DRL13_ARATH
ID DRL13_ARATH Reviewed; 906 AA.
AC Q9XIF0;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Putative disease resistance protein At1g59780;
GN OrderedLocusNames=At1g59780; ORFNames=F23H11.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Potential disease resistance protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AC007258; AAD39321.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33617.1; -; Genomic_DNA.
DR PIR; G96621; G96621.
DR RefSeq; NP_176187.1; NM_104671.1.
DR AlphaFoldDB; Q9XIF0; -.
DR SMR; Q9XIF0; -.
DR BioGRID; 27496; 3.
DR STRING; 3702.AT1G59780.1; -.
DR PaxDb; Q9XIF0; -.
DR PRIDE; Q9XIF0; -.
DR ProteomicsDB; 224310; -.
DR EnsemblPlants; AT1G59780.1; AT1G59780.1; AT1G59780.
DR GeneID; 842271; -.
DR Gramene; AT1G59780.1; AT1G59780.1; AT1G59780.
DR KEGG; ath:AT1G59780; -.
DR Araport; AT1G59780; -.
DR TAIR; locus:2025916; AT1G59780.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_4_1; -.
DR InParanoid; Q9XIF0; -.
DR OrthoDB; 164862at2759; -.
DR PhylomeDB; Q9XIF0; -.
DR PRO; PR:Q9XIF0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XIF0; baseline and differential.
DR Genevisible; Q9XIF0; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..906
FT /note="Putative disease resistance protein At1g59780"
FT /id="PRO_0000212745"
FT DOMAIN 138..452
FT /note="NB-ARC"
FT REPEAT 572..597
FT /note="LRR 1"
FT REPEAT 599..619
FT /note="LRR 2"
FT REPEAT 620..644
FT /note="LRR 3"
FT REPEAT 825..850
FT /note="LRR 4"
FT COILED 20..59
FT /evidence="ECO:0000255"
FT BINDING 187..194
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 906 AA; 103630 MW; 6A47A918EF1A45FB CRC64;
MQDLYMVDSI VSFGVEKLWK LLSQEYERFQ GVEEQITELR DDLKMLMAFL SDADAKKQTR
ALARNCLEEI KEITYDAEDI IEIFLLKGSV NMRSLACFPG GRREIALQIT SISKRISKVI
QVMQNLGIKS DIMDGVDSHA QLERKRELRH TFSSESESNL VGLEKNVEKL VEELVGNDSS
HGVSITGLGG LGKTTLARQI FDHDKVKSHF DGLAWVCVSQ EFTRKDVWKT ILGNLSPKYK
DSDLPEDDIQ KKLFQLLETK KALIVFDDLW KREDWYRIAP MFPERKAGWK VLLTSRNDAI
HPHCVTFKPE LLTHDECWKL LQRIAFSKQK TITGYIIDKE MVKMAKEMTK HCKRLPLAVK
LLGGLLDAKH TLRQWKLISE NIISHIVVGG TSSNENDSSS VNHVLSLSFE GLPGYLKHCL
LYLASYPEDH EIEIERLSYV WAAEGITYPG NYEGATIRDV ADLYIEELVK RNMVISERDA
LTSRFEKCQL HDLMREICLL KAKEENFLQI VTDPTSSSSV HSLASSRSRR LVVYNTSIFS
GENDMKNSKL RSLLFIPVGY SRFSMGSNFI ELPLLRVLDL DGAKFKGGKL PSSIGKLIHL
KYLSLYQASV TYLPSSLRNL KSLLYLNLRI NSGQLINVPN VFKEMLELRY LSLPWERSSL
TKLELGNLLK LETLINFSTK DSSVTDLHRM TKLRTLQILI SGEGLHMETL SSALSMLGHL
EDLTVTPSEN SVQFKHPKLI YRPMLPDVQH FPSHLTTISL VYCFLEEDPM PTLEKLLQLK
VVSLWYNAYV GRRMVCTGGG FPPLHRLEIW GLDALEEWIV EEGSMPLLHT LHIVDCKKLK
EIPDGLRFIS SLKELAIRTN EKVFQKKVSK GGEDYYKMQH VPLIRYNWPQ EPENNEVIYS
FPSPII
