ID   DRL18_ARATH             Reviewed;         925 AA.
AC   O64789; F4HTJ4;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Probable disease resistance protein At1g61310;
GN   OrderedLocusNames=At1g61310; ORFNames=T1F9.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AC004255; AAC13910.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE33819.1; -; Genomic_DNA.
DR   PIR; H96638; H96638.
DR   RefSeq; NP_176326.2; NM_104812.3.
DR   AlphaFoldDB; O64789; -.
DR   SMR; O64789; -.
DR   BioGRID; 27648; 2.
DR   STRING; 3702.AT1G61310.1; -.
DR   PaxDb; O64789; -.
DR   PRIDE; O64789; -.
DR   GeneID; 842425; -.
DR   KEGG; ath:AT1G61310; -.
DR   Araport; AT1G61310; -.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000427_4_0_1; -.
DR   InParanoid; O64789; -.
DR   OrthoDB; 236715at2759; -.
DR   PhylomeDB; O64789; -.
DR   PRO; PR:O64789; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; O64789; baseline and differential.
DR   Genevisible; O64789; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..925
FT                   /note="Probable disease resistance protein At1g61310"
FT                   /id="PRO_0000212750"
FT   DOMAIN          139..442
FT                   /note="NB-ARC"
FT   REPEAT          525..546
FT                   /note="LRR 1"
FT   REPEAT          547..568
FT                   /note="LRR 2"
FT   REPEAT          571..594
FT                   /note="LRR 3"
FT   REPEAT          595..617
FT                   /note="LRR 4"
FT   REPEAT          618..640
FT                   /note="LRR 5"
FT   REPEAT          641..663
FT                   /note="LRR 6"
FT   REGION          134..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..69
FT                   /evidence="ECO:0000255"
FT   BINDING         181..188
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        34
FT                   /note="K -> Q (in Ref. 2; AEE33819)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   925 AA;  105062 MW;  96F4FDBDEEBB33C4 CRC64;
     MGSCFSFQIA VGDQTMNRIF DCLIGKSYIR TLEKNLRALQ REMEDLRATQ HEVQNKVARE
     ESRHQQRLEA VQVWLDRVNS IDIECKDLLS VSPVELQKLC LCGLCTKYVC SSYKYGKKVF
     LLLEEVKILK SEGNFDEVSQ PPPRSEVEER PTQPTIGQEE MLEKAWNRLM EDGVGIMGLH
     GMGGVGKTTL FKKIHNKFAE IGGTFDIVIW IVVSQGAKLS KLQEDIAEKL HLCDDLWKNK
     NESDKATDIH RVLKGKRFVL MLDDIWEKVD LEAIGIPYPS EVNKCKVAFT TRSREVCGEM
     GDHKPMQVNC LEPEDAWELF KNKVGDNTLS SDPVIVGLAR EVAQKCRGLP LALNVIGETM
     ASKTMVQEWE YAIDVLTRSA AEFSGMENKI LPILKYSYDS LGDEHIKSCF LYCALFPEDG
     QIYTETLIDK LICEGFIGED QVIKRARNKG YAMLGTLTRA NLLTKVGTEL ANLLTKVSIY
     HCVMHDVVRE MALWIASDFG KQKENFVVQA SAGLHEIPEV KDWGAVRRMS LMRNEIEEIT
     CESKCSELTT LFLQSNQLKN LSGEFIRYMQ KLVVLDLSDN RDFNELPEQI SGLVSLQYLD
     LSFTRIEQLP VGLKELKKLT FLDLAYTARL CSISGISRLL SLRVLSLLGS KVHGDASVLK
     ELQQLENLQD LAITLSAELI SLDQRLAKVI SILGIEGFLQ KPFDLSFLAS MENLSSLWVK
     NSYFSEIKCR ESETDSSYLH INPKIPCFTN LSRLDIVKCH SMKDLTWILF APNLVVLFIE
     DSREVGEIIN KEKATNLTSI TPFLKLERLI LCYLPKLESI YWSPLPFPLL LNIDVEECPK
     LRKLPLNATS APKVEEFRIL MYPPELEWED EDTKNRFLPE MVSTSTSSKD PLLRNGIPRC
     LKSESTLLLL ILLYLSSCRA FGLYN