
MAETLLSFGV EKLWDLLVRE SDRFQGVKKQ FNELRSDLNK LRCFLEDADA KKHQSAMVSN
TVKEVKEIVY DTEDIIETFL RKKQLGRTRG MKKRIKEFAC VLPDRRKIAI DMEGLSKRIA
KKDKRNMRQT FSNNNESVLV GLEENVKKLV GHLVEVEDSS QVVSITGMGG IGKTTLARQV
FNHETVKSHF AQLAWVCVSQ QFTRKYVWQT ILRKVGPEYI KLEMTEDELQ EKLFRLLGTR
KALIVLDDIW REEDWDMIEP IFPLGKGWKV LLTSRNEGVA LRANPNGFIF KPDCLTPEES
WTIFRRIVFP GENTTEYKVD EKMEELGKQM IKHCGGLPLA LKVLGGLLVV HFTLDEWKRI
YGNIKSHIVG GTSFNDKNMS SVYHILHLSF EELPIYLKHC FLYLAQFPED FTIDLEKLSY
YWAAEGMPRP RYYDGATIRK VGDGYIEELV KRNMVISERD ARTRRFETCH LHDIVREVCL
KAEEENLIET ENSKSPSKPR RLVVKGGDKT DMEGKLKNPK LRSLLFIEEL GGYRGFEVWF
TRLQLMRVLD LHGVEFGGEL PSSIGLLIHL RYLSLYRAKA SHLPSSMQNL KMLLYLNLCV
QESCYIYIPN FLKEMLELKY LSLPLRMDDK VKLELGNLVN LEKLENFSTE HGGVGDLQFM
TRLRALSIYI RGRLNMKTLS SSLSKLRDLE NLTICYYPMY APMSGIEGLV LDCDQLKHLN
LRIYMPRLPD EQHFPWHLRN ISLAECCLKE DPMPILEKLL QLNEVSLSHQ SFCGKRMVCS
DGGFPQLQKL DLCGLEEWEE WIVEEGSMPR LHKLTIRNDP KLKELPDGLK FITSLKEVHV
ILNNWDFKKK LSRGGEDYYK VQHIPLVRFL
