ID   DRL16_ARATH             Reviewed;         967 AA.
AC   O22727;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Probable disease resistance protein At1g61190;
GN   OrderedLocusNames=At1g61190; ORFNames=F11P17.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AC002294; AAB71476.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE33801.1; -; Genomic_DNA.
DR   PIR; G96637; G96637.
DR   RefSeq; NP_176314.1; NM_104800.1.
DR   AlphaFoldDB; O22727; -.
DR   SMR; O22727; -.
DR   STRING; 3702.AT1G61190.1; -.
DR   PaxDb; O22727; -.
DR   PRIDE; O22727; -.
DR   ProteomicsDB; 224313; -.
DR   EnsemblPlants; AT1G61190.1; AT1G61190.1; AT1G61190.
DR   GeneID; 842412; -.
DR   Gramene; AT1G61190.1; AT1G61190.1; AT1G61190.
DR   KEGG; ath:AT1G61190; -.
DR   Araport; AT1G61190; -.
DR   TAIR; locus:2008510; AT1G61190.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000427_4_0_1; -.
DR   InParanoid; O22727; -.
DR   OrthoDB; 236715at2759; -.
DR   PhylomeDB; O22727; -.
DR   PRO; PR:O22727; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; O22727; baseline and differential.
DR   Genevisible; O22727; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..967
FT                   /note="Probable disease resistance protein At1g61190"
FT                   /id="PRO_0000212748"
FT   DOMAIN          138..441
FT                   /note="NB-ARC"
FT   REPEAT          516..537
FT                   /note="LRR 1"
FT   REPEAT          538..559
FT                   /note="LRR 2"
FT   REPEAT          562..585
FT                   /note="LRR 3"
FT   REPEAT          586..608
FT                   /note="LRR 4"
FT   REPEAT          609..631
FT                   /note="LRR 5"
FT   REGION          132..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          20..68
FT                   /evidence="ECO:0000255"
FT   BINDING         180..187
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   967 AA;  111532 MW;  9037FAA7BFEC7827 CRC64;
     MGNFVCIEIS GDQMLDRIIR CLCGKGYIRN LEKNLRALQR EMEDLRATQH EVQNKVAREE
     SRHQQRLEAV QVWLDRVNSI DIECKDLLSV SPVELQKLCL CGLCSKYVCS SYKYGKRVFL
     LLEEVTKLKS EGNFDEVSQP PPRSEVEERP TQPTIGQEEM LKKAWNRLME DGVGIMGLHG
     MGGVGKTTLF KKIHNKFAET GGTFDIVIWI VVSQGAKLSK LQEDIAEKLH LCDDLWKNKN
     ESDKATDIHR VLKGKRFVLM LDDIWEKVDL EAIGIPYPSE VNKCKVAFTT RDQKVCGQMG
     DHKPMQVKCL EPEDAWELFK NKVGDNTLRS DPVIVGLARE VAQKCRGLPL ALSCIGETMA
     SKTMVQEWEH AIDVLTRSAA EFSDMQNKIL PILKYSYDSL EDEHIKSCFL YCALFPEDDK
     IDTKTLINKW ICEGFIGEDQ VIKRARNKGY EMLGTLIRAN LLTNDRGFVK WHVVMHDVVR
     EMALWIASDF GKQKENYVVR ARVGLHEIPK VKDWGAVRRM SLMMNEIEEI TCESKCSELT
     TLFLQSNQLK NLSGEFIRYM QKLVVLDLSH NPDFNELPEQ ISGLVSLQYL DLSWTRIEQL
     PVGLKELKKL IFLNLCFTER LCSISGISRL LSLRWLSLRE SNVHGDASVL KELQQLENLQ
     DLRITESAEL ISLDQRLAKL ISVLRIEGFL QKPFDLSFLA SMENLYGLLV ENSYFSEINI
     KCRESETESS YLHINPKIPC FTNLTGLIIM KCHSMKDLTW ILFAPNLVNL DIRDSREVGE
     IINKEKAINL TSIITPFQKL ERLFLYGLPK LESIYWSPLP FPLLSNIVVK YCPKLRKLPL
     NATSVPLVEE FEIRMDPPEQ ENELEWEDED TKNRFLPSIK PLVRRLKIHY SGMGFLNVKN
     QNPRFFFYCF IYLLVVHLDC IIDLHSDTSG MCCVVHLDYV FHFPFVFPKT FCILFRLHFY
     TIKSLCV