ID   DRL14_ARATH             Reviewed;         893 AA.
AC   Q9SI85; O82099; Q9SXD4;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Probable disease resistance protein At1g62630;
DE   AltName: Full=pNd4;
GN   OrderedLocusNames=At1g62630; ORFNames=F23N19.1, T3P18.19;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 181-351.
RC   STRAIN=cv. Nd-1;
RX   PubMed=9670562; DOI=10.1046/j.1365-313x.1998.00138.x;
RA   Speulman E., Bouchez D., Holub E.B., Beynon J.L.;
RT   "Disease resistance gene homologs correlate with disease resistance loci of
RT   Arabidopsis thaliana.";
RL   Plant J. 14:467-474(1998).
CC   -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF19533.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AC005698; AAD43620.1; -; Genomic_DNA.
DR   EMBL; AC007190; AAF19533.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE33988.1; -; Genomic_DNA.
DR   EMBL; U97220; AAC50028.1; -; Genomic_DNA.
DR   PIR; H96651; H96651.
DR   RefSeq; NP_176451.1; NM_104941.2.
DR   AlphaFoldDB; Q9SI85; -.
DR   SMR; Q9SI85; -.
DR   STRING; 3702.AT1G62630.1; -.
DR   iPTMnet; Q9SI85; -.
DR   PaxDb; Q9SI85; -.
DR   PRIDE; Q9SI85; -.
DR   ProteomicsDB; 224311; -.
DR   EnsemblPlants; AT1G62630.1; AT1G62630.1; AT1G62630.
DR   GeneID; 842560; -.
DR   Gramene; AT1G62630.1; AT1G62630.1; AT1G62630.
DR   KEGG; ath:AT1G62630; -.
DR   Araport; AT1G62630; -.
DR   TAIR; locus:2203881; AT1G62630.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000427_4_0_1; -.
DR   InParanoid; Q9SI85; -.
DR   OMA; MGTICLE; -.
DR   OrthoDB; 320361at2759; -.
DR   PhylomeDB; Q9SI85; -.
DR   PRO; PR:Q9SI85; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9SI85; baseline and differential.
DR   Genevisible; Q9SI85; AT.
DR   GO; GO:0005634; C:nucleus; HDA:TAIR.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..893
FT                   /note="Probable disease resistance protein At1g62630"
FT                   /id="PRO_0000212746"
FT   DOMAIN          136..440
FT                   /note="NB-ARC"
FT   REPEAT          516..537
FT                   /note="LRR 1"
FT   REPEAT          538..559
FT                   /note="LRR 2"
FT   REPEAT          571..593
FT                   /note="LRR 3"
FT   REPEAT          595..617
FT                   /note="LRR 4"
FT   REPEAT          618..640
FT                   /note="LRR 5"
FT   REPEAT          641..663
FT                   /note="LRR 6"
FT   COILED          24..68
FT                   /evidence="ECO:0000255"
FT   BINDING         179..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        208
FT                   /note="W -> R (in Ref. 3; AAC50028)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        336
FT                   /note="L -> I (in Ref. 3; AAC50028)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        347
FT                   /note="L -> F (in Ref. 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        500
FT                   /note="R -> C (in Ref. 1; AAF19533)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   893 AA;  101905 MW;  E506E93F155368DC CRC64;
     MGISFSIPFD PCVNKVSQWL DMKGSYTHNL EKNLVALETT MEELKAKRDD LLRRLKREED
     RGLQRLSEFQ VWLNRVATVE DIIITLLRDR DVEIQRLCLC RFCSKNLTTS YRYGKSVFLR
     LREVEKLKGE VFGVITEQAS TSAFEERPLQ PTIVGQKKML DKAWKHLMED GTGIMGMYGM
     GGVGKTTLLT QLFNMFNKDK CGFDIGIWVV VSQEVNVEKI QDEIAQKLGL GGHEWTQRDI
     SQKGVHLFNF LKNKKFVLFL DDLWDKVELA NIGVPDPRTQ KGCKLAFTSR SLNVCTSMGD
     EEPMEVQCLE ENVAFDLFQK KVGQKTLGSD PGIPQLARIV AKKCCGLPLA LNVIGETMSC
     KRTIQEWRNA IHVLNSYAAE FIGMEDKILP LLKYSYDNLK GEHVKSSLLY CALYPEDAKI
     RKEDLIEHWI CEEIIDGSEG IEKAEDKGYD IIGSLVRASL LMECVDLKGK SSVIMHDVVR
     EMALWIASEL GIQKEAFIVR AGVGVREIPK VKNWNVVRRM SLMGNKIHHL VGSYECMELT
     TLLLGEGEYG SIWRWSEIKT ISSEFFNCMP KLAVLDLSHN QSLFELPEEI SNLVSLKYLN
     LSHTGIRHLS KGIQELKKII HLNLEHTSKL ESIDGISSLH NLKVLKLYGS RLPWDLNTVK
     ELETLEHLEI LTTTIDPRAK QFLSSHRLMS RSRLLQIFGS NIFSPDRQLE SLSVSTDKLR
     EFEIMCCSIS EIKMGGICNF LSLVDVTIYN CEGLRELTFL IFAPKLRSLS VVDAKDLEDI
     INEEKACEGE DSGIVPFPEL KYLNLDDLPK LKNIYRRPLP FLCLEKITIG ECPNLRKLPL
     DSRSGKQGEN GCIIHYKDSR WLKGVKWADE ATKKRFLPSC EHRLERCETI FED