DRL17_ARATH
ID DRL17_ARATH Reviewed; 762 AA.
AC O64790; Q8L4D2;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable disease resistance protein At1g61300;
GN OrderedLocusNames=At1g61300; ORFNames=T1F9.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-704.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC13911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM20459.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=AAM91258.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AC004255; AAC13911.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33818.1; -; Genomic_DNA.
DR EMBL; AK226587; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY099608; AAM20459.1; ALT_SEQ; mRNA.
DR EMBL; AY128858; AAM91258.1; ALT_SEQ; mRNA.
DR RefSeq; NP_176325.2; NM_104811.4.
DR AlphaFoldDB; O64790; -.
DR SMR; O64790; -.
DR STRING; 3702.AT1G61300.1; -.
DR PaxDb; O64790; -.
DR PRIDE; O64790; -.
DR ProteomicsDB; 224314; -.
DR EnsemblPlants; AT1G61300.1; AT1G61300.1; AT1G61300.
DR GeneID; 842424; -.
DR Gramene; AT1G61300.1; AT1G61300.1; AT1G61300.
DR KEGG; ath:AT1G61300; -.
DR Araport; AT1G61300; -.
DR TAIR; locus:2197739; AT1G61300.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_4_0_1; -.
DR InParanoid; O64790; -.
DR OMA; SHTHIVR; -.
DR OrthoDB; 169620at2759; -.
DR PhylomeDB; O64790; -.
DR PRO; PR:O64790; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O64790; baseline and differential.
DR Genevisible; O64790; AT.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell membrane; Leucine-rich repeat; Lipoprotein; Membrane;
KW Myristate; Nucleotide-binding; Palmitate; Plant defense;
KW Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..762
FT /note="Probable disease resistance protein At1g61300"
FT /id="PRO_0000212749"
FT DOMAIN 26..329
FT /note="NB-ARC"
FT REPEAT 401..422
FT /note="LRR 1"
FT REPEAT 423..444
FT /note="LRR 2"
FT REPEAT 447..470
FT /note="LRR 3"
FT REPEAT 471..493
FT /note="LRR 4"
FT REPEAT 494..516
FT /note="LRR 5"
FT BINDING 68..75
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT LIPID 3
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 4
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 762 AA; 87132 MW; 601993112A3BFF91 CRC64;
MGCCFSVQFS FDDQTLVRIF NFLCGNINRN SFGVEERPTQ PTIGQEEMLE KAWNRLMEDR
VGIMGLHGMG GVGKTTLFKK IHNKFAKMSS RFDIVIWIVV SKGAKLSKLQ EDIAEKLHLC
DDLWKNKNES DKATDIHRVL KGKRFVLMLD DIWEKVDLEA IGVPYPSEVN KCKVAFTTRD
QKVCGEMGDH KPMQVKCLEP EDAWELFKNK VGDNTLRSDP VIVELAREVA QKCRGLPLAL
SVIGETMASK TMVQEWEHAI DVLTRSAAEF SNMGNKILPI LKYSYDSLGD EHIKSCFLYC
ALFPEDDEIY NEKLIDYWIC EGFIGEDQVI KRARNKGYEM LGTLTLANLL TKVGTEHVVM
HDVVREMALW IASDFGKQKE NFVVRARVGL HERPEAKDWG AVRRMSLMDN HIEEITCESK
CSELTTLFLQ SNQLKNLSGE FIRYMQKLVV LDLSYNRDFN KLPEQISGLV SLQFLDLSNT
SIKQLPVGLK KLKKLTFLNL AYTVRLCSIS GISRLLSLRL LRLLGSKVHG DASVLKELQK
LQNLQHLAIT LSAELSLNQR LANLISILGI EGFLQKPFDL SFLASMENLS SLWVKNSYFS
EIKCRESETA SSYLRINPKI PCFTNLSRLG LSKCHSIKDL TWILFAPNLV YLYIEDSREV
GEIINKEKAT NLTSITPFLK LERLILYNLP KLESIYWSPL HFPRLLIIHV LDCPKLRKLP
LNATSVPLVE EFQIRMYPPG LGNELEWEDE DTKNRFVLSI KK
